树状大分子作为药物载体的研究新进展

材料导报, 2008, 22(4): 100-103.

树状大分子作为药物载体的研究新进展

唐杨 ^1, , 马丽芳 ^2, , 郭丽 ^3, , 贺世超 ^4, , 游小杰 ^5,

1.四川大学化学工程学院,成都,610065

2.四川大学化学工程学院,成都,610065

3.四川大学华西药学院,成都,610041

4.四川大学化学工程学院,成都,610065

5.四川大学化学工程学院,成都,610065

基金项目: 国家自然科学基金(20472055)

关键词：树状大分子 , 药物载体 , 增溶 , 缓释 , 靶向

Progress in Study on Dendrimers as Drug-carriers

树状大分子作为药物载体是目前分子药剂学研究的热点.综述了树状大分子作为药物载体发展的几个阶段、载药方式,以及其作为药物裁体在增溶、缓释、靶向等方面的应用,展望了树状大分子作为药物载体的发展趋势.

参考文献

[1]	Jevprasesphant R;Penny J;Jalal R;Attwood D;McKeown NB;D'Emanuele A .The influence of surface modification on the cytotoxicity of PAMAM dendrimers.[J].International Journal of Pharmaceutics,2003(1/2):263-266.
[2]	Kojima C;Kono K;Maruyama K et al.Synthesis of polyami doamine dendrimers having poly(ethylene glycol)grafts and their ability to encapsulate anficancer drugs[J].Bioconjugate Chemistry,2000,11:910.
[3]	Bhadra D;Bhadra S;Jain S;Jain NK .A PEGylated dendritic nanoparticulate carrier of fluorouracil.[J].International Journal of Pharmaceutics,2003(1/2):111-124.
[4]	David Attwood .Dendrimer-drug interactions[J].Advanced Drug Delivery Reviews,2005,57:2147.
[5]	Pavel Kubát;Kamil Lang.Interaction of porphyrins with PAMAM dendrimers in aqueous solution[J].Journal of Molecular Liquids,2007(131-132):200.
[6]	Kolhe P;Misra E;Kannan RM;Kannan S;Lieh Lai M .Drug complexation, in vitro release and cellular entry of dendrimers and hyperbranched polymers.[J].International Journal of Pharmaceutics,2003(1/2):143-160.
[7]	Patri AK;Kukowska Latallo JF;Baker JR Jr .Targeted drug delivery with dendrimers: comparison of the release kinetics of covalently conjugated drug and non-covalent drug inclusion complex.[J].Advanced drug delivery reviews,2005(15):2203-2214.
[8]	Yang H;Lopina S T .Penicillin V-conjugated PEGPAMAM star polymers[J].Journal of Biomaterials Science:Polymer Edition,2003,14:1043.
[9]	Milhem OM;Myles C;McKeown NB;Attwood D;D'Emanuele A .Polyamidoamine Starburst dendrimers as solubility enhancers.[J].International Journal of Pharmaceutics,2000(1/2):239-241.
[10]	Chauhan AS.;Sridevi S.;Chalasani KB.;Jain AK.;Jain SK.;Jain NK. Diwan PV. .Dendrimer-mediated transdermal delivery: enhanced bioavailability of indomethacin[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(3):335-343.
[11]	Ooya T.;Lee J.;Park K. .Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(2):121-127.
[12]	Chen Yiyun;Qu Haiou;Ma Minglu et al.Polyamidoamine (PAMAM)dendrimers as biocompatible carriers of quinolone antimicrobials:An in vitro study[J].European Journal of Medicinal Chemistry,2007,42:1032.
[13]	Ma M;Cheng Y;Xu Z;Xu P;Qu H;Fang Y;Xu T;Wen L .Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug.[J].European Journal of Medicinal Chemistry: Chimie Therapeutique,2007(1):93-98.
[14]	Liu MJ.;Frechet JMJ.;Kono K. .Water-soluble dendritic unimolecular micelles: Their potential as drug delivery agents[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2000(1/2):121-131.
[15]	Yang H;Lopina S T .Extended realsea of a novel antidepressant,venlafaxine,based on anionic polyamidoamine dendrimers and poly(ethylene glycol)-containing semi-inter penetrating network[J].Biomedical Materials Research,2005,72A:107.
[16]	Tathagata Dutta;Arendra;Jainbiochimica K et al.Targeting potential and anti-HIV activity of lamivudine loaded marmosylated poly(propyleneimine)dendrimer[J].Biochimica Et Biophysica Acta,2007,1770:681.
[17]	Wiwattanapatapee R.;Lomlim L.;Saramunee K. .Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2003(1):1-9.
[18]	Patri A K;Thoma T;Baker J R et al.Biological applicationa ofdendrimer[J].Polymeric Materials Science and Engineering,2002,86:130.
[19]	Tatsuya Okuda et al.PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice[J].Journal of Controlled Release,2006,116:330.
[20]	Mohamma Najlah;Sally Freeman .In vitro evaluation of dendrimer prodrugs for oral drug delivery[J].International Journal of Pharmaceutics,2007,336:183.
[21]	Delong R;Stephenson K et al.Poltster dendritic systems for drug delivery applications:design,synthesis,and characterization[J].Journal of Pharmaceutical Sciences,1997,86(06):762.

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材料期刊网

树状大分子作为药物载体的研究新进展

Progress in Study on Dendrimers as Drug-carriers

参考文献