{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"基于从头计算方法和半经验势分子动力学,通过计算<span style=\"color:red\">尿嘧啶</span>分子及其水合<span style=\"color:red\">尿嘧啶</span>分子运动轨迹的速度自关联函数的傅立叶变换,给出了这些分子的振动频率.通过求解Hessian矩阵,鉴别出这些分子每一个振动频率的振动模式.对孤立的<span style=\"color:red\">尿嘧啶</span>分子,计算结果能够和实验数据符合.对水合<span style=\"color:red\">尿嘧啶</span>分子中,<span style=\"color:red\">尿嘧啶</span>分子的结构和振动频率的改变做了讨论.","authors":[{"authorName":"王志萍","id":"f5e1ce1b-7a8e-41ec-89ee-0cb9f32536a0","originalAuthorName":"王志萍"},{"authorName":"张丰收","id":"02daed84-ccdd-4009-a577-9a5cf73b778b","originalAuthorName":"张丰收"},{"authorName":"周宏余","id":"90352b48-c08f-4c0b-ba5e-415f8bd0ffea","originalAuthorName":"周宏余"},{"authorName":"曾祥华","id":"76773f4e-bd60-459e-9650-7f65991e876a","originalAuthorName":"曾祥华"},{"authorName":"顾斌","id":"351b38be-20a6-4ef6-9082-16ae18df9558","originalAuthorName":"顾斌"},{"authorName":"张伟","id":"a16232f1-0010-4ddf-944d-38d283bcbba2","originalAuthorName":"张伟"},{"authorName":"程伟","id":"2c660b74-b877-42c7-ad94-f8e11c16424e","originalAuthorName":"程伟"}],"doi":"10.3969/j.issn.1007-4627.2005.04.032","fpage":"438","id":"07d43941-7501-4420-a17b-86fc96c6d6a4","issue":"4","journal":{"abbrevTitle":"YZHWLPL","coverImgSrc":"journal/img/cover/YZHWLPL.jpg","id":"78","issnPpub":"1007-4627","publisherId":"YZHWLPL","title":"原子核物理评论   "},"keywords":[{"id":"611f085d-2a68-4d39-9861-6eb462fc029f","keyword":"<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"尿嘧啶"},{"id":"122c6a7b-a432-4963-afea-87766290e865","keyword":"水合<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"水合尿嘧啶"},{"id":"152acd4b-9d35-4e32-9c0d-9e9a09995376","keyword":"结构","originalKeyword":"结构"},{"id":"121303b6-93eb-49dd-9715-41abe670800d","keyword":"振动","originalKeyword":"振动"},{"id":"9a2b40ed-b820-4fa3-9dc3-1c505c3418c2","keyword":"半经验分子动力学","originalKeyword":"半经验分子动力学"}],"language":"zh","publisherId":"yzhwlpl200504032","title":"<span style=\"color:red\">尿嘧啶</span>、水合<span style=\"color:red\">尿嘧啶</span>的结构和振动性质研究","volume":"22","year":"2005"},{"abstractinfo":"采用乳液-化学交联法制备磁性氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球,重铬酸钾法测定磁性微球中铁含量,古埃磁天平测定磁性微球的磁化率,用SEM测试技术观察了微球的形态;考察了磁性氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球在磷酸盐缓冲溶液中的释药性能. 结果表明,磁性氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球具有强顺磁性,粒径分布1～10 μm,Fe3O4质量分数为4.55%～11.44%,药物质量分数为1.86%～9.42%,药物包封率为39.48%～85.30%. 