磁性纳米Fe3O4颗粒(MNP-Fe3O4)作为药物载体在肿瘤治疗领域受到广泛关注.综述了目前MNP-Fe3O1的研究现状,重点阐述了该材料的表面改性目的与改性途径,介绍了MNP-Fe3O4不同载药系统在肿瘤治疗中的应用,并详细阐述了介孔结构的MNP-Fe3O4颗粒作为药物载体的优势,指出了MNP-Fe3O1在肿瘤治疗中仍需解决的问题和发展趋势.
参考文献
| [1] | 彭健,刘桦,邬力祥.纳米磁靶向药物载体在肝癌治疗中的研究进展[J].中国现代医学杂志,2008(01):80-83. |
| [2] | Jinhao Gao;Bing Xu .Applications of nanomaterials inside cells[J].Nano Today,2009(1):37-51. |
| [3] | Polyak B;Friedman G .Magnetic targeting for site-specific drug delivery: applications and clinical potential.[J].Expert opinion on drug delivery,2009(1):53-70. |
| [4] | Veiseh O;Gunn JW;Zhang M .Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.[J].Advanced drug delivery reviews,2010(3):284-304. |
| [5] | 陈汝福,陈积圣.纳米技术在肿瘤诊断与治疗中的应用[J].癌症,2004(12):1714-1716. |
| [6] | 侯仰龙.磁性纳米材料的化学合成、功能化及其生物医学应用[J].大学化学,2010(02):1-11. |
| [7] | McCarthy JR;Weissleder R .Multifunctional magnetic nanoparticles for targeted imaging and therapy.[J].Advanced drug delivery reviews,2008(11):1241-1251. |
| [8] | Kim K Y .Nanotechnology platforms and physiological challenges for cancer therapeutics[J].Nanomedicine,2007,3(02):103. |
| [9] | Zhou, H.;Tao, K.;Ding, J.;Zhang, Z.;Sun, K.;Shi, W. .A general approach for providing nanoparticles water-dispersibility by grinding with poly (ethylene glycol)[J].Colloids and Surfaces, A. Physicochemical and Engineering Aspects,2011(1/3):18-26. |
| [10] | Dufort,S.;Sancey,L.;Coll,J.-L. .Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution[J].Advanced drug delivery reviews,2012(2):179-189. |
| [11] | Cole AJ;David AE;Wang J;Galban CJ;Yang VC .Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles.[J].Biomaterials,2011(26):6291-6301. |
| [12] | Gang Cheng;Hong Xue;Zheng Zhang .A Switchable Biocompatible Polymer Surface with Self-Sterilizing and Nonfouling Capabilities[J].Angewandte Chemie,2008(46):8831-8834. |
| [13] | Rui Xu;Guoying Sun;Qiuyu Li;Enbo Wang;Jianmin Gu .A dual-responsive superparamagnetic Fe_3O_4/Silica/PAH/PSS material used for controlled release of chemotherapeutic agent, keggin polyoxotungstate, PM-19[J].Solid state sciences,2010(10):1720-1725. |
| [14] | 李瑞歌,李鼎,朱春山.β-环糊精/丁二酸酐共聚高分子磁性微球的制备及其体外释药性能研究[J].辽宁化工,2011(06):543-546. |
| [15] | 谭亮,张阳德.温度敏感性脂质体磁性阿霉素纳米粒的制备[J].中国现代医学杂志,2010(05):656-658. |
| [16] | 阚思行,王晓文,唐劲天,岳炳飞.纳米药物控释系统研究进展[J].解放军药学学报,2009(02):169-171. |
| [17] | Wang Liang;Neoh Koon Gee;Kang En Tang et al.Multifunctional polyglycerol-grafted Fe3O4@SiO2 nanoparticles for targeting ovarian cancer cells[J].Biomaterials,2011,32(08):2166. |
| [18] | 王中领,郭亮,李勇刚,陈铟铟,顾宏伟,鲁英杰.叶酸靶向超顺磁性氧化铁-多巴胺-叶酸纳米复合物的制备及体外MR成像[J].中国医学影像技术,2011(02):251-255. |
| [19] | Guo M;Que C;Wang C;Liu X;Yan H;Liu K .Multifunctional superparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery.[J].Biomaterials,2011(1):185-194. |
| [20] | Ying, X.-Y.;Du, Y.-Z.;Hong, L.-H.;Yuan, H.;Hu, F.-Q. .Magnetic lipid nanoparticles loading doxorubicin for intracellular delivery: Preparation and characteristics[J].Journal of Magnetism and Magnetic Materials,2011(8):1088-1093. |
| [21] | 朱荣,罗奎,徐翔晖,吴尧,何斌,顾忠伟.以磁纳米粒为核的pH敏感型聚谷氨酸树状分子药物载体[J].高分子学报,2011(06):679-686. |
