相分离技术是近年来制备组织工程支架的一项新技术.研究了溶剂、溶液浓度、降温速率对多孔材料微孔结构的影响,确定了获得微米-纳米尺度微结构的参数.通过试验探索出了用高凝固点溶剂低温快速冷冻制备PLGA纳米结构的方法,讨论了溶剂影响微米-纳米多孔结构的因素.通过选取适当的溶剂、冷冻温度和溶液浓度,可以控制获得的多孔结构的尺寸,制备更适合细胞黏附、增殖的组织工程支架.
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