体外药物释放实验表明,对氟<span style=\"color:red\">尿嘧啶</span>的缓释作用明显,释放周期比较长,Fe3O4粒子和含量对微球的释药速率影响不明显;药物释放主要受扩散机制控制,药物含量越大,药物从微球中释放出来的速率越快,可作为理想的磁靶向药物控释体系.","authors":[{"authorName":"何强芳","id":"391fb066-5a2f-41f3-9c3c-6c7754e2eb1b","originalAuthorName":"何强芳"},{"authorName":"李国明","id":"5166efa9-9ad9-4ee1-96ab-3f3dfb9b9645","originalAuthorName":"李国明"},{"authorName":"朱洁民","id":"7f6bbad8-c814-4093-8089-2ca665132c8c","originalAuthorName":"朱洁民"}],"doi":"10.3969/j.issn.1000-0518.2006.02.021","fpage":"207","id":"c6b79df4-ef60-4f36-b45b-05359c1a665a","issue":"2","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"040aeaac-9164-4eb2-b1cc-322249c63e38","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"d8b5eeed-17dc-4505-b3c9-0ef3db1c2dde","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"ae40d5d1-d6f0-4443-9cc6-5b4e7f69fdc3","keyword":"磁性微球","originalKeyword":"磁性微球"},{"id":"32ed9f25-958a-4ed1-8a9b-6e92f440a541","keyword":"缓释","originalKeyword":"缓释"}],"language":"zh","publisherId":"yyhx200602021","title":"磁性氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球的制备及其释药性能","volume":"23","year":"2006"},{"abstractinfo":"合成了一种5-氟<span style=\"color:red\">尿嘧啶</span>修饰的自由卟啉（5-[2-（5-氟<span style=\"color:red\">尿嘧啶</span>-3-基）乙氧基苯基]-10，15，20-三（4-甲氧基苯基）卟啉）及其2种金属卟啉配合物：5-[2-（5-氟<span style=\"color:red\">尿嘧啶</span>-3-基）乙氧基苯基]-10，15，20-三（4-甲氧基苯基）锰卟啉和5-[2-（5-氟<span style=\"color:red\">尿嘧啶</span>-3-基）乙氧基苯基]-10，15，20-三（4-甲氧基苯基）锌卟啉。通过紫外可见光谱（UV-Vis）、红外光谱（IR）和核磁共振谱氢谱（1 H NMR）对目标化合物进行了结构表征。用噻唑蓝法（MTT法）测定了自由卟啉、锰卟啉及锌卟啉分别对肺腺癌细胞株A549、肝癌细胞株Bel7402和人结肠癌细胞株HCT-8的抑制活性。其中，锰卟啉对人结肠癌细胞株HCT-8的半抑制浓度为IC50为17.8 mg／L，具有一定的细胞毒作用。","authors":[{"authorName":"任丽磊","id":"75c306e0-178c-4c13-a931-d1dc8a9f13ed","originalAuthorName":"任丽磊"},{"authorName":"彭晓霞","id":"31415cb5-f9cd-4149-a4e4-7fec3d352f15","originalAuthorName":"彭晓霞"},{"authorName":"赵秀丽","id":"31acc285-9d02-4645-b80c-a43099eb4ba3","originalAuthorName":"赵秀丽"},{"authorName":"祝红梅","id":"7f921523-ab5e-402d-8f96-f4f7987d45ba","originalAuthorName":"祝红梅"}],"doi":"10.11944/j.issn.1000-0518.2016.12.160054","fpage":"1415","id":"f3d97c6b-a7fe-46be-90c0-70360fb1947a","issue":"12","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"c496bee8-2067-46ed-a410-e270a51fc4aa","keyword":"卟啉","originalKeyword":"卟啉"},{"id":"b46e0962-c46b-4b73-a1ed-00ad4bd155df","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"5a3d7d96-6e3d-4305-bf09-c8458e065c61","keyword":"抗肿瘤活性","originalKeyword":"抗肿瘤活性"}],"language":"zh","publisherId":"yyhx201612010","title":"5-氟<span style=\"color:red\">尿嘧啶</span>修饰卟啉的合成及抗肿瘤活性","volume":"33","year":"2016"},{"abstractinfo":"以壳聚糖为载体,戊二醛为交联剂,以span-80和硬脂酸镁为复合乳化剂,真空泵油和石蜡油相混合为油相,通过乳液-化学交联法制备了5-氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球,所得微球的药物包封率可达43.6%～84.8%,比文献报道的(约15.1%)高2～4倍.