| [22] | 杨萍,王晶,景红梅,克晓燕.柔红霉素联合磁性纳米铁对Raji细胞株的作用研究[J].中国实验血液学杂志,2011(02):385-389. |
| [23] | Zhang Gen;Lai Binbin;Zhou Yanyan et al.Fe3O4 nanoparticles with daunorubicin induce apoptosis through caspase 8PARP pathway and inhibit K562 leukemia cell-induced tumor growth in vivo[J].Nanomedicine,2011,7(05):595. |
| [24] | Ling Y;Wei K;Luo Y;Gao X;Zhong S .Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy.[J].Biomaterials,2011(29):7139-7150. |
| [25] | 闫润民,梁超,赵明,张嘉靖,易林华,傅相平,常津,李安民.磁性紫杉醇-四氧化三铁-载药脂质体复合体微粒磁靶向脑内分布的实验研究[J].生物医学工程与临床,2011(02):103-106,封2. |
| [26] | Cheng L;Zhou X J .Anti-tumor mechanisms of plant alkaloids[J].Chinese Traditional and Herbal Drugs,2004,35(02):216. |
| [27] | Zhu A;Yuan L;Jin W .Polysaccharide surface modified Fe3O4 nanoparticles for camptothecin loading and release.[J].Acta biomaterialia,2009(5):1489-1498. |
| [28] | Akira Taguchi;Ferdi Schuth .Ordered mesoporous materials in catalysis[J].Microporous and Mesoporous Materials,2005(1):1-45. |
| [29] | Slowing II;Vivero-Escoto JL;Wu CW;Lin VS .Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers.[J].Advanced drug delivery reviews,2008(11):1278-1288. |
| [30] | Lingyun Chen;Zhen Lin;Chenglan Zhao .Direct synthesis and characterization of mesoporous Fe_3O_4 through pyrolysis of ferric nitrate-ethylene glycol gel[J].Journal of Alloys and Compounds: An Interdisciplinary Journal of Materials Science and Solid-state Chemistry and Physics,2011(1):L1-L5. |
| [31] | Mitra Atanu;Vázquez-Vázquez Carlos;Arturo López-Quintela M et al.Soft-templating approach for the synthesis of high surface area and superparamagnetic mesoporous iron oxide materials[J].Microporous and Mesoporous Materials,2010,131(1-3):373. |
| [32] | Zhou Weijia;He Wen;Zhong Shide et al.Biosynthesis and magnetic properties of mesoporous Fe3O4 compo-sites[J].Journal of Magnetism and Magnetic Materials,2009,321(08):1025. |
| [33] | Yunsheng Xia;Hongxing Dai;Haiyan Jiang;Lei Zhang;Jiguang Deng;Yuxi Liu .Three-dimensionally ordered and wormhole-like mesoporous iron oxide catalysts highly active for the oxidation of acetone and methanol[J].Journal of hazardous materials,2011(1):84-91. |
| [34] | Guo S;Li D;Zhang L;Li J;Wang E .Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery.[J].Biomaterials,2009(10):1881-1889. |
| [35] | Bin Luo;Shuai Xu;Wan-Fu Ma .Fabrication of magnetite hollow porous nanocrystal shells as a drug carrier for paclitaxel[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2010(34):7107-7113. |
| [36] | 伊希斌,沈晓冬,崔升,孙惠敏,李永梅.多孔朵状Fe3O4纳米微球的制备及其性能研究[J].无机化学学报,2010(11):2097-2100. |
| [37] | Huang,C.;Tang,Z.;Zhou,Y.;Zhou,X.;Jin,Y.;Li,D.;Yang,Y.;Zhou,S. .Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy[J].International Journal of Pharmaceutics,2012(1/2):113-122. |
| [38] | Kulshrestha, P.;Gogoi, M.;Bahadur, D.;Banerjee, R..In vitro application of paclitaxel loaded magnetoliposomes for combined chemotherapy and hyperthermia[J].Colloids and Surfaces, B. Biointerfaces,2012:1-7. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%