{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"以氯化亚锡为催化剂,L-乳酸(LA)与天冬酰胺(Asn)直接熔融聚合,所得生物材料聚(乳酸-天冬酰胺)[P(LA-co-Asn)]用[η]、红外光谱(FT-IR)、核磁共振(<'1>H-NMR)、凝胶渗透色谱(GPC)、差示扫描量热分析(DSC)、X射线衍射(XRD)等方法进行表征.随着投料比中Asn增加,共聚物由结晶性逐渐转变为无定型态,М<,W>逐渐降低(9,500～2,700),但能满足药物缓释要求.该合成方法经济、简单易行.与具有一定分支结构的聚(乳酸-天冬氨酸)相比,新型直链共聚物P(LA-co-Asn)侧链中伯酰胺可望进一步结合生物活性分子以改善聚乳酸的生物相容性.","authors":[{"authorName":"叶瑞荣","id":"772c1da6-d29b-4d09-ae63-1db3b91c87bd","originalAuthorName":"叶瑞荣"},{"authorName":"<span style=\"color:red\">罗</span><span style=\"color:red\">时</span><span style=\"color:red\">荷</span>","id":"e4c430ba-84e9-4ed2-ad7b-f4258e34610d","originalAuthorName":"罗时荷"},{"authorName":"汪朝阳","id":"5b1cb1ac-a5f8-4d54-b77b-448891020fdd","originalAuthorName":"汪朝阳"},{"authorName":"谭越河","id":"310cc181-62ef-43a7-8bf7-ca34215aa832","originalAuthorName":"谭越河"}],"doi":"","fpage":"141","id":"3f2ca143-8c18-46d3-a0b6-b708b5389e37","issue":"5","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"12087cd0-17b4-4a0a-930a-6dfcb68295d6","keyword":"乳酸","originalKeyword":"乳酸"},{"id":"b5c2f828-3c85-4848-9dd2-b229a52049bf","keyword":"天冬酰胺","originalKeyword":"天冬酰胺"},{"id":"15dca6b3-8bfb-499f-81a8-90a30df0fcb7","keyword":"聚(乳酸-co-天冬酰胺)","originalKeyword":"聚(乳酸-co-天冬酰胺)"},{"id":"de2f20d5-dc7b-4421-9e0f-afd9f3cfc021","keyword":"熔融聚合","originalKeyword":"熔融聚合"},{"id":"1865ec0e-d243-4143-9145-f5a416dc6fb0","keyword":"生物医学材料","originalKeyword":"生物医学材料"}],"language":"zh","publisherId":"gfzclkxygc201105037","title":"生物材料聚(乳酸-天冬酰胺)的制备与表征","volume":"27","year":"2011"},{"abstractinfo":"生物基小分子来源广、价廉,同时大多具有手性,使其在绿色化学盛行的今天作为良好的非介晶基元广泛应用于液晶材料合成研究领域.联苯类液晶因为其良好的物理化学稳定性、较宽的工作温度范围、适当的低黏度,以及快速响应与低电压驱动等优点,在光电显示材料等领域得到了广泛应用.文中综述了近年来薄荷醇、乳酸、糖醇、氨基酸等生物基小分子在联苯类液晶材料合成中的应用进展,指出多生物手性基团结合,特别是与高分子材料的完美组合,是未来研究的新方向.","authors":[{"authorName":"<span style=\"color:red\">罗</span><span style=\"color:red\">时</span><span style=\"color:red\">荷</span>","id":"a627d631-2e54-4e3c-8f2d-bb5070a7c6d4","originalAuthorName":"罗时荷"},{"authorName":"熊金锋","id":"262ba9e7-43c2-4a04-89bc-37ef6f5ad514","originalAuthorName":"熊金锋"},{"authorName":"彭湃","id":"2134f9ad-05bf-484d-b556-e0ff4504e893","originalAuthorName":"彭湃"},{"authorName":"汪朝阳","id":"7cb5dbfd-705f-44fd-9607-c302ea682645","originalAuthorName":"汪朝阳"}],"doi":"","fpage":"173","id":"5630f401-9759-408c-96f0-a469a1df80d9","issue":"5","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"ae0faf17-548f-4124-b88f-dfdc20fd0456","keyword":"生物基小分子","originalKeyword":"生物基小分子"},{"id":"a1156f22-612c-46c9-83e9-7a51a1969bd8","keyword":"联苯","originalKeyword":"联苯"},{"id":"e267aa5e-d970-4d6d-8a6d-d534b2716521","keyword":"液晶材料","originalKeyword":"液晶材料"},{"id":"cef8ffdd-4f37-43b8-8ab3-4e57f605f675","keyword":"合成","originalKeyword":"合成"}],"language":"zh","publisherId":"gfzclkxygc201305043","title":"生物基小分子在联苯类液晶材料合成中的应用进展","volume":"29","year":"2013"},{"abstractinfo":"以外消旋乳酸(D,L-LA)为单体,与L-谷氨酸(L-Glu)直接熔融聚合,合成了生物降解材料聚(乳酸-谷氨酸)共聚物.