{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"研究了利用二氯胆碱(PC-2Cl)以及十八烷基二甲基氯硅烷(C18)和1,6-己二异氰酸酯(HDI),将仿细胞膜胆碱(PC)基团化学接枝到盖玻片表面的三条新途径,(Ⅰ) PC-2Cl直接与玻璃表面硅羟基反应,(Ⅱ) HDI先与玻璃表面硅羟基反应、水解产生的端氨基再与PC-2Cl反应进行PC接枝,(Ⅲ) C18与玻璃表面硅羟基反应后再进行Ⅱ的处理步骤.通过测定改性表面的动态接触角(DCA)和X射线光电子能谱(XPS)对改性效果进行评价.结果表明,三条途径均成功地实现了PC基团在盖玻片表面接枝改性,其中接枝HDI后再与二氯胆碱反应的途径PC接枝率较高.","authors":[{"authorName":"杨珊","id":"f30f2f87-c915-4270-86e5-2808c7ad7883","originalAuthorName":"杨珊"},{"authorName":"杨占娴","id":"482ec7af-1885-429b-8a88-4fa7ad8d52a9","originalAuthorName":"杨占娴"},{"authorName":"宫永宽","id":"0ddecdfb-2415-4672-918a-3494aabb16ff","originalAuthorName":"宫永宽"}],"doi":"","fpage":"371","id":"10a2c146-9349-4aa3-9b9b-5ec3665b12c1","issue":"5","journal":{"abbrevTitle":"GNCLYQJXB","coverImgSrc":"journal/img/cover/GNCLYQJXB.jpg","id":"34","issnPpub":"1007-4252","publisherId":"GNCLYQJXB","title":"功能材料与器件学报 "},"keywords":[{"id":"50d9bda1-fceb-4027-800f-729afe51355b","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"50fb341b-ac9d-4778-877d-c79050d24b58","keyword":"玻璃","originalKeyword":"玻璃"},{"id":"9ef9cc30-98a4-4d7c-bca7-801b9096fe3c","keyword":"接枝","originalKeyword":"接枝"},{"id":"735b8b92-b726-4e53-8f5a-4b420c2e781c","keyword":"表面改性","originalKeyword":"表面改性"},{"id":"af64da5d-42e8-4dc5-a3e1-a9b7fb35ef6e","keyword":"接触角","originalKeyword":"接触角"},{"id":"3318b5b1-d935-4763-8cd3-337e413435f1","keyword":"XPS","originalKeyword":"XPS"}],"language":"zh","publisherId":"gnclyqjxb201205006","title":"玻璃表面仿细胞膜胆碱基团改性的新途径","volume":"18","year":"2012"},{"abstractinfo":"为了研究胆碱类聚合 物的生物相容性,以偶氮二异丁腈(AIBN)为引发剂,采用自由基聚合制备了系列2-甲基丙烯氧乙基胆碱(MPC)与甲基丙烯酸丁酯(BMA)、甲基丙烯酸异辛酯(EHMA)的共聚物PMB、PMEH.用红外光谱、元素分析、核磁共振等方法对其结构进行了表征并探讨了其在不同溶剂中的溶解性,为该类物质的提纯提供依据;通过溶剂挥发法制备了共聚物薄膜,血小板黏附实验显示,含有MPC的聚合物薄膜比不含MPC的聚合物薄膜有更好的血液相容性;溶胀度测试显示MPC聚合物薄膜有非常好的吸收水的能力,且平衡含水量( EWC)会随着MPC在聚合物薄膜中含量的增加而增加,当MPC在PMB20中的摩尔含量为18%时,平衡含水量可以达到47%,这是胆碱类聚合物薄膜具有优良生物相容性的原因之一.","authors":[{"authorName":"李琳","id":"f45284a8-068f-4ef2-8372-aae22a653300","originalAuthorName":"李琳"},{"authorName":"辛忠","id":"d6dcc825-fa70-4855-ab09-773f35a129de","originalAuthorName":"辛忠"},{"authorName":"王俊华","id":"8846377a-59a7-4581-92a0-33f23c75390f","originalAuthorName":"王俊华"}],"doi":"10.3969/j.issn.1007-8924.2012.01.007","fpage":"40","id":"1892bc6c-7dff-46cc-a433-36b5d28178f2","issue":"1","journal":{"abbrevTitle":"MKXYJS","coverImgSrc":"journal/img/cover/MKXYJS.jpg","id":"54","issnPpub":"1007-8924","publisherId":"MKXYJS","title":"膜科学与技术 "},"keywords":[{"id":"e0539fd7-8cf8-4cd2-aea2-cd14ea67ff4e","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"9cc9fabe-8c8e-4971-88b2-09efd093d9d3","keyword":"血小板黏附","originalKeyword":"血小板黏附"},{"id":"f5eb6979-cee1-4a58-a697-cc139ba4d6e3","keyword":"溶胀度","originalKeyword":"溶胀度"},{"id":"65a731ab-0078-4d46-82dd-0ddf6f1f7e0d","keyword":"生物相容性","originalKeyword":"生物相容性"}],"language":"zh","publisherId":"mkxyjs201201007","title":"胆碱共聚物的合成及膜的生物相容性","volume":"32","year":"2012"},{"abstractinfo":"2-甲基丙烯氧乙基胆碱(MPC)与甲基丙烯酸异辛酯(EHMA)通过自由基聚合制备共聚物PMEH20,并将PMEH20添加到基材聚氨酯中制备了共混膜。