邻苯二甲酰化的二肽(1)在光照下,经过单电子转移形成分子内双自由基(5),自由基(5)分子内耦合成环得到含哌嗪酮的化合物.此反应产率较好,可以成为合成哌嗪酮类化合物的新方法.所有新化合物均经NMR和MS确定其结构.
Biradical(5) were formed by photoinduced single electron transfer of N-phthalimido dipeptide(1) under irradiation. The biradical(5) could couple intramolecularly to form cycloproduct(2) containing ketonpiprazine moiety. This good yield reaction could be used as a new synthesis method for ketonpiperazine analogous. The structures of all the new compounds were characterized by MS and NMR spectra.
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