Honglian DAI
,
Shipu LI
,
Yuhua YAN
,
Xianying CAO
,
Xuehui LU
,
Yang LENG
材料科学技术（英）
To study the osteogenesis and transformation process of calcium phosphate bioceramic in vivo, biodegradable porous beta-tricalcium phosphate ceramics (β-TCP, 5×8 mm) were implanted in the tibia of rabbits. β-TCP ceramics with surrounding bone tissue were retrieved and observed by SEM, TEM and EPMA every month after implantation. The results showed that osteogenesis was active and β-TCP ceramics bonded to bones directly. The new bones were forming and maturing as materials were continuously degrading, and materials were finally replaced by new bone. Parts of the materials were degraded, absorbed and recrystallized, while the rest were dispersed to the spongy bone and the Haversian lamella in an irregular arrangement, becoming incorporated into bone formation directly by remodeling the structure. Some β-TCP crystals cleaved along its (001) rhombohedral plane and formed lath-like crystals in vivo.
关键词:
Calcium phosphate ceramics
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Honglian DAI
,
Xianying CAO
,
Haichen SHAO
,
Chunhua SHEN
,
Shipu LI
材料科学技术（英）
Electron probe and X-ray energy spectrum were used to investigate the chemical composition of the interface between material and new bone after porous tricalcium phosphate ceramic implanted in tibia of rabbits. The element changes of the interface, the materials transformation and the situation of new bone formation at different implantation period were observed. The results showed that the carbon element content decreased gradually in new bone tissue, and the content of calcium and phosphor element increased by degrees with the implantation time. At the same time, calcium-phosphor ratio in the new bone kept a higher level. New bone grew into the materials interior, material dispersed and degraded simultaneously. Both composition of materials and new bone tended to be consentient. Finally, the materials were substituted by new bone. After implantation, not only the materials itself dissolved and degraded partially, but also new bone formed on the outer and pore surface of β-TCP porous bioceramics, which showed that the degradation products of lifeless calcium phosphate inorganic materials took part in constituting of new bone tissue.
关键词:
Calcium phosphate
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