欢迎登录材料期刊网

材料期刊网

中国科学院金属研究所 科学出版社
高级检索
  1. 首页
  2. 期刊
  3. 材料导报
  4. 生物降解材料聚乳酸的共聚改性研究进展

材料导报, 2005, 19(12): 23-26.

生物降解材料聚乳酸的共聚改性研究进展

姚军燕 1, , 杨青芳 2, , 范晓东 3, , 郑亚萍 4, , 舒晓军 5,

1.西北工业大学理学院,西安,710072

2.西北工业大学理学院,西安,710072

3.西北工业大学理学院,西安,710072

4.西北工业大学理学院,西安,710072

5.西北工业大学理学院,西安,710072

基金项目:   西北工业大学校科研和教改项目(5210102-M16204)  

关键词： 聚乳酸 , 丙交酯 , 生物医用材料 , 共聚 , 改性

Recent Copolymerization Researches of Biodegradable Poly(lactic acid)

概述了生物降解材料聚乳酸的物理机械性能和生物性能,指出对聚乳酸进行改性的必要性及常用方法,其中共聚改性方法是最有效的途径之一.综述了聚乳酸与聚乙醇酸、聚己内酯、聚乙二醇、聚氨基酸等的共聚方法、共聚物的性能及其应用.经共聚改性后聚乳酸的力学性能、亲水性能或反应功能性能可以得到改善,降解周期可实现调控,从而满足在生物医学及环保方面的应用需求.