在Na2HPO4-KH2PO4缓冲溶液(pH=7.4)和柠檬酸钠-盐酸缓冲溶液(pH=3.9)中进行的药物释放实验表明,5-氟<span style=\"color:red\">尿嘧啶</span>与壳聚糖的质量投料比,戊二醛用量及释药介质的pH值均对微球的释药速率产生影响:随着m(5-Fu)/m(CS)比的减小,微球的释药速率减慢;随着n(CHO)/n(NH2)比的增大,微球的释药速率减慢;在酸性条件下的缓释效果更好.IR和SEM对微球进行的结构表征和形态观察表明,壳聚糖与5-氟<span style=\"color:red\">尿嘧啶</span>之间有比较强的分子间作用力,微球球形规整,分散性好,粒径分布在1～5 μm之间.","authors":[{"authorName":"何强芳","id":"2eb1176f-c170-4f4a-8920-b5ba9ec52ca7","originalAuthorName":"何强芳"},{"authorName":"李国明","id":"b5b5590b-e0b2-45e5-84f8-a8c6f64f6152","originalAuthorName":"李国明"},{"authorName":"巫海珍","id":"f989cc0a-d5ff-4bf5-aaa4-a2257e6d01f9","originalAuthorName":"巫海珍"},{"authorName":"卢志敏","id":"04c3ed76-8cd8-46c1-a440-a70a08d0db6a","originalAuthorName":"卢志敏"},{"authorName":"李良","id":"83423007-6775-44d2-b5e7-f7ac3157aa2e","originalAuthorName":"李良"}],"doi":"10.3969/j.issn.1000-0518.2004.02.019","fpage":"192","id":"90dee226-0e4e-4a9f-8844-04dc03d9ef60","issue":"2","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"4de62d6e-4155-40ae-8d61-4834571b1774","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"8e83e5f1-09e5-48e5-8246-6bc7a8b2cb65","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"ceb33f34-4768-4c91-87e6-e41c06dccf9b","keyword":"微球","originalKeyword":"微球"},{"id":"a53dd171-b9b4-4fd7-9ac6-c140acb6033d","keyword":"药物缓释剂亮","originalKeyword":"药物缓释剂亮"}],"language":"zh","publisherId":"yyhx200402019","title":"5-氟<span style=\"color:red\">尿嘧啶</span>壳聚糖微球的制备及其释药性能","volume":"21","year":"2004"},{"abstractinfo":"以乙酰乙酸乙酯和尿素为原料,用对甲苯磺酸作催化剂合成6-甲基<span style=\"color:red\">尿嘧啶</span>,探讨了不同相转移催化剂、带水剂、相转移催化剂用量及脱水缩合时间等因素对反应产物产率的影响。得出最佳工艺条件为：19．8mL乙酰乙酸乙酯、10g尿素,对甲苯磺酸1．2g,150mL石油醚作带水剂,0．3g聚乙二醇200作相转移催化剂,回流脱水缩合8h,产率可达78%。","authors":[{"authorName":"邢晓轲","id":"6350b00b-ec9b-49a9-8190-b5fb4a5879f0","originalAuthorName":"邢晓轲"},{"authorName":"李建辉","id":"b7047a9e-a9a6-4b71-8816-14e1e8889e0e","originalAuthorName":"李建辉"},{"authorName":"卫世乾","id":"b47efd7c-0b76-4d95-b4b7-42db86ad019c","originalAuthorName":"卫世乾"}],"doi":"","fpage":"71","id":"bc6ba5ac-65f7-496a-aba5-30759d2f9f70","issue":"1","journal":{"abbrevTitle":"HCCLLHYYY","coverImgSrc":"journal/img/cover/HCCLLHYYY.jpg","id":"42","issnPpub":"1671-5381","publisherId":"HCCLLHYYY","title":"合成材料老化与应用"},"keywords":[{"id":"79b5e97f-4a19-4c7e-8873-0aa366de64b8","keyword":"聚乙二醇200","originalKeyword":"聚乙二醇200"},{"id":"3ac76bee-4e4b-48e7-bd1e-aa52d7ef9605","keyword":"6-甲基<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"6-甲基尿嘧啶"},{"id":"44a9b482-8d17-47fa-ad3a-9b681ff4bfc6","keyword":"相转移催化剂","originalKeyword":"相转移催化剂"},{"id":"22b119e1-a163-4f6d-ab8a-4206612d8667","keyword":"合成","originalKeyword":"合成"}],"language":"zh","publisherId":"hccllhyyy2015010020","title":"聚乙二醇200相转移催化合成6-甲基<span