综述了SiO2基药物可控释放材料,分析了简单、掺杂、杂化SiO2药物可控释放凝胶,以及介孔SiO2药物可控释放材料的特点,讨论了水和前驱物的比例、催化剂、掺杂剂、凝胶前驱物的种类、凝胶比表面积与孔径、凝胶尺寸及药物负载量、以及药物与凝胶基质及掺杂剂之间的相互作用对可控释放的影响.对于SiO2基药物可控释放材料来说,基质溶胀和基质溶解对药物可控释放的影响不大,药物扩散是释放的主要机制.基于介孔SiO2的pH敏感和光敏开关效应,为SiO2基药物可控释放材料提供了新思路.
参考文献
| [1] | Wu ZJ;Joo H;Lee TG;Lee K .Controlled release of lidocaine hydrochloride from the surfactant-doped hybrid xerogels[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(3):497-505. |
| [2] | Kortesuo P;Ahola M;Kangas M;Yli-Urpo A;Kiesvaara J;Marvola M .In vitro release of dexmedetomidine from silica xerogel monoliths: effect of sol-gel synthesis parameters.[J].International Journal of Pharmaceutics,2001(1/2):107-114. |
| [3] | Ahola MS;Sailynoja ES;Raitavuo MH;Vaahtio MM;Salonen JI;Yli-Urpo AU .In vitro release of heparin from silica xerogels.[J].Biomaterials,2001(15):2163-2170. |
| [4] | Ahola M;Kortesuo P;Kangasniemi I;Kiesvaara J;Yli Urpo-A .Silica xerogel carrier material for controlled release of toremifene citrate.[J].International Journal of Pharmaceutics,2000(1/2):219-227. |
| [5] | Wu ZJ;Joo H;Ahn IS;Kim JH;Kim CK;Lee K .Design of doped hybrid xerogels for a controlled release of brilliant blue FCF[J].Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites,2004(1/3):46-53. |
| [6] | Ahola M;Kortesuo P;Kangasniemi I;Kiesvaara J;Yli Urpo-A .Silica xerogel carrier material for controlled release of toremifene citrate.[J].International Journal of Pharmaceutics,2000(1/2):219-227. |
| [7] | Kortesuo P;Ahola M;Kangas M et al.Alkyl-subsituted silica gel as a carrier in the controlled release of dexmedetomidine[J].Journal of Controlled Release,2001,76:227. |
| [8] | Vallet-Regi M;Doadrio JC;Doadrio AL;Izquierdo-Barba I;Perez-Pariente J .Hexagonal ordered mesoporous material as a matrix for the controlled release of amoxicillin[J].Solid state ionics,2004(1/4):435-439. |
| [9] | Charnay C;Begu S;Tourne Peteilh C;Nicole L;Lerner DA;Devoisselle JM .Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2004(3):533-540. |
| [10] | Horcajada P;Ramila A;Perez-Pariente J et al.Influence of pore size of MCM-41 matrices on drug delivery rate[J].Microporous and Mesoporous Materials,2004,68:105. |
| [11] | Doadrio AL;Sousa EMB;Doadrio JC;Pariente JP;Izquierdo-Barba I;Vallet-Regi M .Mesoporous SBA-15 HPLC evaluation for controlled gentamicin drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(1):125-132. |
| [12] | 张永青,王琴,钟炳.溶胶-凝胶法制备超细SiO2--制备参数对气凝胶织构性质的影响[J].燃料化学学报,1996(06):517-521. |
| [13] | da Costa JCD.;Lu GQ.;Rudolph V.;Lin YS. .Novel molecular sieve silica (MSS) membranes: characterisation and permeation of single-step and two-step sol-gel membranes[J].Journal of Membrane Science,2002(1):9-21. |
| [14] | Atkin R.;Craig VSJ.;Wanless EJ.;Biggs S. .Mechanism of cationic surfactant adsorption at the solid-aqueous interface [Review][J].Advances in Colloid and Interface Science,2003(3):219-304. |
| [15] | Wu ZJ.;Lee K.;Lin YX.;Lan XR.;Huang LY. .Effects of surface-active substances on acid-base indicator reactivity in SiO2 gels[J].Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites,2003(1/3):168-176. |
| [16] | Wu Z;Joo H;Ahn I S et al.Organic dye adsorption on mesoporous hybrid gels[J].Chemical Engineering Journal,2004,102:277. |
| [17] | Wu ZJ;Ahn IS;Lee CH;Kim JH;Shul YG;Lee KT .Enhancing the organic dye adsorption on porous xerogels[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2004(1/3):157-164. |
| [18] | Siepmann J;Peppas N A .Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC)[J].Advanced Drug Delivery Reviews,2001,48:139. |
| [19] | Rao M S;Gray J;Dave B C .Smart glasses:Molecular programming of dynamic responses in organosilica sol-gels[J].Journal of Sol-Gel Science and Technology,2003,26:553. |
| [20] | Brinker C J;Scherer G W.Sol-gel science:The Physics and Chemistry of Sol-Gel Processing[M].Academic Press,1990:373. |
| [21] | Iler R K.The Chemistry of Silica[M].Wiley-Interscience Publication,1979:62. |
| [22] | Falaize S;Radin S;Ducheyne P .In vitro behavior of silicabased xerogels intended as controlled release carriers[J].Journal of the American Ceramic Society,1999,82:969. |
| [23] | 李艳,褚良银,朱家骅,曾刚,夏素兰,陈文梅.环境感应式控制释放开关膜的研究进展[J].高分子材料科学与工程,2003(05):37-41. |
| [24] | 宋江莉,王秀芬.LCST类水凝胶开关效应的研究进展[J].化学进展,2004(01):56-60. |
| [25] | Mal N K;Fujiwara M;Tanaka Y .Photocontrolled reversible release of guest molecules from coumarinmodified mesoporous silica[J].Nature,2003,421:350. |
| [26] | Casasus R;Marcos M D;Martinez-Manez R et al.Toward the development of ionically controlled nanoscopic molecular gates[J].Journal of the American Chemical Society,2004,126:8612. |
| [27] | 王德平,黄文显,陈天丹.多孔微晶玻璃作为药物载体材料的制备及其体外释药研究[J].无机材料学报,2001(06):1195-1198. |
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