牛血清蛋白(BSA)吸附性测试显示当PMEH20质量分数为15%时,BSA吸附量比空白聚氨酯下降了81.7%;血小板粘附性能测试显示,含有PMEH20的聚氨酯共混膜粘附了更少的血小板;动态水接触角测试发现共混膜中胆碱基团可以通过翻转重排于薄膜表面;薄膜力学性能测试显示,在PMEH20质量分数达到10%时,膜材料的综合力学性能最好。","authors":[{"authorName":"李琳","id":"b666d79b-9471-4e9f-8e68-05a7f4e372a4","originalAuthorName":"李琳"},{"authorName":"辛忠","id":"68d3b9c8-c984-4571-88bf-9068a0ab7ed0","originalAuthorName":"辛忠"},{"authorName":"陆馨","id":"311017e5-b884-40b9-93d0-90036947c39c","originalAuthorName":"陆馨"}],"doi":"","fpage":"5","id":"7ae3995f-fa27-42fd-9243-723c7942a5f7","issue":"3","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"54010d04-2e46-4443-98e3-73a0bb966327","keyword":"聚氨酯","originalKeyword":"聚氨酯"},{"id":"a753547b-bb63-4b3e-ab6c-bcb9833b84a8","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"febcf222-1575-4a96-b300-5c62c4bdfd3e","keyword":"生物相容性","originalKeyword":"生物相容性"}],"language":"zh","publisherId":"gfzclkxygc201203002","title":"胆碱共聚物(MPC-co-EHMA)的合成及对聚氨酯膜的生物相容性影响","volume":"28","year":"2012"},{"abstractinfo":"用具有高亲水性和优良生物相容性的磷脂胆碱化合物改性HEMA/NVP,制备新型角膜接触镜水凝胶,并初步探讨其对水凝胶性能的影响.在光引发剂IRGACURE2959作用下,以HEMA和NVP为主要单体,加入一定量的2-甲基丙烯氧乙基-2'-三甲胺乙基磷酸酯·内盐(MPC),紫外光引发自由基聚合制备PHEMA/NVP-MPC水凝胶.得到的水凝胶在红外光谱(FTIR)中呈现了胆碱结构特征吸收峰.当MPC含量由0增加至5%时,平衡含水率由48.32%提高到53.66%,透光率由36.55%提高到98%以上,抗张强度在0.76~0.35MPa之间.采用磷脂胆碱改性HEMA/NVP制得新型水凝胶,平衡含水率和透光率得到显著改善,可能成为角膜接触镜材料的新选择.","authors":[{"authorName":"周晓蓓","id":"4c9c2633-38c7-4eef-b391-4dfb8968a42c","originalAuthorName":"周晓蓓"},{"authorName":"陈元维","id":"80af04bf-3d71-4d80-ae4f-d532890f70a9","originalAuthorName":"陈元维"},{"authorName":"罗娟","id":"b80865fa-d049-4272-82cb-86db873c4be8","originalAuthorName":"罗娟"},{"authorName":"罗祥林","id":"d6d46234-fb77-41a7-b263-c3cda4b92148","originalAuthorName":"罗祥林"}],"doi":"","fpage":"838","id":"7f0c50c4-fabf-4e66-b844-be1ce6281e00","issue":"5","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"a12411c0-b21f-48eb-a87b-288b244271bf","keyword":"甲基丙烯酸-2-羟乙酯","originalKeyword":"甲基丙烯酸-2-羟乙酯"},{"id":"1f7f56e8-938c-418c-a6b7-ba34b143c623","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"a65ebf04-b461-42df-8049-e9e7083d285b","keyword":"N-乙烯基吡咯烷酮","originalKeyword":"N-乙烯基吡咯烷酮"},{"id":"17837749-e762-4fd7-97ac-ef85b83f9155","keyword":"水凝胶","originalKeyword":"水凝胶"}],"language":"zh","publisherId":"gncl200805040","title":"含磷脂胆碱新型水凝胶的制备及性能初探","volume":"39","year":"2008"},{"abstractinfo":"通过表面原子转移自由基聚合法(SI-ATRP)得到具有不同接枝密度的聚2-甲基丙烯氧乙基胆碱改性的聚己内酯薄片(PCL-g-PMPC)。