血小板在原位血栓形成过程中起着重要作用.本文将血液离散为具有血浆和血小板特性的粒子,根据原位血栓的生理形成过程提出了壁面吸附的血小板与被吸附的血小板间的吸附作用力模型,使用移动粒子半隐式方法(MPS)模拟了毛细血管受损壁面处血小板聚集形成原位血栓的过程.模拟结果再现了管壁面受损处原位血栓的形成过程,结果显示原位血栓形成过程较快,且血栓一旦形成后血小板数目不再增长.对血小板的速度场进行分析,发现血小板凝聚时经历了对已凝聚血小板粒子的冲击、稳定,最后可能脱落的过程.和水平受损壁面处相比,弯曲受损壁面处原位血栓形成较慢.
参考文献
| [1] | Panteleev MA;Ananyeva NM;Ataullakhanov FI;Saenko EL .Mathematical models of blood coagulation and platelet adhesion: clinical applications.[J].Current pharmaceutical design,2007(14):1457-1467. |
| [2] | Mori D;Yano K;Tsubota K;Ishikawa T;Wada S;Yamaguchi T .Simulation of platelet adhesion and aggregation regulated by fibrinogen and von Willebrand factor.[J].Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis,2008(1):108-115. |
| [3] | Koshizuka S.;Oka Y. .MOVING-PARTICLE SEMI-IMPLICIT METHOD FOR FRAGMENTATION OF INCOMPRESSIBLE FLUID[J].Nuclear science and engineering: the journal of the American Nuclear Society,1996(3):421-434. |
| [4] | Seiichi Koshizuka;Atsushi Nobe;Yoshiaki Oka .Numerical analysis of breaking waves using the moving particle semi-implicit method[J].International Journal for Numerical Methods in Fluids,1998(7):751-769. |
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