{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"以D,L-<span style=\"color:red\">乳酸</span>熔融聚合直接合成的低分子量聚外消旋<span style=\"color:red\">乳酸</span>(PDLLA)为原料,通过二异氰酸酯扩链合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>,用2,4-甲苯二异氰酸酯(TDI)为扩链剂进行扩链的最佳工艺条件为:在SnCl2催化下,NCO/OH=1:1时,160℃下反应60min,分子量增加3.42倍,同时也提高了以<span style=\"color:red\">乳酸</span>为初始原料合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>的利用率.","authors":[{"authorName":"王浚","id":"199a626b-754f-4bf1-a174-c4121da0a4b4","originalAuthorName":"王浚"},{"authorName":"汪朝阳","id":"cb171804-f5b2-4710-8ba3-6596063f9d5b","originalAuthorName":"汪朝阳"},{"authorName":"赵耀明","id":"3f143a0e-8b78-4a7a-a108-ac22e8210234","originalAuthorName":"赵耀明"}],"doi":"10.3969/j.issn.1671-5381.2003.01.002","fpage":"4","id":"00c19e12-ddad-4203-9b63-92429877a54e","issue":"1","journal":{"abbrevTitle":"HCCLLHYYY","coverImgSrc":"journal/img/cover/HCCLLHYYY.jpg","id":"42","issnPpub":"1671-5381","publisherId":"HCCLLHYYY","title":"合成材料老化与应用"},"keywords":[{"id":"4308e3d3-6ef7-48e1-9e55-d78e3c78ab5c","keyword":"2,4-甲苯二异氰酸酯","originalKeyword":"2,4-甲苯二异氰酸酯"},{"id":"5c96ca1d-0f14-42e0-966a-496d1321c61a","keyword":"扩链","originalKeyword":"扩链"},{"id":"e61a82ec-36af-4dac-8492-1db0f1577cae","keyword":"<span style=\"color:red\">聚乳酸</span><span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>","originalKeyword":"聚乳酸药物缓释材料"}],"language":"zh","publisherId":"hccllhyyy200301002","title":"二异氰酸酯扩链合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>的研究","volume":"32","year":"2003"},{"abstractinfo":"以D,L-<span style=\"color:red\">乳酸</span>直接合成的低分子量聚外消旋<span style=\"color:red\">乳酸</span>(PDLLA)为原料,通过二异氰酸酯扩链合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>,采用2,4-甲苯二异氰酸酯(TDI)为扩链剂,反应在四氢呋喃溶液中进行,扩链反应工艺条件为:在SnCl2催化下,NCO/OH摩尔比=1～2:1时,66°C下回流反应1～1.5h,分子量可增加3倍以上.与熔融扩链法相比,进一步提高了以<span style=\"color:red\">乳酸</span>为初始原料合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>的利用率,且反应条件更为温和、易于调控.","authors":[{"authorName":"汪朝阳","id":"591e2654-514a-4bc1-9bc1-912fcfa278fd","originalAuthorName":"汪朝阳"},{"authorName":"王浚","id":"6f79e7c4-4b41-46c4-a2dd-d4c4fa2c626c","originalAuthorName":"王浚"},{"authorName":"赵耀明","id":"b2120f92-640e-4274-ab57-885e67960b0b","originalAuthorName":"赵耀明"},{"authorName":"王方","id":"4045e579-f0d5-4f61-a75d-e2696ebeacdb","originalAuthorName":"王方"},{"authorName":"游革新","id":"6b43bea6-c155-4042-881e-75da16a2860c","originalAuthorName":"游革新"}],"doi":"10.3969/j.issn.1671-5381.2004.01.001","fpage":"1","id":"da318d1b-1d1a-4d0f-b5e2-d07123c4494b","issue":"1","journal":{"abbrevTitle":"HCCLLHYYY","coverImgSrc":"journal/img/cover/HCCLLHYYY.jpg","id":"42","issnPpub":"1671-5381","publisherId":"HCCLLHYYY","title":"合成材料老化与应用"},"keywords":[{"id":"beba171c-3e6e-4283-95ff-b77d6457b99b","keyword":"2,4-甲苯二异氰酸酯","originalKeyword":"2,4-甲苯二异氰酸酯"},{"id":"37047932-196f-4a1e-8245-5f222012dccc","keyword":"溶液扩链","originalKeyword":"溶液扩链"},{"id":"21704523-b72b-4c5d-b8fb-49b270c708d8","keyword":"<span