药用辅料是药物制剂的基础材料和重要组成部分,缓释制剂中起缓释作用的辅料多为高分子化合物.综述了高分子材料纤维素醚类衍生物中羧甲基纤维素钠、甲基纤维素、乙基纤维素、羟丙基甲基纤维素和羟丙基纤维素等作为药用辅料在缓释制剂中的应用,并展望了其应用前景.
参考文献
| [1] | Kevin J. Edgar;Charles M. Buchanan;John S. Debenham;Paul A. Rundquist;Brian D. Seiler;Michael C. Shelton;Debra Tindall .Advances in cellulose ester performance and application[J].Progress in Polymer Science,2001(9):1605-1688. |
| [2] | Fundueanu G;Constantin M;Esposito E et al.Cellulose acetate butyrate microcapsules containing dextran ion-exchange resins as self-propelled drug release system[J].Biomaterials,2005,26:4337. |
| [3] | Vueba ML;Batista De Carvalho LA;Veiga F;Sousa JJ;Pina ME .Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2004(1):51-59. |
| [4] | Michailova V;Titeva St;Kotsilkova R et al.Influence of aqueous medium on viscoelastic properties of carboxymethylcellulose sodium, hydroxypropyimethyl cellulose, and thermally pre-gelatinized starch gels[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,1999,149:515. |
| [5] | 任耘;盛秉丽;彭军 .牙用替硝唑缓释药膜的制备及临床应用[J].河北医药,2000,22(05):350. |
| [6] | 崔保菊.妇乐宁缓释药膜的制备与临床应用[J].医药导报,2002(09):575-576. |
| [7] | 富志军,周东新,钟鸣.复方中药口腔粘膜粘附缓释膜的研究[J].中国药科大学学报,2001(05):13-16. |
| [8] | 郭曙刚,陈邦银,张汉萍.尼美舒利缓释片的研制和体外溶出度[J].中国医院药学杂志,2000(07):398-400. |
| [9] | Crowley MM;Schroeder B;Fredersdorf A;Obara S;Talarico M;Kucera S;McGinity JW .Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.[J].International Journal of Pharmaceutics,2004(2):509-522. |
| [10] | Pearnchob N;Bodmeier R .Coating of pellets with micronized ethylcellulose particles by a dry powder coating technique.[J].International Journal of Pharmaceutics,2003(1/2):1-11. |
| [11] | Wu PC;Huang YB;Chang JI;Tsai MJ;Tsai YH .Preparation and evaluation of sustained release microspheres of potassium chloride prepared with ethylcellulose.[J].International Journal of Pharmaceutics,2003(1):115-121. |
| [12] | Pather S I;Irina Russell;James A Syce et al.Sustained release theophylline tablets by direct compression Part 1 : formulation and in vitro testing[J].International Journal of Pharmaceutics,1998,164:1. |
| [13] | 程刚,邹梅娟,肖云彩,崔福德,冯金华.结肠定位释药双氯芬酸钠包衣片的制备和体外释放[J].中国药学杂志,2003(01):39-42. |
| [14] | Wakerly Z;Fell J T;Attwood D et al.Studies on drug release from pectin/ethlycellulose film-coated tablets: a potential colonic delivery system[J].International Journal of Pharmaceutics,1997,153:219. |
| [15] | Zhang ZY.;Xiao B.;Ping QN. .Microencapsulation and characterization of tramadol-resin complexes[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2000(2/3):107-113. |
| [16] | 陈挺,靳松,陈庆华.乙基纤维素水分散体包衣微丸的体外释药特性研究[J].中国药科大学学报,2000(01):25. |
| [17] | 黄静琳,陆锦芳.甲硝唑生物粘附微球的体外释药及其粘附性[J].药学学报,2002(03):226-228. |
| [18] | Mahaguna V;Talbert RL;Peters JI;Adams S;Reynolds TD;Lam FY;Williams RO .Influence of hydroxypropyl methylcellulose polymer on in vitro and in vivo performance of controlled release tablets containing alprazolam.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2003(3):461-468. |
| [19] | Siepmann J;Peppas N A .Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose(HPMC)[J].Advanced Drug Delivery Reviews,2001,48(2-3):139. |
| [20] | Gustafsson C;Bonferoni M C;Caramella C et al.Characterisation of particle properties and compaction behaviour of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitution[J].European Journal of Pharmaceutical Sciences,1999,9(02):171. |
| [21] | Lee BJ;Ryu SG;Cui JH .Controlled release of dual drug-loaded hydroxypropyl methylcellulose matrix tablet using drug-containing polymeric coatings.[J].International Journal of Pharmaceutics,1999(1):71-80. |
| [22] | Nellore RV.;Hussain AS.;Tillman LG.;Augsburger LL.;Rekhi GS. .Development of metoprolol tartrate extended-release matrix tablet formulations for regulatory policy consideration[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,1998(1/3):247-256. |
| [23] | Sangalli ME.;Zema L.;Busetti C.;Giordano F.;Gazzaniga A.;Maroni A. .In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2001(1):103-110. |
| [24] | Li YH;Zhu JB .Modulation of combined-release behaviors from a novel "tablets-in-capsule system"[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(3):381-389. |
| [25] | Alvarez-Lorenzo C;Castro E;Gomez-Amoza J L .Intersupplier and interlot variability in hydroxypropyl celluloses: implications for theophylline release from matrix tablets[J].Pharmaceutica Acta Helvetiae,1998,73(02):113. |
| [26] | 李洪奎.双氯芬酸钠缓释片人体体内外相关性研究[J].中国药房,1997(05):203-204. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%