style=\"color:red\">尿嘧啶</span>?","volume":"","year":"2015"},{"abstractinfo":"以二环己基碳二亚胺为脱水剂,meso-四(对羟基苯基)卟啉与5-氟<span style=\"color:red\">尿嘧啶</span>-1-基乙酸反应,合成了一种新型meso-四[4-(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基乙酰氧基)苯基]卟啉化合物(A),产率12.7％；将其与乙酸锌反应得到其锌配合物(B),产率30.8％.通过1H NMR、IR、MS、UV-Vis及元素分析确证了卟啉化合物A及其锌配合物B的结构.","authors":[{"authorName":"扈靖","id":"b413fdea-4f18-4884-bc04-0bcbf6b23841","originalAuthorName":"扈靖"},{"authorName":"刘彦钦","id":"b1cdba1f-cd65-41b3-a6a1-12d1bbf624ad","originalAuthorName":"刘彦钦"},{"authorName":"韩士田","id":"55eebe00-7c84-4e1d-b4e7-8a72d6bbb5a0","originalAuthorName":"韩士田"}],"doi":"10.3724/SP.J.1095.2012.00298","fpage":"608","id":"e0efb87d-2a09-4d78-83fd-e545dfc64576","issue":"5","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"c6fcfd7c-a25f-4fad-83ee-618e2eef56ef","keyword":"卟啉","originalKeyword":"卟啉"},{"id":"ed747e4d-05cf-4b6e-9ca0-3d56f5b9c14f","keyword":"卟啉锌","originalKeyword":"卟啉锌"},{"id":"95018847-31bd-4ea8-968e-7c19022543a2","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"f6212148-85dc-4109-bde5-26e4719c8ac8","keyword":"合成","originalKeyword":"合成"}],"language":"zh","publisherId":"yyhx201205020","title":"四(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基乙酰氧基苯基)卟啉及其锌配合物的合成","volume":"29","year":"2012"},{"abstractinfo":"用5-[3-(3-溴丙氧基)苯基]-10,15,20-三(3-氯苯基)卟啉或5-[3-(4-溴丁氧基)苯基]-10,15,20-三(3-氯苯基)卟啉与5-氟<span style=\"color:red\">尿嘧啶</span>反应,合成了1,3-二[5-(3-丙氧基苯基)-10,15,20-三(3-氯苯基)卟啉]-5-氟<span style=\"color:red\">尿嘧啶</span>(A1)、1-[5-(3-丙氧基苯基)-10,15,20-三(3-氯苯基)卟啉]5-氟<span style=\"color:red\">尿嘧啶</span>(B1)、1,3-二[5-(3-丁氧基苯基)-10,15,20-三(3-氯苯基)卟啉]-5-氟<span style=\"color:red\">尿嘧啶</span>(A2)、1-[5-(3-丁氧基苯基)-10,15,20-三(3-氯苯基)卟啉]-5-氟<span style=\"color:red\">尿嘧啶</span>(B2),产率分别为20.4%、12.3%、21.4%、11.4%.通过红外光谱、紫外可见光谱、核磁共振谱和基质辅助激光解吸-电离飞行时间质谱测试技术表征了其结构.对目标化合物的合成分离纯化条件进行了研究.结果表明,选择DMF为溶剂,反应温度在120℃,反应时间10 h,产率较高;采用硅胶G(粒径40μm)柱层析,按试验产品量,柱子直径为3 cm,柱高10 cm,用V(氯仿)∶V(丙酮)=15∶1为洗脱剂,分离效果较好.","authors":[{"authorName":"高书涛","id":"bd1e061f-75e7-49fa-9269-603b98ce51f1","originalAuthorName":"高书涛"},{"authorName":"刘彦钦","id":"2bf74035-f404-4ff9-8c6c-d4bf359a2555","originalAuthorName":"刘彦钦"},{"authorName":"韩士田","id":"5ae68dd3-4880-4cae-87ca-cc7e2290c5dc","originalAuthorName":"韩士田"}],"doi":"10.3969/j.issn.1000-0518.2007.11.015","fpage":"1295","id":"c481ec3f-a244-45d1-bf2f-2d17cd05cb35","