参考文献

[1] 俞耀庭;张兴栋.生物医用材料[M].天津:天津大学出版社,2000
[2] 姚军燕,秦能,杨青芳.生物医用高分子材料聚乳酸的成型方法研究[J].塑料工业,2004(10):6-8,14.
[3] 姚军燕,杨青芳,马强.生物高分子材料聚乳酸的改性研究进展[J].高分子材料科学与工程,2004(04):28-32.
[4] Bechtold K .Perfectly alternating copolymer of lactic acid and ethylene oxide as a plasticizing agent for polylactide[J].Macromolecules,2001,34:8641.
[5] Liu X .Thermal and mechanical properties of poly (lactic acid)and poly(ethylene/butylene succinate)blends[J].Journal of Environmental Polymer Degradation,1997,5:225.
[6] Ohkoshi I.;Doi Y.;Abe H. .Miscibility and solid-state structures for blends of poly[(S)-lactide] with atactic poly[(R,S)-3-hydroxybutyrate][J].Polymer: The International Journal for the Science and Technology of Polymers,2000(15):5985-5992.
[7] Sheth M.;Dave V.;Gross RA.;Mccarthy SP.;Kumar RA. .BIODEGRADABLE POLYMER BLENDS OF POLY(LACTIC ACID) AND POLY(ETHYLENE GLYCOL)[J].Journal of Applied Polymer Science,1997(8):1495-1505.
[8] Grijpma D W;Van Hofslot R D A;Super H et al.Rubber toughening of poly(lactide)by blending and block copolymerization[J].Journal of Polymer Science Eng,1994,34:1674.
[9] Sun Xiuzhi S;Seib Paul;Wang Hua .High strength plastic from reactive blending of starch and polylactic acids[P].US:6211325,2001-04-03.
[10] Hiki S.;Kimura Y.;Miyamoto M. .Synthesis and characterization of hydroxy-terminated [RS]-poly(3-hydroxybutyrate) and its utilization to block copolymerization with L-lactide to obtain a biodegradable thermoplastic elastomer[J].Polymer: The International Journal for the Science and Technology of Polymers,2000(20):7369-7379.
[11] JACOBSEN S.;FRITZ H.G. .Plasticizing Polylactide-The Effect of Different Plasticizers on the Mechanical Properties[J].Polymer engineering and science,1999(JULY):1303-1310.
[12] 全大萍,江昕,李世普.聚乳酸及其复合材料的研究概况[J].武汉工业大学学报,1996(02):114-117.
[13] 江涛,胡平.生物医用高分子材料自增强工艺的研究[J].功能材料,2001(04):353-355.
[14] Vasenius Jarkko;Majola Ari;Miettinen Eeva-Liisa et al.Do intramedullary rods of self-reinforced poly-L-lactide or poly-DL/L-lactide cause lactic acid acidosis in rabbits[J].Clinical Materials,1992,10(04):213.
[15] 赵耀明;黄俊豪;陈军武 等.生物降解医用材料-聚乙丙交酯的研究[J].合成纤维工业,1997,20(04):1.
[16] Viljanen J.;Bondestam S.;Majola A.;Rokkanen P.;Tormala P.;Kinnunen J. .BONE CHANGES AFTER EXPERIMENTAL OSTEOTOMIES FIXED WITH ABSORBABLE SELF-REINFORCED POLY-L-LACTIDE SCREWS OR METALLIC SCREWS STUDIED BY PLAIN RADIOGRAPHS, QUANTITATIVE COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING[J].Biomaterials,1995(17):1353-1358.
[17] Lewis D H.Biodegradable polymers as dray delivery systems[M].NewYork,1990
[18] 郯志清;沈新元;孙瑾 等.一种聚酯类可吸收医用缝合线的制造方法[P].CN:1195559,1998-04-16.
[19] 叶卫平.己内酯丙交酯嵌段共聚生物降解材料的生物学性能研究[J].生殖医学杂志,1996(01):43.
[20] Mangkorn Srisa-ard;Robert Molloy;Nipapan Molloy;Jintana Siripitayananon;Mntira Sriyai .Synthesis and characterization of a random terpolymer of L-lactide, #epsilon#-caprolactone and glycolide[J].Polymer international,2001(8):891-896.
[21] Dong Changming;Qiu Kunyuan;Gu Zhongwei et al.Synthesis of star-shaped poly(ε-caprolactone)-b- poly(DL-lactic acid-alt-glycolic acid)with multifunctional initiator and stannous octoate catalyst[J].Macromolecules,2001,34:4691.
[22] 宋谋道;余艺华;刘升 .乳酸、羟基乙酸均聚物及共聚物的合成与结构表征[J].离子交换与吸附,1995,11(03):245.
[23] 邓联东,孙多先,霍建中,靳建洲,董岸杰.聚乙二醇/聚己内酯两亲性三嵌段共聚物纳米胶束[J].高分子材料科学与工程,2004(02):217-219,223.
[24] Otsuka H;Nagasaki Y;Kataoka K .Dynamic wettability study on the functionalized PEGylated layer on a polylactide surface constructed by the coating of aldehyde-ended poly (ethylene glycol) (PEG)/polylactide(PLA) block copolymer[J].Science and Technology of Advanced Materials,2001,1:21.
[25] Kim S Y;Kim J H;Kim D et al.Drug-releasing kinetics of MPEG/PLLA block copolymer micelles with different PLLA block lengths[J].Journal of Applied Polymer Science,2001,82:2599.
[26] 宋谋道,朱吉亮,张邦华,郝广杰,周庆业,张莹,赵芬芝,赵英奇,杨世强,范玉玲.聚乙二醇改性聚乳酸的研究[J].高分子学报,1998(04):0.
[27] Metters A.T. .Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel[J].Polymer: The International Journal for the Science and Technology of Polymers,2000(11):3993-4004.
[28] 王定国;胡嘉颖 .生物降解材料聚乳酸-聚乙二醇共聚物体内外降解[J].北京生物医学工程,1996,15(02):103.
[29] Kimura Y;Matsuzaki Y;Yamane H et al.Preparation of block copoly(ester-ether)comprising poly(L-lactide)and poly(oxypropylene)and degradation of its fibre in vitro and in vivo[J].Polymer,1989,30:1342.
[30] Barrera D A;Zylstra E;Langer R et al.Synthesis and RGD peptide modification of a new biodegradable copolymer Poly(lactic acid-co-lysine)[J].Journal of the American Chemical Society,1993,115:11010.
[31] Barrera DA.;Lansbury PT.;Langer R.;Zylstra E. .COPOLYMERIZATION AND DEGRADATION OF POLY(LACTIC ACID CO-LYSINE)[J].Macromolecules,1995(2):425-432.
[32] Ohya Y;Matsunami;Hideaki Ouchi T et al.Cell attachment and growth on films prepared from poly(depsipeptideco-lactide) having various functional groups[J].Journal of Biomedical Materials Research,2003,65A:79.
[33] Ouchi T.;Ohya Y. .Design of lactide copolymers as biomaterials[J].Journal of Polymer Science, Part A. Polymer Chemistry,2004(3):453-462.
[34] Deng XM.;Liu Y.;Yuan ML. .Study on biodegradable polymer. 3. Synthesis and characterization of poly(DL-lactic acid)-co-poly(ethylene glycol)-co-poly(L-lysine) copolymer[J].European Polymer Journal,2002(7):1435-1441.
[35] Liu Y.;Yuan ML.;Deng XM. .Study on biodegradable polymers: synthesis and characterization of poly(DL-lactic acid-co-L-lysine) random copolymer[J].European Polymer Journal,2003(5):977-983.
[36] Park S Y Han;Dong Keun;Kim Sung Chul .Synthesis and characterization of star-shaped PLLA-PEO block copolymers with temperature-sensitive sol-gel transition behavior[J].Macromolecules,2001,34:8821.
[37] Super H;Gripman D W;Pennings A J .Incorporation of salicylates into poly (L-lactide)[J].Polymer Bull(Berlin),1994,32(5-6):509.
[38] 范昌烈.DL-丙交酯与2-氢-2-氧-1，3，2-二氧磷杂环己烷的开环共聚合研究[J].高等学校化学学报,1995(06):971.
[39] Shinoda H;Matyjaszewski K .Structural control of poly (methyl methacrylate)-g-poly(lactic acid)graft copolymers by atom transfer radical polymerization(ATRP)[J].Macromolecules,2001,34:6243.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
作者相关
文章评分
  • 您的评分：
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%

版权所有©2010中国科学院金属研究所中国科技出版传媒股份有限公司

本系统由北京仁和汇智信息技术有限公司设计开发

技术支持：info@rhhz.net