{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"蚕丝<span style=\"color:red\">丝素材料</span>植入体内后的降解可直接造成其形态和结构变化、力学性能和质量下降.降解产物与组织反应或全身反应的程度密切相关.用于组织工程和再生医学的<span style=\"color:red\">丝素</span>支架<span style=\"color:red\">材料</span>的生物降解速率应与组织再生速率相匹配;用于药物控制释放系统的<span style=\"color:red\">丝素</span>载体的生物降解速率应与生物活性物质的释放需要相适应.概述了近年来对<span style=\"color:red\">丝素材料</span>生物降解问题的研究现状,介绍了通过体外、体内实验所观察到的<span style=\"color:red\">丝素材料</span>生物降解行为,包括天然<span style=\"color:red\">丝素</span>纤维、再生<span style=\"color:red\">丝素</span>纤维、<span style=\"color:red\">多孔</span>支架及薄膜等,总结了未来需要进一步研究的问题.指出蚕丝<span style=\"color:red\">丝素</span>作为一种蛋白质可被多种蛋白酶催化水解;天然<span style=\"color:red\">丝素</span>纤维比再生<span style=\"color:red\">丝素材料</span>的生物降解速率慢;<span style=\"color:red\">丝素</span>的分子构象、结晶度、交联程度、<span style=\"color:red\">材料</span>的形态等对<span style=\"color:red\">丝素</span>的降解速率有明显影响;建立预测<span style=\"color:red\">丝素材料</span>生物降解程度与其功能变化以及与机体应答关系的研究模型和技术,有效调控其生物降解速率,将是未来的研究方向.","authors":[{"authorName":"李明忠","id":"589d77c7-0b4a-445f-8df1-f23b6c3b0f06","originalAuthorName":"李明忠"},{"authorName":"张剑","id":"8c4dca8a-a2d0-4c66-b5ad-745a853a56a1","originalAuthorName":"张剑"},{"authorName":"邱玉华","id":"9a432ded-1121-4c75-b6cb-e29e3ed62fdc","originalAuthorName":"邱玉华"},{"authorName":"卢神州","id":"e56b17a1-844c-4ad5-8e9b-4ae93f5eb861","originalAuthorName":"卢神州"}],"doi":"10.7502/j.issn.1674-3962.2015.07.11","fpage":"565","id":"fb796443-c2c0-4559-afcd-6e9daad7dfa0","issue":"7","journal":{"abbrevTitle":"ZGCLJZ","coverImgSrc":"journal/img/cover/中国材料进展.jpg","id":"80","issnPpub":"1674-3962","publisherId":"ZGCLJZ","title":"中国材料进展"},"keywords":[{"id":"8d82a4c8-2136-492d-9ee6-d7da6a1efd29","keyword":"蚕丝","originalKeyword":"蚕丝"},{"id":"e7709a0b-4ae1-4a3f-813d-db62876844bb","keyword":"<span style=\"color:red\">丝素</span>","originalKeyword":"丝素"},{"id":"495e465c-f961-44f1-af9b-6e89760adac3","keyword":"生物降解","originalKeyword":"生物降解"},{"id":"22eff4c7-81ad-4b18-b4f6-00b1c0622d76","keyword":"蛋白酶","originalKeyword":"蛋白酶"},{"id":"afbbce0b-62f7-44cc-a177-b344c57f1a53","keyword":"<span style=\"color:red\">丝素</span><span style=\"color:red\">多孔</span><span style=\"color:red\">材料</span>","originalKeyword":"丝素多孔材料"}],"language":"zh","publisherId":"zgcljz201507011","title":"蚕丝<span style=\"color:red\">丝素材料</span>的生物降解性能","volume":"34","year":"2015"},{"abstractinfo":"以<span style=\"color:red\">丝素</span>和羟基磷灰石为基材,磷酸盐缓冲液为溶剂,戊二醛为交联剂制备<span style=\"color:red\">丝素</span>/羟基磷灰石支架<span style=\"color:red\">材料</span>,对<span style=\"color:red\">丝素</span>生物<span style=\"color:red\">材料</span>在骨<span style=\"color:red\">材料</span>中的开发应用有积极意义。