{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"以2-氯苯甲醛与2,4-<span style=\"color:red\">二</span>氯苯乙酮缩合形成α,β不饱和酮,然后和水合肼关环形成3-(2,4-<span style=\"color:red\">二</span>氯苯基)-5-(2-氯苯基)<span style=\"color:red\">吡唑</span>结构骨架,合成了8个未见文献报道的3-(2,4-<span style=\"color:red\">二</span>氯苯基)-5-(2-氯苯基)-4,5<span style=\"color:red\">二</span>氢-N-酰<span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>类衍生物.经过元素分析、红外光谱、核磁共振氢谱测试技术对其结构进行了表征.对新合成的化合物进行了初步生物活性测试结果表明,在化合物的质量浓度为50 mg/L时,化合物3f对水稻纹枯菌和稻瘟病菌的抑菌率分别为55.2%和57.1%.化合物3g对水稻纹枯菌、稻瘟病菌和油菜菌核菌的抑菌率分别为52.3%、60.0%和50.4%.","authors":[{"authorName":"刘新华","id":"2872c8ad-ec47-4771-9fed-32a565299033","originalAuthorName":"刘新华"},{"authorName":"宋宝安","id":"3cc86873-0af9-491b-bbf4-e063778d1f4b","originalAuthorName":"宋宝安"},{"authorName":"李波","id":"5f5855e5-71fb-4781-bb6c-31a7137bc05d","originalAuthorName":"李波"}],"doi":"10.3969/j.issn.1000-0518.2007.07.023","fpage":"835","id":"c23dbae0-f41c-43ae-b228-74f2524a7643","issue":"7","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"e66ad2db-7fdd-40d2-9cdf-764545b49692","keyword":"氯苯甲醛","originalKeyword":"氯苯甲醛"},{"id":"a9409321-d8d0-4a98-8d8b-fc5f4aad4960","keyword":"<span style=\"color:red\">二</span><span style=\"color:red\">芳</span><span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>","originalKeyword":"二芳基吡唑"},{"id":"7730a8b2-c98c-47b8-9cfa-053b675d4351","keyword":"合成","originalKeyword":"合成"},{"id":"a5428785-111c-43ea-bc07-285569bfe06a","keyword":"杀菌活性","originalKeyword":"杀菌活性"}],"language":"zh","publisherId":"yyhx200707023","title":"新型3,5-<span style=\"color:red\">二</span><span style=\"color:red\">芳</span><span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>衍生物的合成与抑菌活性","volume":"24","year":"2007"},{"abstractinfo":"以2-甲基-6-苯基-3-(2,4-<span style=\"color:red\">二</span>氯苯基)-5,7-<span style=\"color:red\">二</span>羟基<span style=\"color:red\">吡唑</span>并[1,5-a]嘧啶为原料,经三氯氧磷氯代得到2-甲基-6-苯基-3-(2,4-<span style=\"color:red\">二</span>氯苯基)-5,7-<span style=\"color:red\">二</span>氯<span style=\"color:red\">吡唑</span>并[1,5-a]嘧啶,氯代物再与胺类化合物经取代反应氨化得到12个未见文献报道的7-取代-3,6-<span style=\"color:red\">二</span><span style=\"color:red\">芳</span><span style=\"color:red\">基</span>取代<span style=\"color:red\">吡唑</span>并[1,5-a]嘧啶类衍生物.目标化合物结构经红外光谱、核磁共振氢谱、元素分析及单晶X射线衍射法表征.","authors":[{"authorName":"刘举","id":"048d0ee4-ad3a-4ac8-9da5-98694f642607","originalAuthorName":"刘举"},{"authorName":"敬春艳","id":"47df4e34-d4a5-46ff-aad2-036a9a94a3f3","originalAuthorName":"敬春艳"},{"authorName":"王洋","id":"42524d52-898e-4e94-a593-1840967a4648","originalAuthorName":"王洋"},{"authorName":"滕鹏飞","id":"2358519b-c02b-449c-b3b3-2c2803e5739b","originalAuthorName":"滕鹏飞"},{"authorName":"徐嘉瞳","id":"5ab0b371-2080-455b-af59-8723fca4159f","originalAuthorName":"徐嘉瞳"},{"authorName":"徐利锋","id":"5a24f270-b2ec-40c9-a63b-a35e127b4fde","originalAuthorName":"徐利锋"}],"doi":"10.3724/SP.J.1095.2013.20574","fpage":"1494","id":"2dc32c72-ffad-4c40-a852-4fd7575724d9","issue":"12","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"d0f9c97a-9d11-40fc-94bd-bd3617f3c66d","keyword":"<span