style=\"color:red\">聚乳酸</span><span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>","originalKeyword":"聚乳酸药物缓释材料"}],"language":"zh","publisherId":"hccllhyyy200401001","title":"二异氰酸酯扩链合成<span style=\"color:red\">聚乳酸类药物</span><span style=\"color:red\">缓释</span><span style=\"color:red\">材料</span>的研究Ⅱ.溶液法","volume":"33","year":"2004"},{"abstractinfo":"<span style=\"color:red\">聚乳酸</span>静电纺丝纳米纤维因具有孔隙率小、比表面积大等优点,在组织工程、<span style=\"color:red\">药物</span>控释等领域具有广阔的应用前景.文中综述了<span style=\"color:red\">聚乳酸</span>纳米纤维的制备方法及其结构形貌与性能,并介绍了<span style=\"color:red\">聚乳酸</span>纳米纤维作为<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>体系的载体对<span style=\"color:red\">药物</span>的负载和释放的研究现状,同时对<span style=\"color:red\">聚乳酸</span>纳米纤维在组织工程和生物医药等领域的研究进行了展望.","authors":[{"authorName":"李玉洁","id":"431b139f-514b-47bf-ba98-04e7e1dc51ae","originalAuthorName":"李玉洁"},{"authorName":"姚军燕","id":"2af707d8-826a-4920-b5d9-5a0cc721bdab","originalAuthorName":"姚军燕"},{"authorName":"陈明河","id":"7dcc0572-2e3b-4677-be67-5629e7bed963","originalAuthorName":"陈明河"},{"authorName":"苗旺","id":"5d734ada-f6a1-43cd-b66f-53ef68b4c4fe","originalAuthorName":"苗旺"}],"doi":"","fpage":"147","id":"bb736078-c75d-42f4-855d-1a15edaaef60","issue":"6","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"7bd917ed-c963-4f41-83c0-66e071001520","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"de58ccda-9f69-4908-8a74-7baeedfccf36","keyword":"静电纺丝","originalKeyword":"静电纺丝"},{"id":"70e368e1-c23e-4e4a-becf-855e6871067d","keyword":"<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>","originalKeyword":"药物缓释"},{"id":"c884e817-28b8-4b0c-bdc5-1ab3140a483d","keyword":"纳米纤维","originalKeyword":"纳米纤维"}],"language":"zh","publisherId":"gfzclkxygc201406031","title":"<span style=\"color:red\">聚乳酸</span>静电纺丝纳米纤维及其<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>体系","volume":"30","year":"2014"},{"abstractinfo":"采用熔融聚合法直接合成生物降解<span style=\"color:red\">材料</span><span style=\"color:red\">聚乳酸</span>-乙醇酸(PLGA),并以其为载体制备基因重组人干扰素<span style=\"color:red\">聚乳酸</span>-乙醇酸微球(IFN-α-PLGA-MS).通过正交试验对干扰素微球的制备工艺进行了优选,同时对微球的性质进行了考察.结果以D, L-<span style=\"color:red\">乳酸</span>、乙醇酸为原料,氯化亚锡(SnCl2)为催化剂,在165 ℃、70 Pa下熔融聚合10 h ,PLGA特性粘数[η]最高可达0.2382 dL/g,干扰素微球的形态圆整,平均粒径为10.71 μm,<span