用衰减全反射红外、扫描电镜及接触角直接或间接地证明表面接枝反应成功;并通过蛋白吸附、血小板粘附及凝血时间对其血液相容性进行了评价。结果表明,利用 SI-ATRP 法在PCL表面接枝一层具有仿细胞外层膜结构的PMPC能不同程度地提高PCL薄片的血液相容性。","authors":[{"authorName":"何浏","id":"57a9bae9-5dda-4fbf-885a-e1ddfe677a1d","originalAuthorName":"何浏"},{"authorName":"马宇皓","id":"3fefe6a3-c8dd-4923-b07f-25864fcefcc3","originalAuthorName":"马宇皓"},{"authorName":"黄磊","id":"9d125e6e-c0af-42b7-b89d-76d1b25e696f","originalAuthorName":"黄磊"},{"authorName":"张松柏","id":"01486b7f-658d-439f-945f-0f91171a12dc","originalAuthorName":"张松柏"},{"authorName":"陈元维","id":"762110c3-6c46-4fe9-97c7-f121483f6064","originalAuthorName":"陈元维"},{"authorName":"罗祥林","id":"6516ae63-4df9-4bb0-8ac1-d3d7da339157","originalAuthorName":"罗祥林"}],"doi":"10.3969/j.issn.1001-9731.2016.06.017","fpage":"6098","id":"fe1a45e4-23a7-459c-86eb-d6fc02abe901","issue":"6","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"951423f7-910c-4bfa-b3a0-0468139bcf57","keyword":"聚己内酯","originalKeyword":"聚己内酯"},{"id":"cf3008e0-16e5-493b-a2fa-cc8ce50e2e6a","keyword":"表面原子转移自由基聚合","originalKeyword":"表面原子转移自由基聚合"},{"id":"4f376e9f-f3b1-430c-bf97-19e40d14bf26","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"af52b30f-753b-4d8c-88a5-c4e1d45157be","keyword":"血液相容性","originalKeyword":"血液相容性"}],"language":"zh","publisherId":"gncl201606017","title":"聚已内酯表面磷酸胆碱仿生改性的血液相容性研究?","volume":"47","year":"2016"},{"abstractinfo":"将聚阳离子壳聚糖(CS)与聚阴离子甲基丙烯氧乙基胆碱-甲基丙烯酸二元共聚物(poly (MPC-co-MA ),PMA30)进行静电复合,制备 CS/PMA30聚离子水凝胶,并用红外(IR )、扫描电镜(SEM)分别对其特征官能团、表面形貌进行表征。然后,以中性红为模型药物对CS/PMA30水凝胶的控释性能进行研究。结果表明,CS/PMA30体系是通过静电作用形成的物理交联水凝胶,对模型药物中性红具有明显的控释性和pH 值响应性。该水凝胶具有良好生物相容性有望在药物控释、组织工程等领域具有巨大的应用前景。该研究为进一步提高水凝胶的生物相容性提供了一个新的途径。","authors":[{"authorName":"宫铭","id":"cb68cc11-77e1-4126-98cd-0fe591335237","originalAuthorName":"宫铭"},{"authorName":"宋成建","id":"6b0144b0-3b16-4668-a462-45c8c40f11fe","originalAuthorName":"宋成建"},{"authorName":"曲建林","id":"5ef11229-d5b8-4825-8387-e3a2d9232f64","originalAuthorName":"曲建林"},{"authorName":"汪广恒","id":"70a29e5d-f5cd-4b11-8615-1312446520fe","originalAuthorName":"汪广恒"},{"authorName":"于伟","id":"292549d2-54c8-4b87-b255-90dd9c4b49f1","originalAuthorName":"于伟"},{"authorName":"宫永宽","id":"88a1ac73-e142-4e37-b5cb-0c100947b7ad","originalAuthorName":"宫永宽"}],"doi":"10.3969/j.issn.1001-9731.2015.05.015","fpage":"5075","id":"4ef3c8ef-82e0-47ce-8fab-31aecd3bb337","issue":"5","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"9250b513-b52b-46c8-bc5c-27b4cf295261","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