issue":"11","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"78f0daf5-31e1-4e12-9857-dab977c5c5c6","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"017dbb99-fcae-49e6-bd44-1c8670f1e873","keyword":"卟啉","originalKeyword":"卟啉"},{"id":"b73435d3-380e-47b4-bcf7-78e863422ca4","keyword":"合成","originalKeyword":"合成"},{"id":"a2801c92-16e6-419a-8cb2-738f6a890eb1","keyword":"结构表征","originalKeyword":"结构表征"}],"language":"zh","publisherId":"yyhx200711015","title":"新型间氯苯基卟啉-5-氟<span style=\"color:red\">尿嘧啶</span>化合物的合成与表征","volume":"24","year":"2007"},{"abstractinfo":"采用硫酸钠和三聚磷酸钠为交联剂,通过微乳液-离子交联法制备了壳聚糖/5-氟<span style=\"color:red\">尿嘧啶</span>纳米粒子. 所制得的粒子均呈单分散、形状规则的球形. 其中用硫酸钠制备的粒子粒径为100 nm左右,载药量30%,包封率80%;用三聚磷酸钠制备的粒子粒径为40～80 nm,载药量21%,包封率55%. 在pH＝1的HCl溶液和pH＝7.4的磷酸盐缓冲液中,进行粒子体外释药性能研究的结果表明,粒子释药量随释放时间增加而增大;相同释放时间内,粒子在磷酸盐缓冲液中的释药量明显小于在HCl溶液中的释药量. 将载药粒子与K562肿瘤细胞共同培养,细胞凋亡率随着培养时间的增加而缓慢增加,表明粒子在细胞培养液中的释药量随培养时间的增加而增大,能明显促进细胞凋亡.","authors":[{"authorName":"陈艳","id":"1ecc444e-fd99-47cd-bb31-d0ed72be9880","originalAuthorName":"陈艳"},{"authorName":"沈鹤柏","id":"f4fb7a8c-b3b3-4e70-ad10-5888b6ce2f81","originalAuthorName":"沈鹤柏"},{"authorName":"徐瑞云","id":"a0c5d408-14eb-4f62-bebe-12de2c40e2da","originalAuthorName":"徐瑞云"},{"authorName":"朱龙章","id":"d134ddca-ddde-480f-bdf9-f9a89df4c7ad","originalAuthorName":"朱龙章"}],"doi":"10.3969/j.issn.1000-0518.2008.05.014","fpage":"564","id":"4400ecc9-1026-4d48-8605-713f3cb2a4d9","issue":"5","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"bf5f9a54-a737-4a64-90cc-ed082e6aa6e2","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"634f69ef-b52b-48a0-9f6f-da9c020a37fa","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"6aed86f0-98e4-470a-8c6b-50069c1e1e2e","keyword":"微乳液","originalKeyword":"微乳液"},{"id":"9d0715aa-431f-4469-b5fb-ec74922aab93","keyword":"离子交联剂","originalKeyword":"离子交联剂"},{"id":"9fd8150a-c14d-4aaa-940d-7b6f3f428a36","keyword":"纳米粒子","originalKeyword":"纳米粒子"}],"language":"zh","publisherId":"yyhx200805014","title":"壳聚糖/5-氟<span style=\"color:red\">尿嘧啶</span>纳米粒子的制备及其性能","volume":"25","year":"2008"},{"abstractinfo":"为提高5-氟<span style=\"color:red\">尿嘧啶</span>抗癌的靶向性,降低其不良反应,合成了5种新型卟啉-5-氟<span style=\"color:red\">尿嘧啶</span>衍生物及其Mn3+配合物,优化了合成反应条件,探索了目标化合物的分离方法.通过IR、UV-Vis、1H NMR和ESI-MS对化合物结构和组成进行了确认.采用四甲基偶氮唑蓝(MTT)比色法,以5-氟<span style=\"color:red\">尿嘧啶</span>为阳性对照药,测试了卟啉化合物对5种肿瘤细胞的体外抑制活性.