用特性粘数[η]、FTIR、1H NMR、GPC、DSC、XRD等手段进行系统表征,探讨了催化剂种类和用量、熔融聚合反应时间、反应温度以及不同投料比对聚合物合成的影响.在单体乳酸和谷氨酸投料物质的量比为98:2、150℃、70Pa、催化荆SnCl2的用量0.7%(质量分数)的条件下熔融聚合8h,聚合物重均相对分子质量(Mw)可达6400.随着谷氨酸投料量的增加,共聚物重均相对分子质量逐渐减小,Tg均低于直接熔融合成的聚外消旋乳酸,且共聚物均为无定形态.","authors":[{"authorName":"叶瑞荣","id":"d4bec6d3-88c0-45f1-9950-22d7fbf9e0c7","originalAuthorName":"叶瑞荣"},{"authorName":"汪朝阳","id":"66233e87-dbdb-44fe-a846-77903640c8de","originalAuthorName":"汪朝阳"},{"authorName":"莫阳青","id":"34c89b05-6f68-48d2-91ec-bb98fc9f287a","originalAuthorName":"莫阳青"},{"authorName":"<span style=\"color:red\">罗</span><span style=\"color:red\">时</span><span style=\"color:red\">荷</span>","id":"f3fafba5-a3db-48fc-add2-f5cd284084eb","originalAuthorName":"罗时荷"}],"doi":"","fpage":"94","id":"5bd8ff0f-c362-44f3-ad25-c2830dd263e6","issue":"8","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"758ab404-a8ef-467a-9a42-450800f54f92","keyword":"谷氨酸","originalKeyword":"谷氨酸"},{"id":"cd64cb7a-ce52-4915-a27a-37bb015a5892","keyword":"聚乳酸","originalKeyword":"聚乳酸"},{"id":"b77f404f-e19c-43aa-bd89-3178597361ee","keyword":"熔融聚合","originalKeyword":"熔融聚合"},{"id":"95dfa00c-cd0e-4f2a-b2c5-40ac6db3f528","keyword":"生物材料","originalKeyword":"生物材料"}],"language":"zh","publisherId":"cldb201008027","title":"熔融聚合法合成生物材料聚(乳酸-谷氨酸)","volume":"24","year":"2010"},{"abstractinfo":"气流粉碎作为超微粉体制备的一种先进技术被广泛运用在工业生产中，然而气流粉碎过程中颗粒间剧烈摩擦所形成的表面静电以及由于颗粒粒径减小所带来的强吸附性能，都将引起粉碎后的颗粒发生再次团聚，从而导致超微粉体的优良特性劣化。静电分散作为一种新型的物理分散法，通过使粉体颗粒在电晕电场中<span style=\"color:red\">荷</span>以同一极性的电荷，利用颗粒之间的库仑斥力进行分散，<span style=\"color:red\">荷</span>电量越大则粉体的分散性越好。以不同粒径的滑石粉为研究对象，对气流粉碎/静电分散相结合方法中粉体的<span style=\"color:red\">荷</span>电特性进行了实验研究。研究结果表明，平均粒径较大粉体的<span style=\"color:red\">荷</span>质比在较低气压下随着<span style=\"color:red\">荷</span>电电压的升高而增大，当气压较高<span style=\"color:red\">时</span>在40 kV下存在一峰值；而平均粒径较小粉体的<span style=\"color:red\">荷</span>质比均随着<span style=\"color:red\">荷</span>电电压的升高而增大。<span style=\"color:red\">荷</span>电电压恒定时滑石粉<span style=\"color:red\">荷</span>质比随着气流压强的增大而减小。相同<span style=\"color:red\">荷</span>电条件下粒径较小的粉体颗粒的<span style=\"color:red\">荷</span>电性能优于粒径较大颗粒。","authors":[{"authorName":"殷鹏飞","id":"df1c3acb-3d64-4814-98d3-48093a8b75f3","originalAuthorName":"殷鹏飞"},{"authorName":"张蓉","id":"79c8ae49-72f8-44ec-b3f9-a35146fd8201","originalAuthorName":"张蓉"},{"authorName":"李银冰","id":"21e9854b-f3af-4a2e-a772-73e269170417","originalAuthorName":"李银冰"},{"authorName":"李宁","id":"3e2bcc83-10aa-44a3-b206-82eea4adc3ed","originalAuthorName":"李