采用乙酸酐对琼脂糖进行疏水性改性,合成了具有生物活性的琼脂糖醋酸酯.通过红外光谱(FT-IR)、13C核磁共振(13C-NMR)、原子力显微镜和接触角仪对琼脂糖醋酸酯进行了表征.结果表明,琼脂糖C6上引入了乙酰基,随取代度增大,琼脂糖醋酸酯膜表面粗糙度增大,疏水性增强.纺成丝后在水中不溶胀,形态保持完好,吸湿率最小可达52.5%.随取代度的提高,白蛋白的吸附量升高,并有促进细胞粘附和增殖的功能.表明疏水改性琼脂糖可望作为新型组织再生支架材料.
参考文献
| [1] | Shunqing Tang;Wei Yang;Xuan Mao .Agarose/collagen composite scaffold as an anti-adhesive sheet[J].Biomedical materials,2007(3):S129-S134. |
| [2] | Huang, J.-Y.;Bao, L.;Mao, X.;Tang, S.-Q. .Synthesis of agarose-graft-hyaluronan copolymer and its potential application as a peptide carrier[J].Journal of Applied Polymer Science,2010(6):3568-3574. |
| [3] | 戴小敏,左秀锦,刘袖洞,谢威扬,马小军.醋酸酯淀粉高取代度的测定[J].应用化学,2003(07):687-689. |
| [4] | Kumar V;Yang T .Analysis of carboxyl content in oxidized celluloses by solid-state 13C CP/MAS NMR spectroscopy.[J].International Journal of Pharmaceutics,1999(2):219-226. |
| [5] | Keely CM.;Mcbrierty VJ.;Zhang XQ. .HYDRATION AND PLASTICIZATION EFFECTS IN CELLULOSE ACETATE - A SOLID-STATE NMR STUDY[J].Journal of Molecular Structure,1995(1):33-46. |
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