{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"综述了生物活性物质在功能高分子微球上的固定化研究进展,着重阐述共价结合法的最新进展--定向共价结合;功能高分子微球的制备、表征;以及生物活性高分子微球的性质、应用等.","authors":[{"authorName":"闫翠娥","id":"1cf3fa73-c27f-4de0-9944-3551edad2df1","originalAuthorName":"闫翠娥"},{"authorName":"徐章煌","id":"e6bd2e08-3c4b-4117-996a-408c5a64dfb7","originalAuthorName":"徐章煌"},{"authorName":"程时远","id":"78d2af4a-d9cf-4096-9cfc-3b7cb39b7096","originalAuthorName":"程时远"},{"authorName":"封麟先","id":"d8e75336-9c8e-4eb5-a830-a84b21288554","originalAuthorName":"封麟先"}],"doi":"","fpage":"1","id":"c7a8d45b-61f5-4bd7-baf9-be0c44646630","issue":"1","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"d3eaedfe-9fc0-4cfc-a1df-772946b067ba","keyword":"功能高分子微球","originalKeyword":"功能高分子微球"},{"id":"146e86e2-1f3f-4287-a72b-15f39d8ef7c3","keyword":"生物活性物质","originalKeyword":"生物活性物质"},{"id":"6a8a4d0f-1e83-4dd6-b872-79bdab96db81","keyword":"共价固定","originalKeyword":"共价固定"}],"language":"zh","publisherId":"gfzclkxygc199901001","title":"生物活性高分子微球","volume":"","year":"1999"},{"abstractinfo":"采用壳聚糖作为载体,通过分子结构设计,以叶酸靶向受体改性壳聚糖,然后选择5-氟尿嘧啶为模型药物,采用复凝聚法制备新型壳聚糖靶向缓释功能高分子载药微球.通过红外光谱和1H-NMR核磁共振分析确定了叶酸改性壳聚糖化学结构,并通过扫描电镜、激光粒度分析仪、激光共聚焦显微镜及紫外光谱等现代仪器和分析方法对载药微球的形貌结构、粒径、包埋率、载药量和体外药物释放特性等进行研究.结果表明,模型药物被成功包埋到叶酸改性后的壳聚糖微球中,包埋率E和栽药量L最高可达86.5％和32.7％,载药微球的平均粒径为5.251μm,多分散系数(PDI)为0.056,球形度、分散性良好；激光共聚焦显微镜结果显示微球为核壳结构；体外释放实验表明壳聚糖靶向缓释功能高分子载药微球具有持久的缓释作用,24h后载药微球在模拟胃液(pH值=1.2)中释放率为70％,在模拟肠液(pH值=7.4)中释放率为40％,释药速度与释放介质的pH值密切相关.","authors":[{"authorName":"杨子明","id":"44b899cb-ecd9-4f90-a81c-7e19e6629b00","originalAuthorName":"杨子明"},{"authorName":"彭政","id":"8e39f183-86b6-4c6a-a6ff-c7bfa88db0d1","originalAuthorName":"彭政"},{"authorName":"周敏","id":"08e3b6aa-3f36-44e4-9c30-a4e3613bab10","originalAuthorName":"周敏"},{"authorName":"李思东","id":"04ea2d8c-f693-43ac-ab86-ab5acb9ae987","originalAuthorName":"李思东"},{"authorName":"庞玉新","id":"42707ceb-db76-4bf1-a90b-398dc10d5156","originalAuthorName":"庞玉新"},{"authorName":"李虹","id":"670e590a-2fe4-4bd9-8fb0-e1d1d116190c","originalAuthorName":"李虹"},{"authorName":"李普旺","id":"ec9b471a-f3e3-4aa3-babb-424fcc5a9860","originalAuthorName":"李普旺"}],"doi":"10.3969/j.issn.1001-9731.2013.12.007","fpage":"1703","id":"d51c6a5f-83c1-46e2-a3b0-d49df87e9dcb","issue":"12","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"908d5581-d8ed-484e-b6e0-1455f7ee3944","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"48d4b20c-26aa-4e7e-bbc2-7da4ef1dda8f","keyword":"靶向","originalKeyword":"靶向"},{"id":"bbe2825d-42ea-4dca-8d1b-cd1dd5c148ae","keyword":"缓释","originalKeyword":"缓释"},{"id":"52c82da6-838e-4432-bf26-5bc7338e3542","keyword":"载药微球","originalKeyword":"载药微球"},{"id":"0b6997da-5a89-4fb5-afb0-5c6fb0c8d6c3","keyword":"特性","originalKeyword":"特性"}],"language":"zh","publisherId":"gncl201312007","title":"壳聚糖靶向缓释功能高分子载药微球及其特性研究","volume":"44","year":"2013"},{"abstractinfo":"对磁性高分子微球的研究进展进行了综述,介绍了各类微球的制备方法及相关原理.在此基础上,概述了磁性高分子微球在磁性塑料、固定化酶、细胞分离和靶向药物等领域的应用情况,并对磁性高分子微球的未来研究方向进行了展望.","authors":[{"authorName":"胡书春","id":"87bf2f97-1cbb-422e-87d7-c8eaa57ff8e3","originalAuthorName":"胡书春"},{"authorName":"周祚万","id":"64ab31c7-36c5-4070-9bf4-fbb244c3b26e","originalAuthorName":"周祚万"}],"doi":"10.3969/j.issn.1673-2812.2003.04.038","fpage":"616","id":"5d63cd47-8fd4-48dd-92d0-900b271136ff","issue":"4","journal":{"abbrevTitle":"CLKXYGCXB","coverImgSrc":"journal/img/cover/CLKXYGCXB.jpg","id":"13","issnPpub":"1673-2812","publisherId":"CLKXYGCXB","title":"材料科学与工程学报"},"keywords":[{"id":"ff11ab8e-b550