宁"},{"authorName":"王佳佳","id":"f6deb8f1-67eb-4495-9935-320822c6cb7f","originalAuthorName":"王佳佳"},{"authorName":"胡建昌","id":"ebc41303-b065-4a43-b35e-de08fb9ec468","originalAuthorName":"胡建昌"}],"doi":"10.3969/j.issn.1001-9731.2014.05.023","fpage":"5102","id":"43adf9c8-b336-4d35-9f6a-d730ee6dec30","issue":"5","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"c6709ffa-dadd-4bad-91ea-6bb0b17a2714","keyword":"超微粉体","originalKeyword":"超微粉体"},{"id":"2e833315-50cc-4995-97f6-338cae623f9e","keyword":"<span style=\"color:red\">荷</span>电特性","originalKeyword":"荷电特性"},{"id":"9bd43e7c-fb64-4a00-b16b-0ccb92a7a94b","keyword":"气流粉碎","originalKeyword":"气流粉碎"},{"id":"63f2790f-6003-4026-89c8-eaf5df3b179e","keyword":"静电分散","originalKeyword":"静电分散"}],"language":"zh","publisherId":"gncl201405023","title":"气流粉碎/静电分散中超微粉体<span style=\"color:red\">荷</span>电特性的实验研究","volume":"","year":"2014"},{"abstractinfo":"自制法拉第杯测量装置,测量粉末颗粒在不同直流电晕方式人工<span style=\"color:red\">荷</span>电<span style=\"color:red\">时</span><span style=\"color:red\">荷</span>电量.试验并分析了测量的诸多干扰因素及屏蔽问题,采用杯上覆盖接地金属网可有效屏蔽电极等干扰.","authors":[{"authorName":"张宝峰","id":"b9c2b63c-a95e-433b-ad82-676782917f94","originalAuthorName":"张宝峰"},{"authorName":"张连洪","id":"79d2fa29-c9f5-460f-bf66-2ecb0486d24e","originalAuthorName":"张连洪"},{"authorName":"李双义","id":"13804e0a-dd7c-4477-9cbd-cdab2a58edf6","originalAuthorName":"李双义"},{"authorName":"刘卫京","id":"3c051dfc-99d4-4050-bea1-bb3d30882140","originalAuthorName":"刘卫京"}],"doi":"10.3969/j.issn.1001-0777.2003.03.006","fpage":"15","id":"ae385837-aff6-40b5-8dd2-59fef3ebd72b","issue":"3","journal":{"abbrevTitle":"WLCS","coverImgSrc":"journal/img/cover/WLCS.jpg","id":"64","issnPpub":"1001-0777","publisherId":"WLCS","title":"物理测试"},"keywords":[{"id":"7766f273-ded4-418d-82cb-2595581ff800","keyword":"快速成型","originalKeyword":"快速成型"},{"id":"15821f42-f2c0-4aa6-a329-977d801f1564","keyword":"人工<span style=\"color:red\">荷</span>电","originalKeyword":"人工荷电"},{"id":"cb394abb-87a4-4e94-80f7-7ebee2ac35fa","keyword":"法拉第杯","originalKeyword":"法拉第杯"},{"id":"e3e7dd3c-c868-4d41-aa05-670e85219f18","keyword":"电场屏蔽","originalKeyword":"电场屏蔽"}],"language":"zh","publisherId":"wlcs200303006","title":"法拉第杯直接测量颗粒<span style=\"color:red\">荷</span>电量的屏蔽问题","volume":"","year":"2003"},{"abstractinfo":"以微孔硅藻土陶瓷膜为基膜,YC13和NaOH反应制备的纳米Y2O3为<span style=\"color:red\">荷</span>电剂,经浸渍-热分解法制备<span style=\"color:red\">荷</span>正电微孔陶瓷膜.通过TGA、SEM、EDS、Zeta电位分析等手段对其组成和结构进行表征.结果显示,制备<span style=\"color:red\">荷</span>电剂的煅烧温度为700℃<span style=\"color:red\">时</span>,前驱体完全转化为纳米Y2O3,平均粒径约为118 nm,且Y2O3晶粒生长良好;<span style=\"color:red\">荷</span>电膜微孔结构保持良好,纳米Y2O3均匀地附着在基膜表面;<span style=\"color:red\">荷</span>电膜在pH为4～8范围内带正电性,其等电点为8.11.