以表面溶蚀性可降解聚合物聚三亚甲基碳酸酯（PTMC）为载体,分别采用超声雾化喷涂技术和溶液浇注法制备了以PTMC为涂层载体的他克莫司药物洗脱支架和载药薄膜。傅里叶红外光谱（FT-IR）结果显示他克莫司分散在PTMC中。扫描电子显微镜观察支架撑开后的药物涂层保持连续均匀,没有开裂和剥落。他克莫司洗脱支架的药物释放行为与Weibull模型的相关性最高。体外血小板粘附和平滑肌粘附、增殖实验表明包载他克莫司的PTMC表面具有显著地抑制血小板粘附和平滑肌增生的作用。
One kind of tacrolimus eluting stent coated with biodegradable poly（1,3-trimethylene carbonate）（PTMC） was developed.The results of Fourier transform infrared spectroscopy（FT-IR） and X-ray diffraction（XRD） analysis proved the chemical stability of tacrolimus loaded in PTMC matrix.Stent coating were examined by scanning electron microscopy（SEM）,indicating that the coating not only was very smooth and uniform but also had the ability to withstand the compressive and tensile strains.In vitro drug release of tacrolimus-eluting stents was similar to the Weibull＇s release mode.The result of in vitro platelets adhesion and human umbilical cord artery smooth muscle cells（HUCASMCs） culture showed the PTMC loaded by tacrolimus could significantly prohibit the adhesion of platelets and the proliferation of HUCASMCs.This work aims to find a better biodegradable polymer which is surface erosion and can be applied as drug-eluting stent coatings.
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