style=\"color:red\">药物</span>确已被包裹在微球中,微球载药量和包封率分别为8.06%、36.97%,且获得了较满意的干扰素微球制备工艺.","authors":[{"authorName":"杨帆","id":"7ed169db-8a85-4333-af49-8c042eb50696","originalAuthorName":"杨帆"},{"authorName":"汪朝阳","id":"ccf31bb3-cb1d-40c2-a318-0a8f140d147b","originalAuthorName":"汪朝阳"},{"authorName":"潘育方","id":"7a094a86-03a6-4b2c-b9f3-705df67095f4","originalAuthorName":"潘育方"},{"authorName":"洪慧","id":"d04c9490-bcdb-4609-a05e-10cf438e73c8","originalAuthorName":"洪慧"},{"authorName":"赵耀明","id":"e6eb44c5-75a3-4c0e-ac62-d9bd4710e781","originalAuthorName":"赵耀明"},{"authorName":"徐安龙","id":"dd97c87c-6ee6-4529-b526-166900b9fb76","originalAuthorName":"徐安龙"}],"doi":"","fpage":"77","id":"a39747a3-ff8b-4cf2-8055-1d354f98b3cb","issue":"3","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"9f2d280e-d284-40a5-a7d6-6f5ec8ff8237","keyword":"<span style=\"color:red\">聚乳酸</span>-乙醇酸","originalKeyword":"聚乳酸-乙醇酸"},{"id":"0921b26f-6413-42bb-9246-da5a3c749ed9","keyword":"直接熔融聚合","originalKeyword":"直接熔融聚合"},{"id":"6060b0c3-bd30-4966-bec8-666745550d03","keyword":"制备","originalKeyword":"制备"},{"id":"178214f4-a67c-4c70-968d-b40fac29a874","keyword":"干扰素-α","originalKeyword":"干扰素-α"},{"id":"e9d0bf04-3ee0-487c-8d3a-401336efdcb5","keyword":"微球","originalKeyword":"微球"}],"language":"zh","publisherId":"gfzclkxygc200503018","title":"<span style=\"color:red\">聚乳酸</span>-乙醇酸的合成及在<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>微球中的应用","volume":"21","year":"2005"},{"abstractinfo":"以L-<span style=\"color:red\">聚乳酸</span>为模型体系,超临界CO2为抗溶剂,采用超临界流体抗溶剂法制备<span style=\"color:red\">聚乳酸</span>微球.考察了压力、温度、溶液浓度、溶液流速、二氯甲烷-丙酮混合溶剂、聚合物分子量等参数对制备微球的形态、粒径及其分布的影响.结果表明,改变工艺参数,可在一定范围内调控微球粒径,所制微球平均粒径0.67～6.64μm,溶液浓度及其流速为主要影响因素;实验条件一定时,采用二氯甲烷-丙酮混合溶剂及强制分散溶液法制备得较小粒径微球.释放度实验结果表明,微球按一级释放方程释药,具<span style=\"color:red\">缓释</span>效果.","authors":[{"authorName":"蒲曦鸣","id":"34d6b359-a0c5-4126-ab32-deb821269404","originalAuthorName":"蒲曦鸣"},{"authorName":"康云清","id":"c01edcff-1794-4d2f-ae2e-c164d424004b","originalAuthorName":"康云清"},{"authorName":"陈爱政","id":"6d6b529b-eff6-479a-8554-30d28c67cc6e","originalAuthorName":"陈爱政"},{"authorName":"尹光福","id":"ad5c8ff4-e13d-473b-aa97-2d88f0f47832","originalAuthorName":"尹光福"},{"authorName":"廖立","id":"d9321160-153f-4f6e-85ff-5b065b006d58","originalAuthorName":"廖立"},{"authorName":"陈琳","id":"ff77f43a-c972-4466-ab21-dd4ec6eb3bf5","originalAuthorName":"陈琳"}],"doi":"","fpage":"549","id":"8a412659-a830-403b-a849-ec88b2d24c7a","issue":"4","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"fa95b9f1-d659-46c6-a6c1-05ff06c1bf16","keyword":"超临界二氧化碳","originalKeyword":"超临界二氧化碳"},{"id":"eb037d66-1905-4a2f-b669-126a886f7bd9","keyword":"抗溶剂法","originalKeyword":"抗溶剂法"},{"id":"167530a5-1814-428e-84a4-0e639b7833ff","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"b505b051-68e7-4305-9758-2a5e1410a98b","keyword":"微球","originalKeyword":"微球"}],"language":"zh","publisherId":"gncl200704011","title":"超临界CO2抗溶剂法制备<span style=\"color:red\">聚乳酸</span><span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>微球","volume":"38","year":"2007"},{"abstractinfo":"综述了用<span style=\"color:red\">聚乳酸</span>类可生物降解型高分子<span style=\"color:red\">材料</span>制备缓控释<span style=\"color:red\">药物</span>载体的研究现状.