初筛结果显示,化合物D3对人卵巢癌细胞Sk-ov-3有较强的抑制作用.","authors":[{"authorName":"李雅","id":"388eaf5e-081d-496c-b455-631b8a02c97c","originalAuthorName":"李雅"},{"authorName":"申利红","id":"b52f7335-1489-4cb3-a21f-f5c6391b7429","originalAuthorName":"申利红"},{"authorName":"王建森","id":"60ee6d00-96dc-4bfa-be8e-0a5d7c2817f0","originalAuthorName":"王建森"},{"authorName":"韩士田","id":"d0166bfd-2ec4-4b19-8273-4a5143c2812f","originalAuthorName":"韩士田"}],"doi":"10.3724/SP.J.1095.2013.20012","fpage":"38","id":"b5ac2fb2-7019-4114-bcd8-58af5755d2db","issue":"1","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"7ee181cd-873d-4495-ac3c-9c2f88b45026","keyword":"四苯基卟啉","originalKeyword":"四苯基卟啉"},{"id":"d6ee4f85-d8e9-43c2-b5ec-a1eae431aabe","keyword":"氟<span style=\"color:red\">尿嘧啶</span>衍生物","originalKeyword":"氟尿嘧啶衍生物"},{"id":"e1f1132b-16d8-48b2-97e2-bb2be8ff4a77","keyword":"合成","originalKeyword":"合成"},{"id":"f6900f5e-4516-4efb-b768-18f1fda72dac","keyword":"体外抗癌活性","originalKeyword":"体外抗癌活性"}],"language":"zh","publisherId":"yyhx201301007","title":"5-氟<span style=\"color:red\">尿嘧啶</span>-1-烷氧苯基三间氯苯基卟啉的合成及其体外抗癌活性","volume":"30","year":"2013"},{"abstractinfo":"合成了4种5-氟<span style=\"color:red\">尿嘧啶</span>-卟啉衍生物:5-[3-(2-(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)卟啉(1a)、5-[3-(2-(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基)乙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2a)、5-[3-(3-(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基)丙氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2b)和5-[3-(4-(5-氟<span style=\"color:red\">尿嘧啶</span>-1-基)丁氧基)苯基]-10,15,20-三(3-氯苯基)锰卟啉(2c),通过UV-Vis、IR、MS及元素分析表征了它们的结构.用噻唑蓝法(MTT法)测定了化合物2a、2b和2c对人胃癌细胞株BGC-823的抑制活性.化合物2b的半数抑制浓度IC50为1.34μmol/L,表明有一定的细胞毒作用.","authors":[{"authorName":"韩军兴","id":"35d6a6ea-8cb7-4ea3-8605-5cbb3e7edfef","originalAuthorName":"韩军兴"},{"authorName":"刘彦钦","id":"598a1aa8-0de6-46dd-883f-091968c02abc","originalAuthorName":"刘彦钦"},{"authorName":"韩士田","id":"e784af34-d86e-4dba-b8d4-f675cff27a07","originalAuthorName":"韩士田"}],"doi":"10.3724/SP.J.1095.2012.00354","fpage":"718","id":"eeec8b30-c4ba-42f9-9135-d76e5f577dcb","issue":"6","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"d412e1cd-7669-4584-841b-924e7fe1348f","keyword":"锰卟啉","originalKeyword":"锰卟啉"},{"id":"3220dc10-b7de-405c-9cb2-b330a4da1fd7","keyword":"氟<span style=\"color:red\">尿嘧啶</span>","originalKeyword":"氟尿嘧啶"},{"id":"4689d4dd-fb69-4c1b-ae30-147b83942e7e","keyword":"合成","originalKeyword":"合成"},{"id":"fc7aa951-9b65-4a74-aae6-d022a1de0b73","keyword":"人胃癌细胞株BGC-823","originalKeyword":"人胃癌细胞株BGC-823"}],"language":"zh","publisherId":"yyhx201206018","title":"间氯苯基锰卟啉-5-氟<span style=\"color:red\">尿嘧啶</span>配合物的合成及其对癌细胞的抑制活性","volume":"29","year":"2012"}],"totalpage":14,"totalrecord":139}