研究表明,<span style=\"color:red\">丝素</span>/羟基磷灰石复合<span style=\"color:red\">材料</span>具有结晶结构和β构象。当<span style=\"color:red\">丝素</span>与羟基磷灰石的比例为6/4时,支架<span style=\"color:red\">材料</span>的弹性模量和压缩强度达到最大,分别为48.087 MPa和1.427 MPa,孔隙率为70%,支架孔径50μm~200μm。利用该方法制备获得的支架<span style=\"color:red\">材料</span>,力学性能有明显提高,与人体<span style=\"color:red\">多孔</span>骨的结构接近。","authors":[{"authorName":"徐水","id":"2921e8e1-1c0a-42c5-a460-4ea948de100d","originalAuthorName":"徐水"},{"authorName":"张胡静","id":"78adfdd4-20ee-41fc-9968-8b2b450fe8e5","originalAuthorName":"张胡静"},{"authorName":"张海萍","id":"277119cb-a5de-4100-b65d-01318f162b54","originalAuthorName":"张海萍"},{"authorName":"杨明英","id":"4940ba62-bb8c-48db-ae3b-9ea6755b8de5","originalAuthorName":"杨明英"},{"authorName":"朱良均","id":"7cb15292-d268-4875-91a3-f88b31af6b7b","originalAuthorName":"朱良均"}],"doi":"","fpage":"150","id":"9b20de4c-d0a8-4513-ac25-ed94e15d0d44","issue":"10","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"f7b08485-39fa-49e5-b960-c7a7ede4464a","keyword":"<span style=\"color:red\">丝素</span>","originalKeyword":"丝素"},{"id":"95d79324-ffe5-4380-a0f1-51e81082d9b4","keyword":"羟基磷灰石","originalKeyword":"羟基磷灰石"},{"id":"909e7375-611b-47c0-b61b-11d89c680cba","keyword":"支架","originalKeyword":"支架"},{"id":"8e0510a8-f8a4-4aff-9924-d6bf32f822a1","keyword":"结构","originalKeyword":"结构"},{"id":"593d5267-b0a4-4c19-8435-649206e93822","keyword":"力学性能","originalKeyword":"力学性能"}],"language":"zh","publisherId":"gfzclkxygc201110046","title":"高强度力学性能<span style=\"color:red\">丝素</span>/羟基磷灰石<span style=\"color:red\">多孔</span>支架<span style=\"color:red\">材料</span>的初步制备","volume":"27","year":"2011"},{"abstractinfo":"采用水刺法制备了<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>蛋白(SF)支架,通过原位矿化法制备了纳米羟基磷灰石(HAP)/<span style=\"color:red\">丝素</span>蛋白复合<span style=\"color:red\">材料</span>.HAP 呈现均匀棒状结构,而没有<span style=\"color:red\">丝素</span>蛋白支架时 HAP 仅形成颗粒状结构,这表明蛋白支架可诱导 HAP 形成均匀棒状结构,这可能是源于<span style=\"color:red\">丝素</span>蛋白中羧基和溶液中 Ca2＋的静电作用；<span style=\"color:red\">丝素</span>蛋白支架起到了复合<span style=\"color:red\">材料</span>基材和 HAP 原位生长的高分子模板双重作用.采用红外光谱、X 射线衍射和力学性能测试对复合<span style=\"color:red\">材料</span>的结构性能进行了表征,红外谱图表明,HAP 中的 PO 3－4与 SF 中的—NH 2存在强烈的氢键相互作用,而 X 射线衍射图谱则表明复合<span style=\"color:red\">材料</span>中 SF 的保持了β折叠结构和结晶性能,使得复合<span style=\"color:red\">材料</span>具有良好的力学性能和<span style=\"color:red\">多孔</span>性能,有利于成骨细胞在支架上的增殖,同时,该方法制备的复合<span style=\"color:red\">材料</span>力学性能好,可大面积制备,成本低、制备方便,易于实现工业化,可望广泛用于骨修复支架<span