<span style=\"color:red\">荷</span>电膜的正电性能预示着其在去除水中带负电荷的细菌、病毒及有机染料等方面具有很大的应用前景.","authors":[{"authorName":"张莉莉","id":"01bf3f1d-de0e-4793-b41d-9590bb9dd90b","originalAuthorName":"张莉莉"},{"authorName":"朱孟府","id":"fd582909-4182-4c88-8856-5537f425dc81","originalAuthorName":"朱孟府"},{"authorName":"程秀婷","id":"866b961a-83ad-45e9-9ef3-10be8e42ae15","originalAuthorName":"程秀婷"},{"authorName":"邓宇","id":"45fb0680-1619-43ab-a55d-ecd4b614778a","originalAuthorName":"邓宇"},{"authorName":"邓橙","id":"4ddc06e3-b344-41d7-9348-75f1ad454c9c","originalAuthorName":"邓橙"}],"doi":"10.16159/j.cnki.issn1007-8924.2016.03.004","fpage":"21","id":"99e7daea-527e-4d5b-800b-8e7b181560a1","issue":"3","journal":{"abbrevTitle":"MKXYJS","coverImgSrc":"journal/img/cover/MKXYJS.jpg","id":"54","issnPpub":"1007-8924","publisherId":"MKXYJS","title":"膜科学与技术   "},"keywords":[{"id":"57cd0449-7e46-4715-b7de-b2d8dad578c3","keyword":"正电性","originalKeyword":"正电性"},{"id":"510fa432-9a60-413d-a2a8-bf6030375841","keyword":"微孔陶瓷膜","originalKeyword":"微孔陶瓷膜"},{"id":"5fe06668-3e47-4c84-9888-33bfba6b8d88","keyword":"浸渍-热分解法","originalKeyword":"浸渍-热分解法"},{"id":"ed796a55-cff7-4b5c-be31-a71694ed7056","keyword":"纳米Y2O3","originalKeyword":"纳米Y2O3"}],"language":"zh","publisherId":"mkxyjs201603004","title":"浸渍-热分解法制备<span style=\"color:red\">荷</span>正电微孔陶瓷膜","volume":"36","year":"2016"},{"abstractinfo":"提出了一种利用静电低压撞击器(ELPI)测量颗粒物分级<span style=\"color:red\">荷</span>电量的新方法,利用此方法可以将每种颗粒在0.03～10μm范围内按其动力学粒径分为12级,然后可以获得每一级粒径的单个颗粒的平均<span style=\"color:red\">荷</span>电量.应用此方法首次实际测量了3种飞灰在自然<span style=\"color:red\">荷</span>电与强制<span style=\"color:red\">荷</span>电两种工况下的分级<span style=\"color:red\">荷</span>电量,获得了比较合理的结果,结果显示飞灰主要<span style=\"color:red\">荷</span>负电,且小于1μm的飞灰颗粒的<span style=\"color:red\">荷</span>电量随粒径变化不大,而大于1 μm的颗粒的<span style=\"color:red\">荷</span>电量随粒径增加迅速增加.","authors":[{"authorName":"龙正伟","id":"c49fd0f9-dd2b-41f7-89ef-961e90436d7f","originalAuthorName":"龙正伟"},{"authorName":"姚强","id":"5d9a8502-7b4e-4a28-a5f4-e200a0985177","originalAuthorName":"姚强"},{"authorName":"黄斌","id":"429bf6cc-fe9b-4387-8234-382c07f1b40e","originalAuthorName":"黄斌"},{"authorName":"宋蔷","id":"e4291382-5df8-4bc1-a3a6-9a19e49aeffc","originalAuthorName":"宋蔷"}],"doi":"","fpage":"354","id":"e367c8e5-b8ec-4f35-8d50-d4c8f392e86f","issue":"2","journal":{"abbrevTitle":"GCRWLXB","coverImgSrc":"journal/img/cover/GCRWLXB.jpg","id":"32","issnPpub":"0253-231X","publisherId":"GCRWLXB","title":"工程热物理学报   "},"keywords":[{"id":"f86b0860-d972-455a-b84b-f999fed19dba","keyword":"ELPI","originalKeyword":"ELPI"},{"id":"8834b486-3634-4d23-a1f2-29d472ad54b9","keyword":"中和器","originalKeyword":"中和器"},{"id":"549217b6-d2d6-42d7-a133-f3a6f2f56b02","keyword":"电晕","originalKeyword":"电晕"},{"id":"3fc94dba-b596-4b3f-a40e-f9121172f15e","keyword":"气溶胶","originalKeyword":"气溶胶"},{"id":"75ded120-9465-48da-87f0-455d4f945cbd","keyword":"颗粒<span