合成了两亲性嵌段共聚物聚己内酯(ε-己内酯)-b-聚甲基丙烯酸二乙胺基乙酯和聚乙二醇-二硫键-聚己内酯,用核磁氢谱和凝胶渗透色谱对聚合物的结构及分子量进行了表征.用溶剂挥发法制备了聚合物胶束,用动态光散射以及扫描电镜对胶束结构及性质进行了表征.结果显示,两种聚合物自身可以形成胶束,也可以形成混合胶束；形成的混合胶束粒径在pH小于5.5或pH大于6.5时基本保持稳定,且前者稍大于后者,而在10mmol/L的二硫苏糖醇(DTT)的还原条件下,胶束发生破坏并产生团聚,体现了混合胶束的pH敏感性和还原敏感性,期望能够作为新的药物载体.
参考文献
| [1] | Wu, Z.;Zeng, X.;Zhang, Y.;Feliu, N.;Lundberg, P.;Fadeel, B.;Malkoch, M.;Nystr?m, A.M. .Linear-dendritic polymeric amphiphiles as carriers of doxorubicin-In vitro evaluation of biocompatibility and drug delivery[J].Journal of Polymer Science, Part A. Polymer Chemistry,2012(2):217-226. |
| [2] | Fleige,E.;Quadir,M.A.;Haag,R. .Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications[J].Advanced drug delivery reviews,2012(9):866-884. |
| [3] | Amalina Bte Ebrahim Attia;Zhan Yuin Ong;James L Hedrick .Mixed micelles self-assembled from block copolymers for drug delivery[J].Current opinion in colloid & interface science,2011(3):182-194. |
| [4] | Ren, T.-B.;Feng, Y.;Zhang, Z.-H.;Li, L.;Li, Y.-Y. .Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS- poly(ethyl glycol) copolymer for intracellular drug release[J].Soft matter,2011(6):2329-2331. |
| [5] | Zhang, J.;Wu, L.;Meng, F.;Wang, Z.;Deng, C.;Liu, H.;Zhong, Z. .PH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery[J].Langmuir: The ACS Journal of Surfaces and Colloids,2012(4):2056-2065. |
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