style=\"color:red\">材料</span>.","authors":[{"authorName":"光善仪","id":"e8d50682-0b48-46f6-b209-c513251b1f79","originalAuthorName":"光善仪"},{"authorName":"柯福佑","id":"b99a1a22-6b07-43ee-8edd-75ea38799ae3","originalAuthorName":"柯福佑"},{"authorName":"沈玉华","id":"1bc15a30-2878-4ca1-a349-7ea5ad8482ea","originalAuthorName":"沈玉华"}],"doi":"10.3969/j.issn.1001-9731.2015.22.031","fpage":"22149","id":"19c6af6a-f8c5-4d3a-befd-5aab46643e30","issue":"22","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"65ccb737-3ed7-4252-bb6b-400f100cd0a2","keyword":"羟基磷灰石","originalKeyword":"羟基磷灰石"},{"id":"116accf5-2399-4f5b-bba3-37e027c57663","keyword":"<span style=\"color:red\">丝素</span>蛋白","originalKeyword":"丝素蛋白"},{"id":"8fe33c1b-a163-47a7-aad2-170e2f558c40","keyword":"复合<span style=\"color:red\">材料</span>","originalKeyword":"复合材料"},{"id":"30040e3a-38c7-4f17-8d3a-fa4d8c0c8ab0","keyword":"制备","originalKeyword":"制备"}],"language":"zh","publisherId":"gncl201522031","title":"非织造<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>蛋白/纳米羟基磷灰石复合支架<span style=\"color:red\">材料</span>的制备和表征?","volume":"","year":"2015"},{"abstractinfo":"采用硝酸钙-<span style=\"color:red\">丝素</span>蛋白溶液与磷酸钠反应仿生合成纳米羟基磷灰石/<span style=\"color:red\">丝素</span>蛋白(n-HA/SF)复合<span style=\"color:red\">材料</span>,并以NaHCO3和NaCl为致孔剂制备了<span style=\"color:red\">多孔</span>复合支架<span style=\"color:red\">材料</span>,采用TEM、IR、SEM和EDX对其进行了表征.结果表明,复合<span style=\"color:red\">材料</span>中HA的粒径在20～50nm之间,是一种CO2-3部分替代型弱结晶类骨针晶,在形貌和尺寸等方面类似于人体骨磷灰石晶体;HA和SF两相间存在强烈的键合作用,复合支架<span style=\"color:red\">材料</span>呈高度<span style=\"color:red\">多孔</span>结构,孔壁上富含微孔,孔隙间贯通性高.EDX分析结果表明,HA在有机基体中分布均匀,钙磷元素比为1.66,当复合<span style=\"color:red\">材料</span>和致孔剂的比例为1:0.5时,其抗压强度可达20.23MPa.","authors":[{"authorName":"王江","id":"ccd16197-01eb-4a4e-9230-05beab273e7b","originalAuthorName":"王江"},{"authorName":"李玉宝","id":"83fe3511-c317-4eb9-a893-04be1f419b32","originalAuthorName":"李玉宝"},{"authorName":"左奕","id":"541e5e32-328a-4a12-9813-a1e94533a7ba","originalAuthorName":"左奕"},{"authorName":"杨维虎","id":"c9ff7672-e03c-4371-9af1-8d20183e3993","originalAuthorName":"杨维虎"},{"authorName":"张利","id":"a83ed66f-3d5c-4aca-b3c1-c47275219122","originalAuthorName":"张利"}],"doi":"","fpage":"1714","id":"ce7920ba-8f5b-4b88-b3dc-d1ea72e41d97","issue":"10","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"c3c6afc2-7762-4874-ac5d-7f42a9979f78","keyword":"纳米羟基磷灰石","originalKeyword":"纳米羟基磷灰石"},{"id":"cec18120-dad5-4e8d-97d6-69b3e7810a8a","keyword":"<span