采用微波协助冻融法制备了包埋苯妥英钠的具有葡聚糖微结构的聚乙烯醇凝胶（Dex/PVA BHMs）敷料。结果表明,Dex/PVA BHMs凝胶的溶胀率和拉伸强度分别为19.3%和1.05MPa,溶胀率比传统聚乙烯醇（PVA）凝胶的提高了近2.5倍,但拉伸强度变化较小,使其获得了良好的稀释膨胀性能且保留了PVA凝胶高力学强度的优点;包药Dex/PVABHMs凝胶在pH=7.4缓冲溶液中6h达到释放平衡,累计释药率为81.2%,与PVA凝胶相比呈现显著缓释特性;包药的Dex/PVA BHMs凝胶敷料能明显促进大白鼠背部烧伤处伤口的愈合,10 d内伤口完全愈合且无疤痕存在。
A new PVA hydrogels dressing with dextran microgel structures（Dex/PVA BHMs）coupled with phenytoin sodium was designed and prepared by the microwave-assisted freezing-thawing（F-T） method.The results show that the swelling ratio of dex/PVA BHMs gel is 19.3% which is nearly 2.5 times higher than traditional PVA gel;and the compression strength is 1.05 MPa which is almost the same like traditional PVA gel.Dex/PVA BHMs gel obtains a good dilute expansion property and retains the advantages of high mechanical strength of PVA gel.The drug release in the pH7.4 buffer solution achieves the release balance within 6 h.The cumulative release percentage is 81.2%,showing a significant slow-release property compared with the traditional PVA gel.Dex/PVA BHMs gel coupled with phenytoin sodium could significantly promote the wound healing of rats.The wound is completely healed within 10 days and no obvious scar there.
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