style=\"color:red\">荷</span>电量","originalKeyword":"颗粒荷电量"}],"language":"zh","publisherId":"gcrwlxb200602055","title":"用ELPI测量颗粒物的分级<span style=\"color:red\">荷</span>电量","volume":"27","year":"2006"},{"abstractinfo":"研究了不同<span style=\"color:red\">荷</span>电量小分子(分子量为1 kD左右)通过表面带同种电荷但<span style=\"color:red\">荷</span>电量不同的超滤膜(截留分子量为10 kD)<span style=\"color:red\">时</span>的行为.实验结果表明,<span style=\"color:red\">荷</span>电超滤膜对带电小分子的截留作用与超滤膜<span style=\"color:red\">荷</span>电量、小分子带电量以及溶液离子强度密切相关.低离子强度条件下,<span style=\"color:red\">荷</span>电超滤膜对高<span style=\"color:red\">荷</span>电小分子的截留率很高,这主要是静电相互作用的结果.随着离子强度的增加,静电屏蔽作用增强,<span style=\"color:red\">荷</span>电超滤膜对带电小分子的截留作用也相应减小.结果还表明,表观透过率的实验值与基于滞膜模型的理论计算值有较好的吻合.","authors":[{"authorName":"王来欢","id":"c57ae899-65c8-4b06-b8fe-3d0a4e7360d7","originalAuthorName":"王来欢"},{"authorName":"邵嘉慧","id":"38a877c4-544c-4cdf-8df4-d969b2f8362c","originalAuthorName":"邵嘉慧"},{"authorName":"何义亮","id":"23904257-74f9-42b8-a163-b6fc88b0584b","originalAuthorName":"何义亮"}],"doi":"10.3969/j.issn.1007-8924.2009.02.012","fpage":"60","id":"c159ff01-df12-410d-ba3a-36fcd96ffde5","issue":"2","journal":{"abbrevTitle":"MKXYJS","coverImgSrc":"journal/img/cover/MKXYJS.jpg","id":"54","issnPpub":"1007-8924","publisherId":"MKXYJS","title":"膜科学与技术   "},"keywords":[{"id":"584ff667-2862-448c-b31a-7ba902ca0a81","keyword":"静电相互作用","originalKeyword":"静电相互作用"},{"id":"25d25859-7791-4d34-a80f-d7b287cda183","keyword":"超滤","originalKeyword":"超滤"},{"id":"f6b85f53-c001-4187-a626-80d2f57203c0","keyword":"全过滤","originalKeyword":"全过滤"},{"id":"7f855fa4-b234-44fd-88ab-c4f172f514f4","keyword":"透过率","originalKeyword":"透过率"},{"id":"40992158-76e2-4b2a-a930-396872ce6f18","keyword":"杂质去除","originalKeyword":"杂质去除"}],"language":"zh","publisherId":"mkxyjs200902012","title":"静电相互作用对<span style=\"color:red\">荷</span>电超滤过程中带电小分子清除的影响","volume":"29","year":"2009"},{"abstractinfo":"建立了猪组织中克伦特<span style=\"color:red\">罗</span>的高效液相色谱-电化学检测方法.色谱柱为Discovery C18柱(5 μm,4.6 mm i.d.×250 mm);流动相为1.7 mmol/L氯化锂-甲酸-甲醇(体积比为65∶1∶34)混合溶液,流速为1.0 mL/min;柱温为40.0 ℃;电化学检测器工作电位为1.25 V.猪组织中克伦特<span style=\"color:red\">罗</span>含量为0.5～500 ng/g <span style=\"color:red\">时</span>,克伦特<span style=\"color:red\">罗</span>的含量与其峰面积之间存在良好的线性关系(r＞0.99),在组织中按0.5,50,500 ng/g 3个添加水平做克伦特<span style=\"color:red\">罗</span>的回收率试验,其回收率为75.8%～87.1%(n=4).