style=\"color:red\">吡唑</span>并[1,5-a]嘧啶","originalKeyword":"吡唑并[1,5-a]嘧啶"},{"id":"dc9c4d99-430d-4601-b995-cad24410ffdb","keyword":"氯代反应","originalKeyword":"氯代反应"},{"id":"561cab1e-c426-4fd8-b6c0-c5385a0773f2","keyword":"氨化反应","originalKeyword":"氨化反应"},{"id":"caa2bbd1-3bfb-4738-8383-550605bcc5ad","keyword":"晶体结构","originalKeyword":"晶体结构"}],"language":"zh","publisherId":"yyhx201312020","title":"新型3,6-<span style=\"color:red\">二</span><span style=\"color:red\">芳</span><span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>并[1,5-a]嘧啶类化合物的合成","volume":"30","year":"2013"},{"abstractinfo":"以苯肼和乙酰乙酸乙酯为基本原料,经关环、甲酰<span style=\"color:red\">基</span>化、氧化和酰氯化反应得到酰氯,所得中间体4在相转移催化剂(PEG-600)存在下与硫氰酸铵反应得到相应的<span style=\"color:red\">吡唑</span>甲酰异硫氰酸酯,再分别与含氟苯胺反应,得到9个未见报道的<span style=\"color:red\">吡唑</span>甲酰<span style=\"color:red\">基</span>含氟<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>硫脲衍生物.经IR、1H NMR和元素分析测试技术确认了化合物的结构.对新合成的化合物进行了初步的抑菌活性测试,结果表明,化合物6a、6b、6d、6e、6f、6g、6h和6i在质量浓度为1-100 mg/L范围内,对水稻纹枯病菌抑制率均为100％,化合物6e在50 ms/L时,对小麦赤霉病菌抑制率达98.2％.","authors":[{"authorName":"张袖丽","id":"03770f77-e3b3-491b-8e8a-2bbf4ad84860","originalAuthorName":"张袖丽"},{"authorName":"吕献海","id":"f2ba35be-9b0c-404a-80d2-a524fc08f36b","originalAuthorName":"吕献海"},{"authorName":"江万权","id":"becc811b-b547-4be3-8933-5784746e9e51","originalAuthorName":"江万权"}],"doi":"10.3969/j.issn.1000-0518.2008.04.018","fpage":"459","id":"283f7cd3-6cc4-4f10-b1d6-0cc17566c9e5","issue":"4","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"37b82f9a-c32a-4d76-927e-fda408f4b989","keyword":"<span style=\"color:red\">吡唑</span>","originalKeyword":"吡唑"},{"id":"64327409-3093-4f40-9f24-e7a9d22274df","keyword":"酰<span style=\"color:red\">基</span>硫脲","originalKeyword":"酰基硫脲"},{"id":"4c6f6f16-56e3-42e9-967f-35b2d25e04d7","keyword":"含氟苯胺","originalKeyword":"含氟苯胺"},{"id":"c177c287-5f0f-4588-a8e0-696f1985b902","keyword":"合成","originalKeyword":"合成"},{"id":"bc0b24b6-31c9-452f-bb18-56b9c00241f7","keyword":"杀菌活性","originalKeyword":"杀菌活性"}],"language":"zh","publisherId":"yyhx200804018","title":"新型<span style=\"color:red\">吡唑</span>甲酰<span style=\"color:red\">基</span>含氟<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>硫脲的合成及其杀菌活性","volume":"25","year":"2008"},{"abstractinfo":"以2-氨基-5-取代-l,3,4-噻<span style=\"color:red\">二</span>唑为起始原料,设计合成16个含l,3,4-噻<span style=\"color:red\">二</span>唑取代<span style=\"color:red\">基</span>的中间体4a～4p,进而使其在POCl3及DMF作用下反应得到16个3-取代-1-(5-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>-1,3,4-噻<span style=\"color:red\">二</span>唑-2-<span style=\"color:red\">基</span>)-1H-<span style=\"color:red\">吡唑</span>-4-甲醛化合物5a～5p,所合成的32个化合物均为新化合物.