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作为芯片实验室的典型代表技术,微流控技术发展迅速,目前已经成为一门涵盖了从分离分析、分子生物学研究到生物医学诊断的交叉学科.本文综合阐述了近年来国内外微流控芯片的发展状况,在此基础上对其未来发展趋势进行展望.

参考文献

[1] Shang F;Guihen E;Glennon JD .Recent advances in miniaturisation--the role of microchip electrophoresis in clinical analysis.[J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2012(1):105-116.
[2] Nickolaj Jacob Petersen;Sunniva Taule Foss;Henrik Jensen;Steen Honore Hansen;Christian Skonberg;Detlef Snakenborg;Jorg P. Kutter;Stig Pedersen Bjergaard .On-Chip Electro Membrane Extraction with Online Ultraviolet and Mass Spectrometric Detection[J].Analytical chemistry,2011(1):44-51.
[3] Younan Xia;George M.Whitesides .Soft lithography[J].Annual review of materials research,1998(0):153-184.
[4] Kupka RK.;Cremers C.;Megtert S.;Bouamrane F. .Microfabrication: LIGA-X and applications[J].Applied Surface Science: A Journal Devoted to the Properties of Interfaces in Relation to the Synthesis and Behaviour of Materials,2000(0):97-110.
[5] Changchun Liu .Rapid fabrication of microfluidic chip with three-dimensional structures using natural lotus leaf template[J].Microfluidics and nanofluidics,2010(4/5):923-931.
[6] Xunjun He;Bo Liu;Zhiqiu Lv;Zhihong Li .A lateral RF MEMS capacitive switch utilizing parylene as dielectric[J].Microsystem technologies,2012(1):77-85.
[7] Robert M. Panas;Michael A. Cullinan;Martin L. Culpepper .Design of piezoresistive-based MEMS sensor systems for precision microsystems[J].Precision Engineering,2012(1):44-54.
[8] Bong-Seok Kim;Joon-Shik Park;Byoung Hun Kang;Chanwoo Moon .Fabrication and property analysis of a MEMS micro-gripper for robotic micro-manipulation[J].Robotics and Computer Integrated Manufacturing: An International Journal of Manufacturing and Product and Process Development,2012(1):50-56.
[9] Karuwan, C.;Sukthang, K.;Wisitsoraat, A.;Phokharatkul, D.;Patthanasettakul, V.;Wechsatol, W.;Tuantranont, A. .Electrochemical detection on electrowetting-on-dielectric digital microfluidic chip[J].Talanta: The International Journal of Pure and Applied Analytical Chemistry,2011(5):1384-1389.
[10] Jun Kameoka;Harold G. Craighead;Hongwei Zhang;Jack Henion .A Polymeric Microfluidic Chip for CE/MS Determination of Small Molecules[J].Analytical chemistry,2001(9):1935-1941.
[11] Guan,Q.;Noblitt,S.D.;Henry,C.S. .Electrophoretic separations in poly(dimethylsiloxane) microchips using a mixture of ionic and zwitterionic surfactants[J].Electrophoresis: The Official Journal of the International Electrophoresis Society,2012(2):379-387.
[12] Stefan Nagl;Philipp Schulze;Stefan Ohla;Reinhild Beyreiss;Leonid Gitlin;Detlev Belder .Microfluidic chips for chirality exploration[J].Analytical chemistry,2011(9):3232-3238.
[13] Herbert Ryan;Suk-Heung Song;Anja Zass;Jan Korvink;Marcel Utz .Contactless NMR Spectroscopy on a Chip[J].Analytical chemistry,2012(8):3696-3702.
[14] Windbergs, M.;Weitz, D.A. .Drug Dissolution Chip (DDC): A microfluidic approach for drug release[J].Small,2011(21):3011-3015.
[15] Sifeng Mao;Dan Gao;Wu Liu .Imitation of drug metabolism In human liver and cytotoxicity assay using a mlcroiuidic device coupled to mass spectrometric detection[J].Lab on a chip,2012(1):219-226.
[16] Tianxi He;Qionglin Liang;Kai Zhang ? Xuan Mu;Tingting Luo;Yiming Wang;Guoan Luo .A modified microfluidic chip for fabrication of paclitaxel-loaded poly(L-lactic acid) microspheres[J].Microfluidics and nanofluidics,2011(6):1289-1298.
[17] Huang, WC;Hu, SH;Liu, KH;Chen, SY;Liu, DM .A flexible drug delivery chip for the magnetically-control led release of anti-epileptic drugs[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2009(3):221-228.
[18] Odijk, M.;Baumann, A.;Olthuis, W.;van den Berg, A.;Karst, U. .Electrochemistry-on-chip for on-line conversions in drug metabolism studies[J].Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices,2010(4):1521-1527.
[19] John T.Santini;Robert Langer;Jr.;Michael J.Cima;Any C.Richards;Rebecca Scheidt .Microchips as Controlled Drug-Delivery Devices[J].Angewandte Chemie International Edition,2000(12):2396-2407.