该方法重现性好,灵敏度高,简便,可用于猪的肌肉、肺脏、肝脏、肾脏及脂肪组织中克伦特<span style=\"color:red\">罗</span>残留的检测.","authors":[{"authorName":"杨志凌","id":"92223368-ba02-42e0-91c0-07f9481747f7","originalAuthorName":"杨志凌"},{"authorName":"陈杖榴","id":"abec9d48-2521-46ca-900f-7065497c701c","originalAuthorName":"陈杖榴"},{"authorName":"方炳虎","id":"8e8ecd49-1755-4110-b71c-44b1bb053f33","originalAuthorName":"方炳虎"},{"authorName":"曾振灵","id":"9b8daa16-55c3-46de-bec6-2d148c128d8e","originalAuthorName":"曾振灵"},{"authorName":"丁焕中","id":"6019df66-87a3-44d9-a40a-fd8b30019654","originalAuthorName":"丁焕中"}],"doi":"10.3321/j.issn:1000-8713.2003.03.014","fpage":"245","id":"9094f299-fcc1-443c-9daa-9df60c8544c2","issue":"3","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"05b2736a-dbb1-4991-8b42-ebeaffd7d103","keyword":"高效液相色谱法","originalKeyword":"高效液相色谱法"},{"id":"8fcb87cd-adf6-4626-98db-ffaa1002aa33","keyword":"电化学检测","originalKeyword":"电化学检测"},{"id":"095ca318-16c4-476e-b529-d8d7dd547de1","keyword":"克伦特<span style=\"color:red\">罗</span>","originalKeyword":"克伦特罗"},{"id":"1831e554-5545-44af-aa86-0cdb57379d62","keyword":"猪组织","originalKeyword":"猪组织"}],"language":"zh","publisherId":"sp200303014","title":"高效液相色谱-电化学检测法测定猪组织中的克伦特<span style=\"color:red\">罗</span>","volume":"21","year":"2003"},{"abstractinfo":"建立了一种简单、快速测定<span style=\"color:red\">罗</span>哌卡因血药浓度的反相高效液相色谱法。在血清样品中加入布比卡因作内标,用二氯甲烷提取,氮气吹干,残渣用流动相溶解进样。色谱条件:分析柱为C18反相柱,流动相为0.01 mol*L-1磷酸二氢钾(pH 3.0)-乙腈(体积比为84∶16)溶液,流速为1.2 mL*min-1, 在紫外检测波长210 nm处进行检测。<span style=\"color:red\">罗</span>哌卡因及内标在11 min内完全分离,最低检测质量浓度为0.025 mg*L-1,在0.05 mg*L-1～ 2.50 mg*L-1<span style=\"color:red\">时</span>线性关系良好,r=0.9997,低、中、高浓度下的回收率、日间及日内精密度均符合方法学要求。方法简便、快速、稳定、重现性好,可以用于<span style=\"color:red\">罗</span>哌卡因血药浓度的临床监护及药代动力学的研究。","authors":[{"authorName":"张春燕","id":"b89bcfc3-6f70-4ec3-a864-555cf7ba130b","originalAuthorName":"张春燕"},{"authorName":"顾健","id":"748d791b-5f28-488e-a4fa-86fd9c5d9e42","originalAuthorName":"顾健"},{"authorName":"段金菊","id":"8904f19b-46fa-4841-bebe-b995d5e8d493","originalAuthorName":"段金菊"},{"authorName":"钟蕾","id":"f019fb9a-d963-44ec-9c3f-324515e57ead","originalAuthorName":"钟蕾"},{"authorName":"李玉珍","id":"d84b2cd1-832c-43a8-96c1-31bead020064","originalAuthorName":"李玉珍"}],"doi":"10.3321/j.issn:1000-8713.2002.01.014","fpage":"56","id":"5c6d5c4b-38b8-46ca-bb74-7548856efac0","issue":"1","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"ce0e2497-4621-4b59-870a-57424b569797","keyword":"反相高效液相色谱法","originalKeyword":"反相高效液相色谱法"},{"id":"bf67aa03-336c-42ae-a6fe-36d482375d79","keyword":"<span style=\"color:red\">罗</span>哌卡因","originalKeyword":"罗哌卡因"},{"id":"1c6d9e4b-b90b-4ef7-9abc-affc35bba231","keyword":"血清","originalKeyword":"血清"}],"language":"zh","publisherId":"sp200201014","title":"反相高效液相色谱法测定人血清中的<span style=\"color:red\">罗</span>哌卡因","volume":"20","year":"2002"}],"totalpage":4852,"totalrecord":48511}