分别介绍了该类<span style=\"color:red\">材料</span>在微粒给药载体、凝胶制剂、<span style=\"color:red\">缓释</span>支架和埋植制剂的应用及其制备方法.阐述了目前<span style=\"color:red\">聚乳酸</span>类生物降解<span style=\"color:red\">材料</span>在缓控释<span style=\"color:red\">药物</span>制剂中的主要问题,展望了其发展前景.","authors":[{"authorName":"梁兆丰","id":"47aa04f3-1edc-4a9c-bb61-b97185bc89da","originalAuthorName":"梁兆丰"},{"authorName":"温玉琴","id":"d5ff127b-3f4f-46cf-b926-4d2d8fcb25ff","originalAuthorName":"温玉琴"},{"authorName":"孙美丽","id":"997f77e6-d322-4e29-b6a6-a16dfcdcc577","originalAuthorName":"孙美丽"},{"authorName":"吕竹芬","id":"4ec8b968-16f0-4188-b815-c3b1435da9d2","originalAuthorName":"吕竹芬"}],"doi":"","fpage":"70","id":"83f1ab58-3cca-4bad-9775-371811ff8cd8","issue":"19","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"9f943515-d75c-4ffb-9ee1-3f77f994b20d","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"3c337ef2-b1e0-450f-a704-73ea61014ecc","keyword":"缓控释制剂","originalKeyword":"缓控释制剂"},{"id":"7976da5c-de45-4172-9e1b-c24795337eda","keyword":"<span style=\"color:red\">药物</span>载体","originalKeyword":"药物载体"},{"id":"07fb56e1-91dc-48b2-9243-59960dec44c4","keyword":"生物可降解<span style=\"color:red\">材料</span>","originalKeyword":"生物可降解材料"}],"language":"zh","publisherId":"cldb201319015","title":"<span style=\"color:red\">聚乳酸</span>类可生物降解<span style=\"color:red\">材料</span>在缓控释<span style=\"color:red\">药物</span>制剂中的应用","volume":"27","year":"2013"},{"abstractinfo":"以DL-<span style=\"color:red\">乳酸</span>为原料,通过熔融聚合法直接合成外消旋<span style=\"color:red\">聚乳酸</span>(PDLLA).以SnCl2为催化剂,用量0.5%(质量),在170 ℃、70 Pa下反应10 h,获得了粘均分子量为4100的PDLLA,将其应用于红霉素肺靶向微球的载体.用正交试验确定了红霉素-<span style=\"color:red\">聚乳酸</span>微球(ERY-PDLLA-MS)最佳成型工艺条件,用DSC和SEM表征其成球性能.微球体外<span style=\"color:red\">缓释</span>半衰期为28 h,175 h后累积释药百分率约为80%.注射微球混悬剂的兔肺组织中<span style=\"color:red\">药物</span>含量为普通市售红霉素注射剂的6倍,达到了肺靶向的目的.","authors":[{"authorName":"赵耀明","id":"9405ced0-7a83-431e-8520-ae0eaf42eab4","originalAuthorName":"赵耀明"},{"authorName":"汪朝阳","id":"81613ceb-a97e-4f63-aeb2-780a8ee56a4f","originalAuthorName":"汪朝阳"},{"authorName":"麦杭珍","id":"f0118732-6acb-4db2-8f76-ce2e3af223f0","originalAuthorName":"麦杭珍"},{"authorName":"严冰","id":"af978ad9-9b33-484b-b8ef-c03cd9968735","originalAuthorName":"严冰"},{"authorName":"杨帆","id":"573ccef6-76f8-47b3-baa3-444c70edb07c","originalAuthorName":"杨帆"}],"doi":"","fpage":"145","id":"438d36da-b71f-40a8-bd46-8fecff62b43f","issue":"5","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"cc15b839-2f0c-42c2-bd4b-31b65cb20563","keyword":"DL-<span