"fd77588f-a13f-4347-841a-e17836e3a64e","keyword":"水凝胶","originalKeyword":"水凝胶"},{"id":"0375e86c-5b4b-48db-a338-410d0c561f42","keyword":"胆碱","originalKeyword":"磷酰胆碱"},{"id":"838f7775-78a9-463d-b881-b083a0a2a4f4","keyword":"控释性能","originalKeyword":"控释性能"}],"language":"zh","publisherId":"gncl201505015","title":"CS/PMA30水凝胶的制备及其对中性红控释性能的研究?","volume":"","year":"2015"},{"abstractinfo":"为提高聚谷氨酸苄酯的亲水性和抗凝血性能,采用紫外光交联法将亲水性和抗凝血性能良好的2-甲基丙烯氧乙基胆碱(MPC)引入端烯丙基-聚谷氨酸苄酯(A-PBLG)原位制备出A-PBLG与MPC的共聚物(PBLG-co-PMPC).研究结果表明,PBLG-co-PMPC中的MPC含量随着照射时间的增加而增加.由于MPC的引入导致PBLG-co-PMPC的亲水性和降解速度都得到明显地提高.血小板粘附实验研究表明,PBLG-co-PMPC比A-PBLG具有更好的抗凝血性能.","authors":[{"authorName":"周秀苗","id":"b7b1898a-e625-49de-9df7-7db9e7fcdec8","originalAuthorName":"周秀苗"},{"authorName":"王迎军","id":"ccf11f98-85a6-4d0e-9cfc-0fa6b19fcbb4","originalAuthorName":"王迎军"},{"authorName":"任力","id":"d93fc487-8241-4714-af7b-fe41a1d78d49","originalAuthorName":"任力"}],"doi":"","fpage":"1904","id":"dca4bd1d-2e90-456d-ae6a-8d5033999fb7","issue":"11","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"fa8dd693-0dd3-4c38-8f6e-68ca30f4b376","keyword":"聚谷氨酸苄酯","originalKeyword":"聚谷氨酸苄酯"},{"id":"bd77a867-819d-4c58-b60f-c0edb1033ff8","keyword":"2-甲基丙烯氧乙基胆碱","originalKeyword":"2-甲基丙烯酰氧乙基磷酰胆碱"},{"id":"69e1efb3-2817-4824-87cb-af3a286135db","keyword":"紫外交联","originalKeyword":"紫外交联"},{"id":"f0ad7f45-d8ce-4bd7-a09c-7396e4dd2e1f","keyword":"亲水性","originalKeyword":"亲水性"},{"id":"f8cce839-6c61-4cc3-ba82-f337cb369d1c","keyword":"抗凝血性","originalKeyword":"抗凝血性"}],"language":"zh","publisherId":"gncl200911040","title":"聚谷氨酸苄酯-co-聚胆碱的制备与性能研究","volume":"40","year":"2009"},{"abstractinfo":"采用Antherton-Todd反应合成了两种胆碱酰化偶联壳聚糖衍生物——带双正电荷的N-二胆碱酰化偶联壳聚糖(N-PC+Cs)和两性的N-磷酸胆碱酰化偶联壳聚糖(N-PCCs),并用核磁共振波谱(NMR)和红外光谱(IR)表征其化学结构。由1H-NMR谱得到N-PC+Cs的取代度为30.9%,N-PCCs的取代度为32.6%。X射线衍射谱(XRD)和热分析的结果表明,与壳聚糖相比,N-PC+Cs和N-PCCs的结晶性和热稳定性都显著降低。水溶性试验表明,两种仿生衍生物在中性水溶液中都表现出良好的溶解性,有望用于药物/基因传输系统载体。","authors":[{"authorName":"王泽虎","id":"50c102d8-3189-47ce-865a-30e020df245f","originalAuthorName":"王泽虎"},{"authorName":"曾戎","id":"4e77568f-936a-4289-bed3-205e775a1a23","originalAuthorName":"曾戎"},{"authorName":"屠美","id":"5559ed71-dd7c-424b-a1c0-fcb457327d05","originalAuthorName":"屠美"},{"authorName":"赵剑豪","id":"c85eec61-0af9-4fdd-ac02-70c3a3257ca3","originalAuthorName":"赵剑豪"}],"doi":"","fpage":"20","id":"be1b56a1-fabb-4ec1-8c16-3812f0bacdb6","issue":"2","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"53ec3510-1b09-4275-9f1d-1d27fa53a8c7","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"93228205-bd8f-4849-9fba-95dc56673d02","keyword":"胆碱","originalKeyword":"胆碱"},{"id":"60d6c117-ada4-49ec-975c-0d4f9fb2a367","keyword":"仿生","originalKeyword":"仿生"},{"id":"3e63e09d-8dd8-4fe9-a3f9-bd762f02ffdc","keyword":"Antherton-Todd反应","originalKeyword":"Antherton-Todd反应"}],"language":"zh","publisherId":"gfzclkxygc201202006","title":"胆碱酰化偶联壳聚糖仿生衍生物的合成及表征","volume":"28","year":"2012"},{"abstractinfo":"通过LB膜仪对表面压力-面积(π-A)曲线测量及原子力显微镜(AFM)观测,研究了胆固醇对磷脂胆碱/神经酰胺二元体系结构的影响.