以聚丙交酯-乙交酯(PLGA)50/50与75/25为原料,采用流延法制成薄膜,其中包括PLGA50/50单成分膜、PLGA75/25单成分膜、两者的共混膜以及成分非均匀分布的梯度膜,将4种不同类型的膜浸泡在37℃、PH=7.4的磷酸盐缓冲液中进行体外降解实验.对4种膜降解过程中的分子量、质量损失、吸水率、pH值以及表面形貌等性能进行分析.结果表明,PLGA梯度膜具有最平稳的降解特性.
参考文献
| [1] | Loo JS;Ooi CP;Boey FY .Degradation of poly(lactide-co-glycolide) (PLGA) and poly(l-lactide) (PLLA) by electron beam radiation.[J].Biomaterials,2005(12):1359-1367. |
| [2] | 李孝红;袁明龙;熊成东 等.[J].高分子通报,1999,3(08):24-32. |
| [3] | Athanasiou KA.;Agrawal CM.;Niederauer GG. .STERILIZATION, TOXICITY, BIOCOMPATIBILITY AND CLINICAL APPLICATIONS OF POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMERS[J].Biomaterials,1996(2):93-102. |
| [4] | 刘洪泽,齐民,魏志勇,刘丽波.本体溶蚀型药物传输系统的数学模型[J].中国组织工程研究与临床康复,2009(52):10340-10344. |
| [5] | Zolnik BS;Burgess DJ .Effect of acidic pH on PLGA microsphere degradation and release[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2007(3):338-344. |
| [6] | Nie HM;Lee LY;Tong H;Wang CH .PLGA/chitosan composites from a combination of spray drying and supercritical fluid foaming techniques: New carriers for DNA delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2008(3):207-214. |
| [7] | Lao LL;Venkatraman SS;Peppas NA .Modeling of drug release from biodegradable polymer blends.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(3):796-803. |
| [8] | 齐民,刘洪泽,魏志勇,黄莹莹.聚乳酸-乙醇酸膜在模拟体液中降解的Monte Carlo 模拟[J].中国组织工程研究与临床康复,2008(06):1153-1156. |
| [9] | Joachim L S C;Jason Tan W L;Khoa S M et al.[J].International Journal of Pharmaceutics,2008,360(1-2):228-230. |
| [10] | Zolnik BS;Leary PE;Burgess DJ .Elevated temperature accelerated release testing of PLGA microspheres[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2006(3):293-300. |
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