style=\"color:red\">乳酸</span>","originalKeyword":"DL-乳酸"},{"id":"da4db55c-dd86-4fe9-8d0f-fe9caa27e505","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"ef25ee44-4a32-46c2-b647-3e0f7df402ac","keyword":"熔融聚合","originalKeyword":"熔融聚合"},{"id":"bf2dfb30-3090-4847-8ba8-e1a0f831d301","keyword":"微球","originalKeyword":"微球"},{"id":"c612ed3b-1c19-4466-af33-41491d8bcf30","keyword":"红霉素","originalKeyword":"红霉素"},{"id":"2e7aaeae-9c7f-4111-a60e-88a202b2a46b","keyword":"肺靶向","originalKeyword":"肺靶向"}],"language":"zh","publisherId":"gfzclkxygc200305038","title":"<span style=\"color:red\">聚乳酸</span>的直接合成及其红霉素肺靶向<span style=\"color:red\">药物</span>微球的应用","volume":"19","year":"2003"},{"abstractinfo":"研究试图通过本体改性,将生物素接枝到聚乙二醇接枝<span style=\"color:red\">聚乳酸</span>(PPLA)上,以改善<span style=\"color:red\">聚乳酸</span>微球在<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>应用中血液循环时间短和无主动靶向性的缺点.在本实验室制备的聚乙二醇接枝改性<span style=\"color:red\">聚乳酸</span>的基础之上,采用N-羟基琥珀酰亚胺活化酯法,将生物素接枝到PPLA上,制备生物素改性<span style=\"color:red\">聚乳酸</span>(BPLA),通过茚三酮显色、核磁共振(1H-NMR),差示扫描量热(DSC),静态水接触角、荧光蛋白标记法对<span style=\"color:red\">材料</span>进行表征与检测.结果表明,生物素已经共价接枝到<span style=\"color:red\">聚乳酸</span>上;与PPLA相比,BPLA明显降低了对牛血清白蛋白(BSA)的吸附,有望提高<span style=\"color:red\">聚乳酸</span>微球在血液循环系统中的停留时间;同时能与生物素的配体亲和素结合,有望通过生物素和亲和素的高亲和性实现主动靶向,可能使BPLA在<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>中有潜在应用价值.","authors":[{"authorName":"严好","id":"9540f8e7-f659-4762-a210-70e64116605c","originalAuthorName":"严好"},{"authorName":"潘君","id":"79e6699e-2741-424e-b065-eff7408e2a1a","originalAuthorName":"潘君"},{"authorName":"江伟民","id":"773f94ed-7c04-48a2-aab0-7424207b5c8a","originalAuthorName":"江伟民"},{"authorName":"张晓喜","id":"fb371fc5-d9b8-4848-af0d-0702c44ae54b","originalAuthorName":"张晓喜"},{"authorName":"王远亮","id":"ddd78c51-4944-4ce4-a212-eae80d6f496f","originalAuthorName":"王远亮"}],"doi":"","fpage":"399","id":"188cca7e-7dd6-402d-a1ed-ffcb965b17cd","issue":"3","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"6a54cd59-4dc1-4d76-9efa-3c0f829570ab","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"a6847d32-c82f-4bf4-9dcd-033624e65b68","keyword":"生物素","originalKeyword":"生物素"},{"id":"374ee9d0-13fd-4e6c-9484-7d0cbc544c9b","keyword":"亲和素","originalKeyword":"亲和素"},{"id":"2bb994c6-3f01-4ede-9a95-153583552339","keyword":"生物活性","originalKeyword":"生物活性"},{"id":"5d0987a7-d47f-459d-b17a-15557687026e","keyword":"<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>","originalKeyword":"药物缓释"}],"language":"zh","publisherId":"gncl201103005","title":"一种生物素改性<span style=\"color:red\">聚乳酸</span>生物<span style=\"color:red\">材料</span>的制备与性能研究","volume":"42","year":"2011"},{"abstractinfo":"<span style=\"color:red\">聚乳酸</span>具有良好的生物降解性、生物相容性和生物可吸收性,研究其在水中的降解行为对于指导<span style=\"color:red\">聚乳酸</span>的改性,满足不同的实际需要有非常重要的意义.