采用硅烷偶联剂对生物活性玻璃(BG)进行表面修饰以改善其与高分子的亲和性.通过溶胶凝胶法制得BG,将氨丙基三乙氧基硅烷(APTES)键连到BG表面,采用FTIR、TG、激光粒度仪等对修饰前后的BG进行表征,并通过细胞实验对材料的细胞相容性进行初步研究.结果表明,修饰后BG的FTIR图谱上出现归属于C-H的伸缩振动吸收峰,在DTG曲线上观察到明显的有机基团燃烧失重峰,表明APTES接枝到生物玻璃表面;而MC-3T3细胞增殖测定和SEM结果显示经表面修饰后的BG更有利于细胞的生长增殖.
参考文献
[1] | Oonishi H,Kushitani S,Yasukawa E,et al.Particulate bioglass compared with hydroxyapatite as a bone graft substitute[J].Clinical Orthopaedics and Related Research,1997,334(1):316-325. |
[2] | Chen Q Z,Thompson I D,Boccaccini A R.4555 Bioglasslderived glass-ceramic scaffolds for bone tissue engineering[J].Biomaterials,2006,27(11):2414-2524. |
[3] | Hench L L,Xynos I.Edgar A,等.激活基因的玻璃[J].无机材料学报,2002,17(5):897-909.Hench L L,Xynos I,Edgar A,et al.Gene activating glasses[J].Journal of Inorganic Materials,2002,17(5):897-909. |
[4] | 钟吉品.生物玻璃的研究与发展[J].无机材料学报,1995,10(2):130-138.Zhong Jipin.Bioactive glasses:Research and applications[J].Journal of Inorganic Materials,1995,10(2):130-138. |
[5] | Heneh L L.The story of Bioglass(R)[J].Journal of Materials Science:Materials in Medicine,2006,17(11):967-978. |
[6] | Superb K M,Dirk M,Tobias J B,et al.Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass(R) composites[J].Biomaterials,2008,29(12):1750-1761. |
[7] | Day R M,Boccaccini A R,Sherey S,et al.Assessment of polyglyeolie acid mesh and bioaetive glass for soft-tissue engineering scaffolds[J].Biomaterials,2004,25(27):5857-5866. |
[8] | Miao X,Tan L P,Tan L S,et al.Porous calcium phosphate ceramics modified with PLGA-bioactive glass[J].Materials Science and Engineering,2007,27(2):710-712. |
[9] | Wilda H,Julie E G.Cell viability,proliferation and extracellular matrix production of human annulus fibrosus cells cultured within PDLLA/Bioglass(R) composite foam scaffolds in vitro[J].Acta Biomaterialia,2008,4(2):230-243. |
[10] | 杜瑞林,倪似愚,常江,等.含Zn生物玻璃、玻璃陶瓷与聚酯复合骨组织工程支架的制备及性能[J].复合材料学报,2008,25(6):123-129.Du Ruilin,Ni Siyu,Chang Jiang,et al.Porous Zn-containing bioactive glass-ceramic and glass -ceramic/polyester composite scaffolds for bone tissue engineering[J].Acta Materiae Compositae Sinica,2008,25(6):123-129. |
[11] | Oana B,Superb M,Ipsita R,et al.In vitro biocompatibility of 45S5 Bioglass(R)-derived glass-ceramic scaffolds coated with poly(3-hydroxybutyrate) I-J].Journal of Tissue Engineering and Regenerative Medicine,2009,3(2):139-148. |
[12] | Davis D H,Giannoulis C S,Johnson R W,et al.Immobilization of RGD to 《111》 silicon surfaces for enhanced cell adhesion and proliferation[J].Biomaterials,2002,23(19):4019-4027. |
[13] | 傅雅琴,俞来明,韩春韶,等.表面改性处理对气相生长碳纤维的微观结构影响[J].复合材料学报,2009,26(5):100-104.Fu Yaqin,Yu Laiming,Han Chunshao,et al.Effects of surface modification on the microstructure of vapor grown carbon fiber[J].Acta Materiae Compositae Sinica,2009,26(5):100-104. |
[14] | 张士华,陈光,崔崇,等.偶联剂处理对玻璃纤维/尼龙复合材料力学性能的影响[J].复合材料学报,2006,23(3):31-36.Zhang Shihua,Chen Guang,Cui Cong,et al.Effect of silicon coupling agent treatment of glass fiber on mechanical properties of GFRMCN[J].Acta Materiae Compositae Sinica,2006,23(3):31-36. |
[15] | 王迎军,赵营刚,卢玲,等.用硅烷偶联剂处理生物玻璃表面及其复合支架的制备[J].硅酸盐学报,2006,34(7):836-841.Wang Yingjun,Zhao Yinggang,Lu Ling,et al.Surface treatment of bioglass with silane coupling agent and its preparation for composite scaffolds[J].Journal of the Chinese Ceramic Society,2006,34(7):836-841. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%