采用溶液结晶法获得化合物5a晶体,通过X射线单晶衍射测得该晶体属于三斜晶系,P-1空间群.借助IR、1H NMR、元素分析等技术手段对合成的所有化合物结构进行了表征.利用微量稀释法测试了化合物5a ～5p的抑菌活性,结果表明,部分化合物对金黄色葡萄球菌具有抑制作用,在相同条件下化合物5h的抑菌活性最好,抑菌率达到65.30％.","authors":[{"authorName":"徐畅","id":"238a801d-feb7-4a09-b493-60aa8e162de4","originalAuthorName":"徐畅"},{"authorName":"安悦","id":"f35902cd-6b88-4fa3-9145-20c23e4aa35d","originalAuthorName":"安悦"},{"authorName":"朱浩天","id":"249cecf6-c0df-48ed-9a78-73f7938ae79b","originalAuthorName":"朱浩天"},{"authorName":"林越","id":"df3df5d3-3093-49d2-be31-20d60dc8991e","originalAuthorName":"林越"},{"authorName":"王日楠","id":"9c05ad9b-bda6-4200-b4ad-0f11948b0195","originalAuthorName":"王日楠"}],"doi":"10.11944/j.issn.1000-0518.2015.07.140421","fpage":"748","id":"576cdacc-be0a-4f9b-a96f-0752c6db8904","issue":"7","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"814c48ff-46bc-4d87-923c-bcac86612c54","keyword":"噻<span style=\"color:red\">二</span>唑","originalKeyword":"噻二唑"},{"id":"486d3090-f94b-46f4-b253-495c95246b34","keyword":"<span style=\"color:red\">吡唑</span>","originalKeyword":"吡唑"},{"id":"9f78828e-c004-45ff-a83b-3d443b38cec8","keyword":"合成","originalKeyword":"合成"},{"id":"7a236987-cece-42c2-9b7a-76f382dc4800","keyword":"有机单晶","originalKeyword":"有机单晶"},{"id":"6f9a2198-b637-4402-9813-15a1a1694e4d","keyword":"生物活性","originalKeyword":"生物活性"}],"language":"zh","publisherId":"yyhx201507003","title":"3-取代-1-(5-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>-1,3,4-噻<span style=\"color:red\">二</span>唑-2-<span style=\"color:red\">基</span>)-1H-<span style=\"color:red\">吡唑</span>-4-甲醛的合成、晶体结构及抑菌活性","volume":"32","year":"2015"},{"abstractinfo":"以2-氯苯甲醛与酮缩合形成α,β不饱和酮,与水合肼关环形成5-(2-氯苯基)<span style=\"color:red\">吡唑</span>结构骨架,合成了18种未见文献报道的5-(2-氯苯基)-3-甲基(或乙基)-4,5-<span style=\"color:red\">二</span>氢-N-酰<span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>类衍生物,并经过元素分析、红外光谱、核磁共振氢谱测试技术对其结构进行了表征. 对新合成的化合物进行了初步生物活性测试. 结果表明,化合物3ae对稻瘟病菌的抑菌率达到60.2%,化合物3bf对油菜菌核菌的抑菌率达到56.7%. 化合物3aj和3bj对供试病菌均有50%左右的抑菌率.","authors":[{"authorName":"刘新华","id":"cee0b8c9-c67b-418e-b3a4-146a21a23cf3","originalAuthorName":"刘新华"},{"authorName":"朱静","id":"1e2199ae-adf2-450b-84bc-3cb4cca3e172","originalAuthorName":"朱静"},{"authorName":"潘春秀","id":"0de083ba-57c7-453e-9e8e-f1a3599a956f","originalAuthorName":"潘春秀"},{"authorName":"宋宝安","id":"e604e173-1010-41c5-b11f-74e0c12d98d8","originalAuthorName":"宋宝安"}],"doi":"10.3969/j.issn.1000-0518.2007.10.015","fpage":"1162","id":"ac19199b-f8af-41ae-afcc-961d4a2efe0b","issue":"10","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"cad2a6ff-e353-40a8-89e5-1ab7c6474ec7","keyword":"<span