style=\"color:red\">丝素</span>蛋白","originalKeyword":"丝素蛋白"},{"id":"17f4639b-52a2-4791-8dec-4139aafa0bd4","keyword":"仿生合成","originalKeyword":"仿生合成"},{"id":"a08a4680-fdd7-4e47-b5df-e08170e3d72b","keyword":"复合<span style=\"color:red\">材料</span>","originalKeyword":"复合材料"},{"id":"19f41727-ed06-4af9-a021-791615179ace","keyword":"<span style=\"color:red\">多孔</span>支架<span style=\"color:red\">材料</span>","originalKeyword":"多孔支架材料"}],"language":"zh","publisherId":"gncl200810036","title":"纳米羟基磷灰石/<span style=\"color:red\">丝素</span>蛋白<span style=\"color:red\">多孔</span>支架<span style=\"color:red\">材料</span>的制备和表征","volume":"39","year":"2008"},{"abstractinfo":"报道了以下研究:研制成含抗菌药物的<span style=\"color:red\">丝素</span>膜,它用于创面保护,能防止感染,加速创面愈合;研制成<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>膜,并研究了它们的结构和性能,<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>膜能用作细胞培养的支架、药物缓释剂等;设计和研制成<span style=\"color:red\">丝素</span>成膜设备,该设备能用以生产<span style=\"color:red\">丝素</span>创面保护膜及其他医用膜.","authors":[{"authorName":"国家高技术新<span style=\"color:red\">材料</span>领域 <span style=\"color:red\">丝素</span>蛋白作为生物医学<span style=\"color:red\">材料</span>的应用研究和产品开发课题组","id":"d3a9c85e-c719-41c2-b375-a6c3b60a977c","originalAuthorName":"国家高技术新材料领域 丝素蛋白作为生物医学材料的应用研究和产品开发课题组"}],"doi":"","fpage":"63","id":"cd57d14f-3225-4b11-bde2-e196944a30bb","issue":"9","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"30ec1982-962f-4b78-8c8b-85819baeb2bf","keyword":"<span style=\"color:red\">丝素</span>膜","originalKeyword":"丝素膜"},{"id":"ec49159e-79d3-4a9d-8597-ceaf2dbec8b2","keyword":"抗菌药物","originalKeyword":"抗菌药物"},{"id":"9d06adda-7e48-4569-8314-f562e372729b","keyword":"<span style=\"color:red\">多孔</span><span style=\"color:red\">材料</span>","originalKeyword":"多孔材料"},{"id":"0a727577-6670-434c-9e37-51aa5c5cd548","keyword":"成膜设备","originalKeyword":"成膜设备"}],"language":"zh","publisherId":"cldb200009021","title":"<span style=\"color:red\">丝素</span>蛋白作为生物医用<span style=\"color:red\">材料</span>的研究","volume":"14","year":"2000"},{"abstractinfo":"以冷冻干燥法制备<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>(SF)支架,利用层层自组装将纳米纤维素晶须(CNW)和壳聚糖(CS)交替组装到<span style=\"color:red\">多孔</span>SF支架上得到SF/CNW-CS<span style=\"color:red\">多孔</span>复合支架.对SF/CNW-CS<span style=\"color:red\">多孔</span>复合支架的形貌和机械性能进行了表征.以MG-63细胞进行体外培养评估SF及SF/CNW-CS<span style=\"color:red\">多孔</span>复合支架的细胞相容性,MTT比色法和荧光图像的测试结果表明,与SF<span style=\"color:red\">多孔</span>支架相比,MG-63细胞在SF/CNW-CS<span style=\"color:red\">多孔</span>复合支架上的增殖、粘附和分化功能最高.