本文对<span style=\"color:red\">聚乳酸</span>类降解<span style=\"color:red\">材料</span>的水解机理、影响水解的因素进行了综述.","authors":[{"authorName":"刘磊","id":"5146b18b-a5ad-4753-8b59-8b177d4c092a","originalAuthorName":"刘磊"},{"authorName":"吴若峰","id":"16484495-e6c3-4a60-ac7c-46c40d607f2f","originalAuthorName":"吴若峰"}],"doi":"10.3969/j.issn.1671-5381.2006.01.012","fpage":"44","id":"ad00ec29-c421-4488-bfea-aba17ae212db","issue":"1","journal":{"abbrevTitle":"HCCLLHYYY","coverImgSrc":"journal/img/cover/HCCLLHYYY.jpg","id":"42","issnPpub":"1671-5381","publisherId":"HCCLLHYYY","title":"合成材料老化与应用"},"keywords":[{"id":"95f9f090-5770-440a-bfc1-a7526a63a13c","keyword":"<span style=\"color:red\">聚乳酸</span>","originalKeyword":"聚乳酸"},{"id":"0f5eddfa-f7ec-4903-a452-98333c320942","keyword":"水解","originalKeyword":"水解"},{"id":"43b3fd2c-4bae-4cec-a8e5-851b45715823","keyword":"机理","originalKeyword":"机理"}],"language":"zh","publisherId":"hccllhyyy200601012","title":"<span style=\"color:red\">聚乳酸</span>类<span style=\"color:red\">材料</span>的水解特性","volume":"35","year":"2006"},{"abstractinfo":"采用向孔隙中灌注含<span style=\"color:red\">聚乳酸</span>-聚乙醇酸共聚物(PLGA)载药微球的明胶溶液的方法制备了具有<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>功能的明胶/磷酸钙骨水泥复合组织工程支架.用扫描电子显微镜观察了微球和支架的形貌特征,用万能<span style=\"color:red\">材料</span>试验机测定了支架<span style=\"color:red\">材料</span>的抗压强度,用紫外-可见分光光度计分析了复合支架的释药率.结果表明,灌注明胶对多孔磷酸钙骨水泥支架起到显著的增强作用,抗压强度达2.42MPa.复合支架携载硫酸庆大霉素,具有良好的<span style=\"color:red\">药物</span><span style=\"color:red\">缓释</span>功能,<span style=\"color:red\">缓释</span>时间可达30天以上,使支架在修复骨缺损的同时能消除炎症反应,成为一种集骨修复和治疗于一体的新型组织工程支架<span style=\"color:red\">材料</span>,具有良好的应用前景.","authors":[{"authorName":"谭红香","id":"217bec58-6e77-4a01-afd2-002d18215e15","originalAuthorName":"谭红香"},{"authorName":"叶建东","id":"14755620-74d3-4d56-ba2d-b873f80753a2","originalAuthorName":"叶建东"},{"authorName":"董浩","id":"5db95ed3-e031-4dc1-b661-4f96ec98a036","originalAuthorName":"董浩"}],"doi":"","fpage":"77","id":"d93f770e-4b1c-41d4-9ac4-0737025055e7","issue":"6","journal":{"abbrevTitle":"FHCLXB","coverImgSrc":"journal/img/cover/FHCLXB.jpg","id":"26","issnPpub":"1000-3851","publisherId":"FHCLXB","title":"复合材料学报"},"keywords":[{"id":"f125ba7c-2279-4fbc-ad83-6a4f126e6d64","keyword":"磷酸钙骨水泥","originalKeyword":"磷酸钙骨水泥"},{"id":"1f2ec12e-7719-404f-b730-b7fdbed60ce5","keyword":"支架","originalKeyword":"支架"},{"id":"6616a23d-15ae-4522-a3e3-bb3d6b38629d","keyword":"PLGA微球","originalKeyword":"PLGA微球"},{"id":"bb105c61-e241-43b0-bbdf-b0a7f8127c96","keyword":"硫酸庆大霉素","originalKeyword":"硫酸庆大霉素"},{"id":"255f7842-86fc-4bdd-a610-fd5440c265a7","keyword":"明胶","originalKeyword":"明胶"}],"language":"zh","publisherId":"fhclxb200806015","title":"可<span style=\"color:red\">缓释</span><span style=\"color:red\">药物</span>的明胶/磷酸钙骨水泥复合组织工程支架<span style=\"color:red\">材料</span>","volume":"25","year":"2008"}],"totalpage":5653,"totalrecord":56528}