style=\"color:red\">芳</span><span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>","originalKeyword":"芳基吡唑"},{"id":"a01da0ff-f3f7-429e-9371-6069de91d437","keyword":"合成","originalKeyword":"合成"},{"id":"670edc70-888c-436f-a506-24cc9070a5f4","keyword":"杀菌活性","originalKeyword":"杀菌活性"}],"language":"zh","publisherId":"yyhx200710015","title":"新型5-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>衍生物的合成与抑菌活性","volume":"24","year":"2007"},{"abstractinfo":"<span style=\"color:red\">吡唑</span>是含有两个相邻氮原子的五元杂环化合物,因其广泛而优良的生物活性而备受化学家关注。在过去几十年中,药物学和农药学领域对<span style=\"color:red\">吡唑</span>类衍生物进行了广泛研究。据文献报道,<span style=\"color:red\">吡唑</span>类衍生物具有镇痛、杀菌、消炎、抗抑郁、抗病毒、抗癌、减肥、降脂、降压和降糖等生物活性。不仅如此,<span style=\"color:red\">吡唑</span>化合物在有机化学中也非常有用,作为合成构件,在配位化学中被用作多功能配体,也在过渡金属交叉偶联反应和聚合反应中有所应用。近几年研究发现,<span style=\"color:red\">吡唑</span>类衍生物还可应用于紫外线稳定剂、含能材料和智能材料等领域。因此,探索简便高效的方法合成<span style=\"color:red\">吡唑</span>类化合物成为研究热点。目前合成<span style=\"color:red\">吡唑</span>环的方法很多,但多存在溶剂不环保、催化剂毒性大费用高、反应条件苛刻及产率低等缺点。<br>　　酞菁是一类具有18电子共轭<span style=\"color:red\">二</span>维平面芳香体系的大环化合物,与天然卟啉的结构极其相似。<span style=\"color:red\">二</span>者都易于利用光能进行光化学反应,环内有4个氮原子易与金属原子或离子配位形成金属配合物。研究表明,金属卟啉常作为氧化酶的活性位点而广泛存在于天然体系中,充当氧化还原反应的催化剂。因此,作为其类似物,金属酞菁被用作反应体系催化剂的研究成为热门。此外,金属酞菁具有高的热和化学稳定性,易于制备,无毒无味,可根据反应进行修饰改性等特点,非常适合用作催化剂。<br>　　考虑到金属酞菁在催化氧化反应上的良好效果,本文将其应用于催化α,β-不饱和酮与水合肼氧化<span style=\"color:red\">芳</span>构化反应。选用查尔酮与水合肼作为模板底物对反应条件进行优化。实验发现,使用氯化酞菁铁配合物作催化剂时,在碱存在下,室温下反应即可高效转化为3,5-<span style=\"color:red\">二</span>取代1H<span style=\"color:red\">吡唑</span>。在获得的最佳反应条件下拓展了底物范围,发现无论芳香环上的取代<span style=\"color:red\">基</span>是给电子基团还是吸电子基团,均能顺利地以较高收率得到相应<span style=\"color:red\">吡唑</span>衍生物。此外,由于氯化酞菁铁在乙醇中并不溶解,因此进行了催化剂回收套用实验。反应完成后,将催化剂过滤并用少量乙醇洗涤,然后以查尔酮与水合肼为反应模板进行催化剂循环实验,发现催化剂回收使用4次后,其催化活性并未降低。最后,对该反应机理进行了探究,在氮气气氛中得到并分离出了反应中间体。在确定了中间体结构后,将其在优化的反应条件下进行反应,也顺利得到了<span style=\"color:red\">吡唑</span>化合物。结合文献提出了可能的反应机理,即α,β-不饱和酮先与水合肼发生迈克尔加成,然后关环得到<span style=\"color:red\">吡唑</span>啉化合物,再经由氯化酞菁铁活化空气中氧分子氧化下,得到最终的3,5-<span style=\"color:red\">二</span>取代1H<span style=\"color:red\">吡唑</span>化合物。<br>　　总而言之,本文发展了一例氯化酞菁铁催化α,β-不饱和酮与水合肼的氧化<span style=\"color:red\">芳</span>构化反应,以较高收率实现了3,5-<span style=\"color:red\">二</span>取代<span style=\"color:red\">吡唑</span>化合物的合成。该方法具有反应条件温和、反应时间短、可循环使用5次、操作简易和利用空气作为氧化剂等优点。","authors":[{"authorName":"赵军龙","id":"a3e858f9-2221-4bcb-9408-caf9713c8e38","originalAuthorName":"赵军龙"},{"authorName":"邱骏","id":"a9f47771-bb43-4946-8518-5901cef44c49","originalAuthorName":"邱骏"},{"authorName":"苟小锋","id":"0763662a-6e3f-4a0a-96fe-f4cbacc05b95","originalAuthorName":"苟小锋"},{"authorName":"花成文","id":"6a8417fe-993f-4e90-9786-c861f56bb6c1","originalAuthorName":"花成文"},{"authorName":"陈邦","id":"a01d07cb-d147-4c82-9777-02a46fc3c67a","originalAuthorName":"陈邦"}],"doi":"10.1016/S1872-2067(15)61043-9|","fpage":"571","id":"685418fd-65e8-4552-9eac-4283ccb6d77d","issue":"4","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报   "},"keywords":[{"id":"4dd4204e-12be-4015-b336-988e7df68ec0","keyword":"氯化酞菁铁","originalKeyword":"氯化酞菁铁"},{"id":"43acf8ef-48ad-419a-ae58-40339912d73e","keyword":"<span style=\"color:red\">芳</span>构化","originalKeyword":"芳构化"},{"id":"477f4d5c-acc4-48b2-abb5-ac5e75b15b88","keyword":"<span style=\"color:red\">吡唑</span>","originalKeyword":"吡唑"},{"id":"8e4d824b-24a7-4446-b484-cdc3a573f43c","keyword":"迈克尔加成","originalKeyword":"迈克尔加成"},{"id":"73a9388e-9cef-4f6f-8df9-124de488de27","keyword":"可循环催化剂","originalKeyword":"可循环催化剂"},{"id":"cb7ce530-ce9b-471c-af9f-c4fcd9fa5f17","keyword":"绿色化学","originalKeyword":"绿色化学"}],"language":"zh","publisherId":"cuihuaxb201604014","title":"氯化酞菁铁（III）催化α,β-不饱和酮与水合肼氧化<span style=\"color:red\">芳</span>构化合成3,5-<span style=\"color:red\">二</span>取代1H<span style=\"color:red\">吡唑</span>","volume":"37","year":"2016"},{"abstractinfo":"用KMnO4/HOAc氧化2-甲硫<span style=\"color:red\">基</span>-5-<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>-1,3,4-(口恶)<span style=\"color:red\">二</span>唑1,得到中间体2-甲磺酰<span style=\"color:red\">基</span>-5-<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>-1,3,4-(口恶)<span style=\"color:red\">二</span>唑2,再通过<span style=\"color:red\">芳</span>胺的取代反应,得到目标化合物2-取代氨基-5-<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>-1,3,4-(口恶)<span style=\"color:red\">二</span>唑3. 2和3的结构经1H NMR和元素分析验证;从质谱的碎片峰解析了2A、2B 2个异构体的可能裂解途径. 对中间体及目标化合物的杀菌活性测试表明, 在质量分数为0.005%浓度下化合物2A及2B对芦笋茎枯菌的抑制率分别为40%和60% ,3A-5和3B-1也具有一定的杀菌活性.","authors":[{"authorName":"袁德凯","id":"34e2c276-28ed-4230-8523-2f04daf47277","originalAuthorName":"袁德凯"},{"authorName":"李正名","id":"4d875bf6-c856-43d1-a619-3e322b12f7a3","originalAuthorName":"李正名"},{"authorName":"赵卫光","id":"d6e2d34e-c1b6-41db-8b9a-be796aea014b","originalAuthorName":"赵卫光"},{"authorName":"陈寒松","id":"b2216933-680b-40fe-bd19-48e22f9821ae","originalAuthorName":"陈寒松"}],"doi":"10.3969/j.issn.1000-0518.2003.07.003","fpage":"624","id":"35146ea0-7f50-4b58-9df5-79bfeb41a86e","issue":"7","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"bf72a901-a50e-4208-8bc6-fc49f8bdf25c","keyword":"取代氨基<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>(口恶)<span style=\"color:red\">二</span>唑","originalKeyword":"取代氨基吡唑基(口恶)二唑"},{"id":"d4a5e323-2f9f-4c7f-a2c7-87e5348a4e4f","keyword":"合成","originalKeyword":"合成"},{"id":"79befdd9-348e-484e-8f74-13d105e0401a","keyword":"生物活性","originalKeyword":"生物活性"}],"language":"zh","publisherId":"yyhx200307003","title":"2-取代氨基-5-<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>-1,3,4-(口恶)<span style=\"color:red\">二</span>唑的合成及生物活性","volume":"20","year":"2003"},{"abstractinfo":"以水杨醛和丙酮缩合形成α,β不饱和酮,与水合肼和冰乙酸关环形成5-(2-羟基苯基)<span style=\"color:red\">吡唑</span>酮骨架,合成了10种未见报道的1-(5-(2-(苯氧基)苯基)-3-甲基)-4,5-<span style=\"color:red\">二</span>氢-N-<span style=\"color:red\">吡唑</span>肟酯类衍生物.