-4fef-954d-b194c470519b","keyword":"磁性高分子微球","originalKeyword":"磁性高分子微球"},{"id":"e981c2d8-c760-4ec4-bfd7-d3f0916698c4","keyword":"制备","originalKeyword":"制备"},{"id":"0ea91e1c-b3e8-402e-9b83-a7f2d0e6dda9","keyword":"磁性塑料","originalKeyword":"磁性塑料"},{"id":"153c514d-1300-4a40-8439-25b525e91c5c","keyword":"固定化酶","originalKeyword":"固定化酶"},{"id":"e02a21b5-f4a9-43f1-802a-0d34bc26de13","keyword":"细胞分离","originalKeyword":"细胞分离"},{"id":"91fd7f2b-3c1e-4a95-b46a-597478572a37","keyword":"靶向药物","originalKeyword":"靶向药物"}],"language":"zh","publisherId":"clkxygc200304038","title":"磁性高分子微球研究进展","volume":"21","year":"2003"},{"abstractinfo":"磁性高分子微球是近二十年来研究的一类新型功能材料.拟从生物高分子磁性微球的制备、结构、性能和应用等几个方面综述近年来国内外有关磁性高分子微球的研究状况.","authors":[{"authorName":"侯冬枝","id":"d484a139-c044-46c2-82fd-af0f6a1010ec","originalAuthorName":"侯冬枝"},{"authorName":"谢长生","id":"9f561131-5e12-4a3b-9f9b-68c1358b7b0a","originalAuthorName":"谢长生"}],"doi":"","fpage":"66","id":"676dedca-6740-4266-806d-758c00150d46","issue":"11","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"8d3b51cf-c543-4295-9a3b-cf20dc26375c","keyword":"磁性高分子微球","originalKeyword":"磁性高分子微球"},{"id":"0a2724d8-09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,{"authorName":"杨连生","id":"1cd41e3b-2e9c-4f48-b4c4-3f0b6bbd37ae","originalAuthorName":"杨连生"}],"doi":"","fpage":"464","id":"09627a4e-55e2-4e12-957f-cc795432376d","issue":"5","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"6c8d15f5-0934-46d3-9e10-1b59062500c0","keyword":"磁性","originalKeyword":"磁性"},{"id":"b058c457-e629-4630-98fc-2294b825deba","keyword":"生物高分子微球","originalKeyword":"生物高分子微球"},{"id":"00a2894f-5187-46fe-95fe-6273cc38c1a2","keyword":"应用","originalKeyword":"应用"}],"language":"zh","publisherId":"gncl200005005","title":"磁性生物高分子微球的制备方法和研究进展","volume":"31","year":"2000"},{"abstractinfo":"在超声辐照下,用过氧化氢对聚乙烯醇(PVA)氧化降解,制得纳米尺寸的β-二酮型高分子微球(PVK),红外光谱表征其β-二酮型结构为烯醇式,透射电镜观察到该纳米粒子平均直径为20 nm. 对PVK的共振散射光性质研究发现,pH=3.0时,PVK与蛋白质形成缔合微粒时将导致PVK 380 nm处RLS信号急剧增加,其强度增加值与蛋白质的浓度呈线性关系,据此可以建立一种测定蛋白质的新方法. 测得HSA和γ-G的线性范围分别为0～15.0 ×10-6 g/mL和0.2×10-6～8.5×10-6 g/mL,检出限为1.4×10-9 g/mL和17.5×10-9 g/mL. 本法应用于人血清样品中蛋白质的定量分析,结果满意.","authors":[{"authorName":"周运友","id":"38abae0c-f8f2-4bb5-a4c7-e569586d54b6","originalAuthorName":"周运友"},{"authorName":"佘世科","id":"dde42635-4729-4765-a229-1ac4839b6ff1","originalAuthorName":"佘世科"},{"authorName":"章丽","id":"e9f414c6-2e6a-4c20-b2e5-0597c0784fba","originalAuthorName":"章丽"},{"authorName":"严正权","id":"2c45ce6b-e968-4b4f-ba4b-5289a939e0d8","originalAuthorName":"严正权"},{"authorName":"卢琴","id":"6f8f5467-1d49-4014-a949-e510a91c4ab6","originalAuthorName":"卢琴"},{"authorName":"王伦","id":"c0f0f5a8-18a7-412e-9c4d-e13c4972a777","originalAuthorName":"王伦"}],"doi":"10.3969/j.issn.1000-0518.2004.12.005","fpage":"1225","id":"736e1720-66b6-48e2-a182-d92c06cc7163","issue":"12","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"f62bb97f-7fdd-46ef-9f48-57a31458eda9","keyword":"高分子纳米粒子","originalKeyword":"高分子纳米粒子"},{"id":"fc3a9a02-2ef8-4741-b37e-972c7ca3df7e","keyword":"聚乙烯醇","originalKeyword":"聚乙烯醇"},{"id":"e0ad1647-0377-45cd-aaa4-4f4c8d993fba","keyword":"β-二酮","originalKeyword":"β-二酮"},{"id":"1d1fafde-1a22-435d-af1f-7f31b158f89d","keyword":"蛋白质","originalKeyword":"蛋白质"},{"id":"0c1be3d6-395d-4ad4-944e-eba1fb612acb","keyword":"共振散射光","originalKeyword":"共振散射光"}],"language":"zh","publisherId":"yyhx200412005","title":"功能性β-二酮型高分子纳米微球的制备及其共振散射光性质","volume":"21","year":"2004"}],"totalpage":3352,"totalrecord":33511}