因此,SF/CNW-CS支架有望成为骨组织工程的理想<span style=\"color:red\">材料</span>.","authors":[{"authorName":"谭卫琳","id":"370822ff-7a82-4e6d-913b-975e052fc59b","originalAuthorName":"谭卫琳"},{"authorName":"张琦","id":"5d15c055-df03-4531-9fe1-c680fc1c73dd","originalAuthorName":"张琦"},{"authorName":"何健新","id":"ca411f96-460e-4cb7-bbb6-5ed916237e80","originalAuthorName":"何健新"},{"authorName":"韩啟明","id":"c75900b5-432d-4b70-aef9-d8c530d864fd","originalAuthorName":"韩啟明"},{"authorName":"崔世忠","id":"34df379e-e582-4305-bbff-971ecbe3fbe9","originalAuthorName":"崔世忠"},{"authorName":"邵伟力","id":"20bd3b23-65b9-405c-8f9d-6cf0cf15dc2c","originalAuthorName":"邵伟力"}],"doi":"10.14136/j.cnki.issn 1673-2812.2015.06.019","fpage":"868","id":"b61fdb02-f153-4565-9d0a-511ebc2c85ba","issue":"6","journal":{"abbrevTitle":"CLKXYGCXB","coverImgSrc":"journal/img/cover/CLKXYGCXB.jpg","id":"13","issnPpub":"1673-2812","publisherId":"CLKXYGCXB","title":"材料科学与工程学报"},"keywords":[{"id":"1251ee64-8c30-4847-bd7b-4da35dd80902","keyword":"<span style=\"color:red\">多孔</span><span style=\"color:red\">丝素</span>支架(SF)","originalKeyword":"多孔丝素支架(SF)"},{"id":"b4b4d5fc-441b-44e0-8a05-ba15dc6df698","keyword":"纳米纤维素晶须(CNW)","originalKeyword":"纳米纤维素晶须(CNW)"},{"id":"c64eee72-dd41-4566-9cf0-ab4c93c8406a","keyword":"层层自组装","originalKeyword":"层层自组装"},{"id":"ff1e6e78-b73f-4bc9-b0cb-c8fe62d0bfd7","keyword":"骨组织工程","originalKeyword":"骨组织工程"}],"language":"zh","publisherId":"clkxygc201506019","title":"<span style=\"color:red\">丝素</span>/纳米纤维素晶须/壳聚糖<span style=\"color:red\">多孔</span>复合支架的应用","volume":"33","year":"2015"},{"abstractinfo":"应用冷冻干燥技术,在不同预冻温度下制备不同质量比的三维<span style=\"color:red\">多孔</span>支架,用扫描电镜观察支架的微观形貌,X射线衍射仪分析其表面相结构,并测定了其吸水率、孔隙率和热稳定性,观察不同质量比和预冻温度对<span style=\"color:red\">丝素</span>(silk fibroin,SF)/明胶(gelatin,G)三维<span style=\"color:red\">多孔</span>支架结构和性能的影响。结果显示,通过改变<span style=\"color:red\">材料</span>的质量比和预冻温度可以控制支架的孔隙形貌、吸水率和孔隙率,并且将<span style=\"color:red\">丝素</span>与明胶复合可以使支架的热稳定性提高,同时结构更加稳定。","authors":[{"authorName":"殷丽华","id":"d63762b7-89f4-4dcd-9d13-b42d0f844cef","originalAuthorName":"殷丽华"},{"authorName":"彭鹏","id":"f4318026-73f1-40b2-bb3e-177911682fd5","originalAuthorName":"彭鹏"},{"authorName":"牟星","id":"14ccd73f-f9b2-4040-9af2-c0cf4d9c7a9a","originalAuthorName":"牟星"},{"authorName":"程文晓","id":"8d5baba9-8220-4328-b96f-839cfb993529","originalAuthorName":"程文晓"},{"authorName":"黄嵩涛","id":"be269d23-c49f-46e5-9088-941996a17147","originalAuthorName":"黄嵩涛"},{"authorName":"余占海","id":"3a6f4914-07e5-4cdf-b12c-301a860ad331","originalAuthorName":"余占海"}],"doi":"10.3969/j.issn.1001-9731.2013.23.006","fpage":"3388","id":"647a4298-0126-41ee-9728-6135407d994c","issue":"23","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"442c65fe-2606-4a1d-9785-d27472f81a82","keyword":"<span