通过元素分析、红外光谱及核磁共振氢谱测试技术对其结构进行了表征,初步测定了化合物的杀菌活性.结果表明,化合物对小麦赤霉病菌有较好的杀灭活性(其中化合物5f杀灭活性达到81.3%);化合物5g和5i对水稻纹枯病菌有中等杀灭活性,对稻瘟病菌的杀灭活性差.成了10种未见报道的1-(5-(2-(苯氧基)苯基)-3-甲基)-4,5-<span style=\"color:red\">二</span>氢-N-<span style=\"color:red\">吡唑</span>肟酯类衍生物.通过元素分析、红外光谱及核磁共振氢谱测试技术对其结构进行了表征,初步测定了化合物的杀菌活性.结果表明,化合物对小麦赤霉病菌有较好的杀灭活性(其中化合物5f杀灭活性达到81.3%);化合物5g和5i对水稻纹枯病菌有中等杀灭活性,对稻瘟病菌的杀灭活性差.","authors":[{"authorName":"崔平","id":"23d2e002-0d0b-4b07-a283-a8ff447baf8a","originalAuthorName":"崔平"},{"authorName":"刘新华","id":"52a03fde-b315-4237-9a59-e0e29146641c","originalAuthorName":"刘新华"},{"authorName":"智丽萍","id":"f897bd1f-1983-4464-b2b9-8a60b9b09ea8","originalAuthorName":"智丽萍"},{"authorName":"汪小虎","id":"88277dc1-14d9-4fb9-98e0-f52cd068b7ce","originalAuthorName":"汪小虎"},{"authorName":"宋宝安","id":"d47a93d0-f545-4b31-8e66-61ae084e6c8c","originalAuthorName":"宋宝安"},{"authorName":"左仁兵","id":"3ab2b568-dbe7-444c-b8e4-bbc4279c1614","originalAuthorName":"左仁兵"}],"doi":"10.3969/j.issn.1000-0518.2008.07.014","fpage":"820","id":"1bce825e-0697-4333-a301-bf5f9c6f6003","issue":"7","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"17295fa3-0eb5-469d-bdb0-736d6b34c9dd","keyword":"<span style=\"color:red\">吡唑</span>肟酯","originalKeyword":"吡唑肟酯"},{"id":"13d965ab-c4b7-45ab-893a-4b9c88a3546c","keyword":"合成","originalKeyword":"合成"},{"id":"2d445cf8-7aad-4920-81a8-2c36ea8f30e5","keyword":"杀菌活性","originalKeyword":"杀菌活性"}],"language":"zh","publisherId":"yyhx200807014","title":"新型5-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>-N-<span style=\"color:red\">吡唑</span>肟酯化合物的合成与杀菌活性","volume":"25","year":"2008"},{"abstractinfo":"在K2CO3-TEBA相转移催化体系中,4位或2位含有-NO2的苯磺酰<span style=\"color:red\">基</span>乙酸酯与α,β-不饱和酯发生加成-重排反应,制得2-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯,其收率较高(73%～87%).研究了反应物-<span style=\"color:red\">芳</span>磺酰<span style=\"color:red\">基</span>乙酸酯苯环上取代<span style=\"color:red\">基</span>对加成-重排反应的影响,发现只有当<span style=\"color:red\">芳</span>环上 4位或2位有硝基时,在K2CO3-TEBA相转移催化体系中,<span style=\"color:red\">芳</span>磺酰<span style=\"color:red\">基</span>乙酸酯与α,β-不饱和酯反应才可发生加成-重排反应,生成2-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯,其机理可能是<span style=\"color:red\">芳</span>磺酰<span style=\"color:red\">基</span>乙酸酯与α,β-不饱和酯首先发生Michael加成反应,随后加成产物发生分子内的亲核取代,酸化后脱去SO2得2-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯.