乙二胺改性聚(DL-乳酸)(EMPLA)是实验室合成的一种含有丰富氨基和羧基、具良好亲水性且降解产物不呈酸性的生物材料.研究以二环己基碳二亚胺(DCC)为缩合剂,将Ⅰ型胶原共价引入到EMPLA中,制得了新型胶原改性聚乳酸(CPLA)仿生材料,探索并建立了一套向EMPLA基质中共价引入Ⅰ型胶原的液相合成技术.采用异硫氰酸荧光素(FITC)标记技术对CPLA的结构及胶原含量进行了定性表征.结果表明,采用本研究所建立的液相反应技术能将Ⅰ型胶原共价引入到EMPLA中,且CPLA中的胶原含量随EMPLA中乙二胺接枝率(EDA%)的增大而增大.
参考文献
| [1] | Hutmacher D W .[J].J Biomater Sci:Polymer Edn,2001,12(01):107-124. |
| [2] | Middleton JC.;Tipton AJ. .Synthetic biodegradable polymers as orthopedic devices[J].Biomaterials,2000(23 Special Issue SI):2335-2346. |
| [3] | 俞耀庭;张兴栋.生物医用材料[M].天津:天津大学出版社,2000:220-222. |
| [4] | Horbett T A;Schway M .[J].Journal of Biomedical Materials Research,1988,22:763-793. |
| [5] | Pettit D K;Hoffman A S;Horbett T A .[J].J Biomed Mater Sci,1994,28:685-691. |
| [6] | Chinn J;Horbeet T;Ratner B et al.[J].Journal of Colloid and Interface Science,1989,127:67-87. |
| [7] | DiMilla P A;Stone J A;Quinn J A .[J].Journal of Cell Biology,1993,122:729-737. |
| [8] | Calof A L;Lander A D .[J].Journal of Cell Biology,1991,115(03):779-794. |
| [9] | Zheng J S;Nothrup R;Hornsby P J .[J].In Vitro Cell Dev Biolanimal,1998,34:679-684. |
| [10] | Drumheller P D;Hubbell J A .[J].Analytical Chemistry,1994,222:380-388. |
| [11] | Drumheller P D;Ebert D L;Hubbell J A .[J].Biotechnology and Bioengineering,1994,43:772-780. |
| [12] | Tramada Y;Ikada Y .[J].Journal of Biomedical Materials Research,1994,28:783-789. |
| [13] | Massia S P;Hubbell J A .[J].Journal of Biomedical Materials Research,1991,25:223-242. |
| [14] | Brandly B;Schnaar R .[J].Analytical Biochemistry,1988,172:270-278. |
| [15] | Matsuda T;Kondo A;Makino K et al.[J].Transactions of the American Society for Artificial Internal Organs,1989,35:677-679. |
| [16] | Barrera D A;Zylstra E;Lansbury P T et al.[J].Journal of the American Chemical Society,1993,115:11010-11011. |
| [17] | Yan Feng Luo;Yuan Liang Wang;Xu Feng Niu;Jun Pan;Liang Ping Shi .Synthesis and characterization of a novel biomaterial:maleic anhydride-modified poly(dl-lactic acid)[J].Chinese Chemical Letters,2004(5):521-524. |
| [18] | 罗彦凤,王远亮,牛旭锋,吴杨兰,潘君,石梁萍.二胺改性聚乳酸的合成与表征[J].高分子材料科学与工程,2005(02):139-142,146. |
| [19] | Xu Feng NIU;Yuan Liang WANG;Yan Feng LUO;Jun PAN;Juan Fang SHANG;Li Xia GUO .Synthesis of the Biomimetic Polymer:Aliphatic Diamine and RGDS Modified Poly(d,l-lactic acid)[J].Chinese Chemical Letters,2005(8):1035-1038. |
| [20] | 罗彦凤,王远亮,牛旭锋,吴杨兰,潘君,石梁萍.新型改性聚乳酸及其体外生物可降解性研究[J].高技术通讯,2005(02):55-59. |
| [21] | Zhu Y B;Gao C Y;Liu X Y et al.[J].Tissue Engineering,2004,10(1-2):53-61. |
| [22] | 黄惟德;陈常庆.多肽合成[M].北京:科学出版社,1985:102-104. |
| [23] | [OL].http://www.37c.com.cn/literature/library/theory/102/1020302.html |
| [24] | Brenda K M;Annabel T T;Tmothy S B et al.[J].Biomaterials,1999,20:2281-2286. |
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