style=\"color:red\">丝素</span>","originalKeyword":"丝素"},{"id":"d58221df-74bc-4786-8ed4-13de72f6bc50","keyword":"明胶","originalKeyword":"明胶"},{"id":"a868e34a-7855-436f-a76c-67c7a45be63a","keyword":"冷冻干燥法","originalKeyword":"冷冻干燥法"},{"id":"28308859-e0b0-4a8d-89a1-07aca7794bb0","keyword":"支架","originalKeyword":"支架"}],"language":"zh","publisherId":"gncl201323006","title":"<span style=\"color:red\">丝素</span>/明胶三维<span style=\"color:red\">多孔</span>支架的构建及其结构和性能表征","volume":"","year":"2013"},{"abstractinfo":"以蚕丝<span style=\"color:red\">丝素</span>蛋白(SF)作为羟基磷灰石(HA)沉积的模板,制备HA/SF复合粉末,用扫描电镜(SEM)、热重分析(TGA)、X射线衍射(XRD)和傅立叶变换红外光谱(FT-IR)对复合粉末进行分析和鉴定.结果表明,合成产物是HA/SF复合物,其平均粒径约为275.7 nm,其中<span style=\"color:red\">丝素</span>蛋白含量为17.8%(质量分数).复合粉末经等静压成型后能够制得弯曲和压缩强度分别为19.87 MPa和28.65 MPa的HA/SF复合<span style=\"color:red\">材料</span>,以NaCl为致孔剂能够制得平均孔径约为61 μm、孔隙率为40%的<span style=\"color:red\">多孔</span>HA/SF复合<span style=\"color:red\">材料</span>.","authors":[{"authorName":"刘佳佳","id":"34cf7c81-e3d4-4503-9cf6-0cff1c04f338","originalAuthorName":"刘佳佳"},{"authorName":"李明忠","id":"6405e759-984d-4e14-9b77-57af2eb7f7bd","originalAuthorName":"李明忠"},{"authorName":"卢神州","id":"235dae9a-d9e6-4310-bece-354062b77d16","originalAuthorName":"卢神州"}],"doi":"","fpage":"245","id":"43c10973-f106-4e56-9ade-fc1dd5a065a2","issue":"5","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"6d919d5e-710a-4beb-987c-a215bd8acf08","keyword":"羟基磷灰石","originalKeyword":"羟基磷灰石"},{"id":"c12ca1e1-8c83-480c-9de9-03b2e67bccda","keyword":"<span style=\"color:red\">丝素</span>蛋白","originalKeyword":"丝素蛋白"},{"id":"0cc9dbe0-51ac-46cf-9f4d-11490e3bfcca","keyword":"<span style=\"color:red\">多孔</span><span style=\"color:red\">材料</span>","originalKeyword":"多孔材料"},{"id":"b8576ec8-9bbb-4ce8-9678-be8f8fd26d6c","keyword":"复合<span style=\"color:red\">材料</span>","originalKeyword":"复合材料"}],"language":"zh","publisherId":"gfzclkxygc200605062","title":"羟基磷灰石/<span style=\"color:red\">丝素</span>蛋白复合<span style=\"color:red\">材料</span>的制备","volume":"22","year":"2006"},{"abstractinfo":"<span style=\"color:red\">丝素</span>蛋白作为来源广泛、性能优良的动物纤维蛋白质,近年来引起了许多研究者的关注.综述了<span style=\"color:red\">丝素</span>蛋白的结构、性质以及作为生物<span style=\"color:red\">材料</span>的应用研究.","authors":[{"authorName":"顾晋伟","id":"b888a8a5-f0ee-443e-94ad-e3ff983716a9","originalAuthorName":"顾晋伟"},{"authorName":"杨新林","id":"4c38804d-8b2b-46b5-9d63-c7c6e8b901c1","originalAuthorName":"杨新林"},{"authorName":"朱鹤孙","id":"7f4908c8-5a2f-48bf-9152-d1f4a695de02","originalAuthorName":"朱鹤孙"}],"doi":"","fpage":"46","id":"4ca77fd6-ab69-44d9-a376-63f378460184","issue":"11","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"e6359165-5b02-4467-9d40-38b277e3f5cf","keyword":"<span