而当<span style=\"color:red\">芳</span>环上4位或2位含有给电子基团(如,甲基)或弱吸电子基团(如,氯)时,却只能发生正常的Michael加成反应,生成相应的2-<span style=\"color:red\">芳</span>磺酰<span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯.","authors":[{"authorName":"陈文华","id":"c673c9d1-2b1a-4bc6-8095-2cad42f70711","originalAuthorName":"陈文华"},{"authorName":"张正","id":"114bdc3e-cb29-48ed-aaa4-abf288cc0fab","originalAuthorName":"张正"}],"doi":"10.3969/j.issn.1000-0518.2007.08.024","fpage":"961","id":"a8d8180f-5621-479d-8aa3-9231e570662e","issue":"8","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"ef63e040-d653-4e6c-aece-c7e3a60dec8d","keyword":"<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯","originalKeyword":"芳基戊二酸酯"},{"id":"820a9585-77a9-4ef2-8986-10274459108b","keyword":"<span style=\"color:red\">芳</span>磺酰<span style=\"color:red\">基</span>乙酸酯","originalKeyword":"芳磺酰基乙酸酯"},{"id":"b33c53d7-fa44-485e-af07-9ab929c800fb","keyword":"α","originalKeyword":"α"},{"id":"9e96347b-bec8-4e37-8f66-de35ebf4c0c2","keyword":"β-不饱和酯","originalKeyword":"β-不饱和酯"},{"id":"fdea2e67-6228-4c96-b100-f7f0778a6e80","keyword":"重排反应","originalKeyword":"重排反应"}],"language":"zh","publisherId":"yyhx200708024","title":"2-<span style=\"color:red\">芳</span><span style=\"color:red\">基</span>戊<span style=\"color:red\">二</span>酸酯的合成","volume":"24","year":"2007"},{"abstractinfo":"以FeCl_3·6H_2O为催化剂,无水乙醇为溶剂,n(取代-4-甲酰<span style=\"color:red\">基</span><span style=\"color:red\">吡唑</span>):n(乙酰乙酸乙酯):n((硫)脲):n(FeCl_3)·n(6H_2O)=1:3:3:1,采取微波辐射和常规加热回流的方法,通过Biginelli缩合反应一锅合成了6种新型含<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>的3,4-<span style=\"color:red\">二</span>氢嘧啶类化合物,并进行了元素分析、IR、~1H NMR和~(13)C NMR表征,对反应机理和化合物的图谱特征进行了探讨. 结果表明,利用微波辐射法合成含<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>3,4-<span style=\"color:red\">二</span>氢嘧啶类化合物具有反应时间短,产率高等优点.","authors":[{"authorName":"刘锦贵","id":"be79d055-97a3-4d24-bc38-8db2de54164a","originalAuthorName":"刘锦贵"},{"authorName":"王国辉","id":"b8bbf230-329c-4c78-bff9-85cff0fb1738","originalAuthorName":"王国辉"},{"authorName":"党珊","id":"ebd3f6dd-b394-4485-951d-e4951ada8c10","originalAuthorName":"党珊"}],"doi":"10.3969/j.issn.1000-0518.2009.10.016","fpage":"1206","id":"26f23ba2-7a8d-45c2-8be7-a8c1b534c210","issue":"10","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"24e2b2c9-cdd6-40f5-a0ad-0867007baf34","keyword":"三氯化铁","originalKeyword":"三氯化铁"},{"id":"45918397-c14c-4fbf-b69d-87384dd2f927","keyword":"Biginelli缩合反应","originalKeyword":"Biginelli缩合反应"},{"id":"a6d72b23-c996-4d81-a283-a7d328c42fe0","keyword":"<span style=\"color:red\">二</span>氢嘧啶","originalKeyword":"二氢嘧啶"},{"id":"9d2048d3-0296-4c5a-9562-89ede55752ab","keyword":"一锅合成","originalKeyword":"一锅合成"},{"id":"84c38a7c-fb55-4d38-b900-e71f89057cc0","keyword":"微波辐射","originalKeyword":"微波辐射"}],"language":"zh","publisherId":"yyhx200910016","title":"新型含<span style=\"color:red\">吡唑</span><span style=\"color:red\">基</span>3,4-<span style=\"color:red\">二</span>氢嘧啶类化合物的一锅合成","volume":"26","year":"2009"}],"totalpage":4482,"totalrecord":44815}