[20] Xu, Y.;Jang, K.;Yamashita, T.;Tanaka, Y.;Mawatari, K.;Kitamori, T. .Microchip-based cellular biochemical systems for practical applications and fundamental research: From microfluidics to nanofluidics[J].Analytical and bioanalytical chemistry,2012(1):99-107.
[21] Yan Du;Chaogui Chen;Ming Zhou;Shaojun Dong;Erkang Wang .Microfluidic Electrochemical Aptameric Assay Integrated On-Chip: A Potentially Convenient Sensing Platform for the Amplified and Multiplex Analysis of Small Molecules[J].Analytical chemistry,2011(5):1523-1529.
[22] Weijie Wan;John T. W. Yeow .Study of a novel cell lysis method with titanium dioxide for Lab-on-a-Chip devices[J].Biomedical microdevices,2011(3):527-532.
[23] Dan Gao;Huibin Wei;Guang-Sheng Guo;Jin-Ming Lin .Microfluidic Cell Culture and Metabolism Detection with Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometer[J].Analytical chemistry,2010(13):5679-5685.
[24] 孙惠芹,刘志兰,李新,刘南平,李峰.基于微流控芯片的单细胞图像观测系统的设计[J].传感技术学报,2008(12):1977-1980.
[25] 何鹏 .微流控芯片单细胞分析[D].青岛科技大学,2009.
[26] Zong-Bin Liu;Yu Zhang;Jin-Jiang Yu;Arthur Fuk-Tat Mak;Yi Li;Mo Yang .A microfluidic chip with poly(ethylene glycol) hydrogel microarray on nanoporous alumina membrane for cell patterning and drug testing[J].Sensors and Actuators, B. Chemical,2010(2):776-783.
[27] Vila-Planas, J.;Fernández-Rosas, E.;Ibarlucea, B.;Demming, S.;Nogués, C.;Plaza, J.A.;Domínguez, C.;Büttgenbach, S.;Llobera, A. .Cell analysis using a multiple internal reflection photonic lab-on-a-chip[J].Nature protocols erecipes for researchers,2011(10):1642-1655.
[28] Ranjana Sahai;Chiara Martino;Piero Castrataro;Arianna Menciassi;Aldo Ferrari;Fabio Beltram;Marco Cecchini .Microfluidic chip with temporal and spatial concentration generation capabilities for biological applications[J].Microelectronic engineering,2011(8):1689-1692.
[29] 李丽潇 .微流控芯片细胞培养和药物诱导凋亡的研究[D].东北大学,2008.
[30] Qiushui Chen;Jing Wu;Yandong Zhang;Jin-Ming Lin .Qualitative and Quantitative Analysis of Tumor Cell Metabolism via Stable Isotope Labeling Assisted Microfluidic Chip Electrospray Ionization Mass Spectrometry[J].Analytical chemistry,2012(3):1695-1701.
[31] Gervais, L.;Hitzbleck, M.;Delamarche, E. .Capillary-driven multiparametric microfluidic chips for one-step immunoassays[J].Biosensors & Bioelectronics: The International Journal for the Professional Involved with Research, Technology and Applications of Biosensers and Related Devices,2011(1):64-70.
[32] Sung Hwan Choi;Dong Sung Kim;Tai Hun Kwon .Microinjection molded disposable microfluidic lab-on-a-chip for efficient detection of agglutination[J].Microsystem technologies,2009(2):309-316.
[33] Victoria Skelton;Gillian M.Greenway;Stephen J.Haswell;Peter Styring;David O.Morgan;Brian H.Warrington;Stephanie Y.F.Wong .The generation of concentration gradients using electroosmotic flow in micro reactors allowing stereoselective chemical synthesis[J].The Analyst: The Analytical Journal of the Royal Society of Chemistry: A Monthly International Publication Dealing with All Branches of Analytical Chemistry,2001(1):11-13.
[34] Qiao, L.;He, F.;Wang, C.;Cheng, Y.;Sugioka, K.;Midorikawa, K. .A microfluidic chip integrated with a microoptical lens fabricated by femtosecond laser micromachining[J].Applied physics, A. Materials science & processing,2011(1):179-183.
[35] CHONG H. AHN;JIN-WOO CHOI;GREGORY BEAUCAGE;JOSEPH H. NEVIN;JEONG-BONG LEE;ANIRUDDHA PUNTAMBEKAR;JAE Y. LEE .Disposable Smart Lab on a Chip for Point-of-Care Clinical Diagnostics[J].Proceedings of the IEEE,2004(1):154-173.
[36] Gascoyne P;Satayavivad J;Ruchirawat M .Microfluidic approaches to malaria detection.[J].Acta tropica,2004(3):357-369.
[37] S.J. Trietsch;T. Hankemeier;H.J. van der Linden .Lab-on-a-chip technologies for massive parallel data generation in the life sciences: A review[J].Chemometrics and Intelligent Laboratory Systems,2011(1):64-75.
[38] Y. C. Lim;A. Z. Kouzani;W. Duan .Lab-on-a-chip: a component view[J].Microsystem technologies,2010(12):1995-2015.
[39] 刘晓为,张海峰,王蔚,田丽,王喜莲.芯片实验室技术及其应用[J].测试技术学报,2006(06):471-479.
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