π-A曲线分析表明,随着胆固醇的增加,加速了相变的发生,促进了膜稳定状态的形成;AFM观察结果表明,磷脂胆碱/神经酰胺(PC/CER)二元混合系统单分子膜呈现为小的微区结构,当PC/CER二元混合系统与胆固醇混合时,随着胆固醇比例的增加,混合膜呈现从链状结构向较大的片状与网状共存结构的转化,最终纯胆固醇形成高度紧密的膜结构.","authors":[{"authorName":"刘晓燕","id":"0b997db9-ea82-4eac-9598-47b6959a2d3a","originalAuthorName":"刘晓燕"},{"authorName":"郝长春","id":"45184af0-0381-421f-b5c5-0b1c45fe31ed","originalAuthorName":"郝长春"},{"authorName":"孙润广","id":"b1d10720-8591-4abb-91db-9d38f7b114ac","originalAuthorName":"孙润广"}],"doi":"10.3969/j.issn.1007-2780.2009.06.004","fpage":"794","id":"c459eb22-25f6-440b-bda3-d1009d302b45","issue":"6","journal":{"abbrevTitle":"YJYXS","coverImgSrc":"journal/img/cover/YJYXS.jpg","id":"72","issnPpub":"1007-2780","publisherId":"YJYXS","title":"液晶与显示 "},"keywords":[{"id":"b1b29ec9-c25e-4f10-9532-227193d13af6","keyword":"脂筏","originalKeyword":"脂筏"},{"id":"59dbba36-9a05-4114-a900-610420038ae0","keyword":"LB膜技术","originalKeyword":"LB膜技术"},{"id":"33b9b408-80aa-4b32-83b9-4e9d8a6c8cf9","keyword":"原子力显微镜","originalKeyword":"原子力显微镜"},{"id":"b7f86619-28c5-4824-aaf2-cc3306e71dfc","keyword":"胆固醇","originalKeyword":"胆固醇"}],"language":"zh","publisherId":"yjyxs200906004","title":"胆固醇对磷脂胆碱/神经酰胺二元体系结构的影响","volume":"24","year":"2009"},{"abstractinfo":"采用反相离子对高效液相色谱(RP-IP-HPLC)法分离分析了不同种类的磷脂胆碱(PC),色谱柱为PERKIN-ELMER/HS-5 C18柱,流动相为甲醇-乙腈-水(70∶22∶8,体积比)(内含15 mmol/L四甲基磷酸铵离子对试剂,pH 7),流速2 mL/min,在208 nm波长处检测,该法成功地分离了7种PC.","authors":[{"authorName":"王智华","id":"60c761a0-194f-4608-913f-2101c8e13641","originalAuthorName":"王智华"},{"authorName":"卢学清","id":"4ba8129a-d144-4ad4-9924-a67150877763","originalAuthorName":"卢学清"},{"authorName":"洪筱坤","id":"ed7fe460-a81b-43b2-bdfd-75a01d4ca89f","originalAuthorName":"洪筱坤"}],"doi":"10.3321/j.issn:1000-8713.2002.03.015","fpage":"249","id":"315c666d-35a0-46a6-b2ed-ba60776e44b8","issue":"3","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"3f826d5c-716e-4ccc-87ec-b1cf02294db3","keyword":"反相离子对高效液相色谱","originalKeyword":"反相离子对高效液相色谱"},{"id":"c63b8748-6341-4caa-913e-aa620c251705","keyword":"磷脂胆碱","originalKeyword":"磷脂酰胆碱"},{"id":"38769b98-8a3e-40c6-af35-adcffc7ec486","keyword":"分子种类","originalKeyword":"分子种类"}],"language":"zh","publisherId":"sp200203015","title":"反相离子对高效液相色谱法分离不同种类的磷脂胆碱","volume":"20","year":"2002"}],"totalpage":462,"totalrecord":4611}