style=\"color:red\">丝素</span>蛋白","originalKeyword":"丝素蛋白"},{"id":"8c8068fd-15b9-4ac3-beb9-c705c85ee36b","keyword":"酶固定化<span style=\"color:red\">材料</span>","originalKeyword":"酶固定化材料"},{"id":"b6cf35ad-8084-4855-8b43-d15b35ff30a7","keyword":"医用<span style=\"color:red\">材料</span>","originalKeyword":"医用材料"}],"language":"zh","publisherId":"cldb200111017","title":"<span style=\"color:red\">丝素</span>蛋白作为生物<span style=\"color:red\">材料</span>的研究进展","volume":"15","year":"2001"},{"abstractinfo":"采用冷冻干燥法制备了介孔生物玻璃(M58S)/<span style=\"color:red\">丝素</span>蛋白(SF)复合<span style=\"color:red\">多孔</span>海绵,采用透射电镜(TEM)和场发射扫描电镜(FESEM)等观察M58S和复合<span style=\"color:red\">多孔</span>海绵的形貌和结构特征,通过体外凝血实验、大鼠肝脏止血模型和体外细胞毒性实验评价复合<span style=\"color:red\">多孔</span>海绵的止血性能和细胞毒性.TEM显示M58S内部具有规则的纳米级介孔孔道,排列高度有序,比表面积达400 m2/g,平均孔径为7.3 nm;FESEM显示复合海绵呈现<span style=\"color:red\">多孔</span>沟壑状结构,孔隙率>80%;APTT和PT测试结果表明该复合<span style=\"color:red\">多孔</span>海绵主要通过作用于血液的内源性凝血系统途径促进凝血;小鼠肝脏止血模型显示当M58S含量>15%时,复合<span style=\"color:red\">多孔</span>海绵的止血效果较好且优于明胶海绵,有望用作体外快速止血<span style=\"color:red\">材料</span>.","authors":[{"authorName":"李静静","id":"b1e633bd-2802-45f0-b446-cc8342c7cb11","originalAuthorName":"李静静"},{"authorName":"朱海霖","id":"e81bba78-43a2-4e64-92c8-194c8a0f0853","originalAuthorName":"朱海霖"},{"authorName":"雷彩虹","id":"399c2a86-2301-4e1e-b3d1-f18bf74d3583","originalAuthorName":"雷彩虹"},{"authorName":"陈建勇","id":"ef061f1b-c3d6-4a5b-9606-66035928d72e","originalAuthorName":"陈建勇"}],"doi":"10.3969/j.issn.1001-9731.2017.02.017","fpage":"2096","id":"965e7b8b-ca53-49e9-8a9c-e1fecf2d5403","issue":"2","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"1e777e54-ee4d-45fa-9c9a-4c5da28957a6","keyword":"冷冻干燥","originalKeyword":"冷冻干燥"},{"id":"256fdc19-9677-4a86-97f6-e4f1e63008c2","keyword":"介孔生物玻璃","originalKeyword":"介孔生物玻璃"},{"id":"b70fa2ad-375e-4e16-97d5-3505b59d555a","keyword":"<span style=\"color:red\">丝素</span>蛋白","originalKeyword":"丝素蛋白"},{"id":"38dc424f-683e-4a8a-8028-778ea9255d2b","keyword":"复合<span style=\"color:red\">多孔</span>海绵","originalKeyword":"复合多孔海绵"},{"id":"f141cd17-e17f-4ccd-8741-fd37a424e2a8","keyword":"止血","originalKeyword":"止血"}],"language":"zh","publisherId":"gncl201702017","title":"介孔生物玻璃/<span style=\"color:red\">丝素</span>蛋白复合<span style=\"color:red\">多孔</span>海绵的结构及止血性能研究","volume":"48","year":"2017"}],"totalpage":5783,"totalrecord":57827}