以壳聚糖(CS),L-天冬氨酸(ASP)和戊二醛(GA)为原料,合成了具有pH、离子强度敏感性的壳聚糖水凝胶CS-GA-ASP.研究了交联剂含量、pH、离子强度对水凝胶溶胀率的影响和水凝胶对辅酶A的控制释放.结果表明,水凝胶在酸性溶液中,溶胀率最大,在中性溶液中溶胀率最小;水凝胶在不同pH或不同离子强度的溶液中交替放置时,表现出良好的溶胀-退胀可逆性;在室温下,pH=3.7、6.8、9的缓冲溶液中,辅酶A的累积释放率分别为78%、92%和87%,且在pH=6.8的缓冲溶液中,辅酶A释放速率最快,在pH=3.7的缓冲溶液中时,辅酶A释放速率最慢.
参考文献
| [1] | Rudolf R;Thomas S;Dirk K et al.[J].Macromolecular Symposia,2004,210(01):501-511. |
| [2] | Dipti S;Dirk K;Veena C et al.[J].Polym for Advan Techno,2006,17(03):186-192. |
| [3] | Li Hua;Wang Xiaogui;Wang Zijie et al.[J].Macromole Biosci,2005,5(09):904-914. |
| [4] | Ho Jin C;Jin W B;Hyung D P et al.[J].Macromolecular Symposia,2005,224(01):275-286. |
| [5] | Okano T;Kikuchi A;Sakurai Y et al.[J].J Controll Release,1995,36:125-133. |
| [6] | Kawaguchi H;Fujimoto K;Mizuhara Y .[J].Colloid and Polymer Science,1992,270:53-57. |
| [7] | Cicek H.;Tuncel A. .Immobilization of alpha-chymotrypsin in thermally reversible isopropylacrylamide-hydroxyethylmethacrylate copolymer gel[J].Journal of Polymer Science, Part A. Polymer Chemistry,1998(4):543-552. |
| [8] | Fatiha C;Maryam T;Severian D et al.[J].J Biomedic Materi Rese,2000,51(01):107-116. |
| [9] | 鲁从华,罗传秋,曹维孝.壳聚糖的改性及其应用[J].高分子通报,2001(06):46-53. |
| [10] | Pornsak S;Satit P .[J].Macromolecular Symposium,2004,216:17-21. |
| [11] | 吴国杰,崔英德.壳聚糖/聚醚半互穿网络水凝胶的合成与力学性能的研究[J].功能材料,2005(09):1386-1388. |
| [12] | Li Yeping;Li Liu;Fang Yue-e .[J].Polym Interna,2003,52(02):285-290. |
| [13] | Sangamesh G K;Kumaresh S S;Tejraj M.[J].Journal of Applied Polymer Science,2003(87):1526-1536. |
| [14] | Wang Qun;Du Yumin;Fan Lihong.[J].Journal of Applied Polymer Science,2005(96):808-813. |
| [15] | Baker J P;Stephens D R;Blanch H W et al.[J].Macromolecules,1992,25:1995. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%