通过甲基丙烯酸(MAA)的原位自由基交联聚合反应制备了一系列新型pH敏感的聚甲基丙烯酸/羧基化多壁碳纳米管(PMAA/MWCNT-COOH)杂合水凝胶.利用红外光谱分析仪(FT-IR)、环境扫描电镜(ESEM)、动态粘弹谱仪(MDA)等对杂合水凝胶的结构、形态和力学性能进行表征.结果表明,MWCNT-COOH的引入,使杂合水凝胶的溶胀速率明显高于纯PMAA水凝胶；在溶胀状态下的力学性能测试表明,水凝胶弹性、回复性能等达到了软组织材料的要求.掺杂不同含量的碳纳米管和改变不同pH环境会影响永凝胶的溶胀行为,改变网孔密度和孔径大小,决定在载、释药物过程中起到重要作用.以茶碱为模拟药物对凝胶载、释药物的研究发现,茶碱在肠道环境中释放速率较快,约8h就达到平衡；而在胃部环境中释放较慢,达到平衡需要时间较长.因此,PMAA/MWCNT-COOH杂合水凝胶有望成为一种潜在的控制药物释放型生物医学材料.
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