以改性的St(o)ber方法制备二氧化硅核心颗粒,并用改性的Pechini方法在其表面沉积羟基磷灰石壳层,制备得到具有核壳结构的二氧化硅@羟基磷灰石颗粒.通过扫描电子显微镜、X射线衍射分析和红外光谱分析手段表征颗粒的物相和结构,确定颗粒的形成机制为羟基磷灰石壳层在聚乙二醇-柠檬酸作用下均匀地沉积在非晶态二氧化硅表面.含亚甲基蓝的二氧化硅@羟基磷灰石药物颗粒在磷缓冲液(pH =7.2 ～7.4)和lysosome-like缓冲液(pH=4.7)中的释放行为表明药物释放对颗粒结构和溶液的pH值非常敏感.
参考文献
| [1] | Zhang, S.;Chu, Z.;Yin, C.;Zhang, C.;Lin, G.;Li, Q. .Controllable drug release and simultaneously carrier decomposition of SiO_2-drug composite nanoparticles[J].Journal of the American Chemical Society,2013(15):5709-5716. |
| [2] | Lai CY.;Trewyn BG.;Jeftinija DM.;Jeftinija K.;Xu S.;Jeftinija S.;Lin VSY. .A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules[J].Journal of the American Chemical Society,2003(15):4451-4459. |
| [3] | Liu, JW;Jiang, XM;Ashley, C;Brinker, CJ .Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery[J].Journal of the American Chemical Society,2009(22):7567-7569. |
| [4] | Du, L;Liao, SJ;Khatib, HA;Stoddart, JF;Zink, JI .Controlled-Access Hollow Mechanized Silica Nanocontainers[J].Journal of the American Chemical Society,2009(42):15136-15142. |
| [5] | Tsyalkovsky, V.;Burtovyy, R.;Klep, V.;Lupitskyy, R.;Motornov, M.;Minko, S.;Luzinov, I. .Fluorescent nanoparticles stabilized by poly(ethylene glycol) containing shell for pH-triggered tunable aggregation in aqueous environment[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(13):10684-10692. |
| [6] | Axel Schlossbauer;Johann Kecht;Thomas Bein .Biotin-Avidin as a Protease-Responsive Cap System for Controlled Guest Release from Colloidal Mesoporous Silica[J].Angewandte Chemie,2009(17):3092-3095. |
| [7] | 韩静香,佘利娟,翟立新,刘宝春.化学沉淀法制备纳米二氧化硅[J].硅酸盐通报,2010(03):681-685. |
| [8] | Elia Martha Muzquiz-Ramos;D. A. Cortes-Hernandez;J. C. Escobedo-Bocardo;Alejandro Zugasti-Cruz;X. S. Ramirez-Gomez;J. G. Osuna-Alarcon .In vitro and in vivo biocompatibility of apatite-coated magnetite nanoparticles for cancer therapy[J].Journal of Materials Science. Materials in Medicine,2013(4):1035-1041. |
| [9] | Dembski, S.;Rupp, S.;Gellermann, C.;Batentschuk, M.;Osvet, A.;Winnacker, A. .Luminescent silicate core-shell nanoparticles: Synthesis, functionalization, optical, and structural properties[J].Journal of Colloid and Interface Science,2011(1):32-38. |
| [10] | Kong DY;Yu M;Lin CK;Liu XM;Lin J;Fang J .Sol-gel synthesis and characterization of Zn2SiO4 : Mn@SiO2 spherical core-shell particles[J].Journal of the Electrochemical Society,2005(9):H146-H151. |
| [11] | Ge, X.;Li, C.;Fan, C.;Feng, X.;Cao, B. .Enhanced photoluminescence properties of methylene blue dye encapsulated in nanosized hydroxyapatite/silica particles with core-shell structure[J].Applied physics, A. Materials science & processing,2013(3):583-589. |
| [12] | Dembski, S.;Milde, M.;Dyrba, M.;Schweizer, S.;Gellermann, C.;Klockenbring, T. .Effect of pH on the synthesis and properties of luminescent SiO _2/calcium phosphate:Eu~(3+) core-shell nanoparticles[J].Langmuir: The ACS Journal of Surfaces and Colloids,2011(23):14025-14032. |
| [13] | Liu, H.;Lu, G.;Guo, Y.;Wang, Y.;Guo, Y. .Synthesis of spherical-like Pt-MCM-41 meso-materials with high catalytic performance for hydrogenation of nitrobenzene[J].Journal of Colloid and Interface Science,2010(2):486-493. |
| [14] | Aslan K;Wu M;Lakowicz JR;Geddes CD .Fluorescent core-shell Ag@SiO2 nanocomposites for metal-enhanced fluorescence and single nanoparticle sensing platforms[J].Journal of the American Chemical Society,2007(6):1524-1525. |
| [15] | Yuandong Xu;Yanxing Qi;Gongxuan Lu .Skeletal Isomerization of n-Pentane over Platinum-Promoted Tungstophosphoric Acid Supported on MCM-41[J].Catalysis Letters,2008(1/2):83-89. |
| [16] | Nanosilicon carbide/hydroxyapatite nanocomposites: structural, mechanical and in vitro cellular properties[J].Journal of Materials Science. Materials in Medicine,2010(7):2141-2149. |
| [17] | Amaral L;Viveiros M;Molnar J .Antimicrobial activity of phenothiazines.[J].In Vivo: International Journal of In Vivo Research,2004(6):725-731. |
| [18] | Joao Paulo Tardivo;Auro Del Giglio;Carla Santos de Oliveira;Dino Santesso Gabrielli;Helena Couto Junqueira;Dayane Batista Tada;Divinomar Severino;Rozane de Fatima Turchiello;Mauricio S. Baptista .Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications[J].Photodiagnosis and photodynamics therapy,2005(3):175-191. |
| [19] | Paban,V.;Manrique,C.;Filali,M.;Maunoir-Regimbal,S.;Fauvelle,F.;Alescio-Lautier,B. .Therapeutic and preventive effects of methylene blue on Alzheimer's disease pathology in a transgenic mouse model[J].Neuropharmacology,2014(Pt.A):68-79. |
| [20] | Jian Liu;Sandy Budi Hartono;Yong Gang Jin .A facile vesicle template route to multi-shelled mesoporous silica hollow nanospheres[J].Journal of Materials Chemistry: An Interdisciplinary Journal dealing with Synthesis, Structures, Properties and Applications of Materials, Particulary Those Associated with Advanced Technology,2010(22):4595-4601. |
| [21] | Frank Roelofs;Wolfram Vogelsberger .Dissolution of Commercial Microscale Quartz Particles in Water at Biological-Like Conditions and Its Theoretical Description[J].The journal of physical chemistry, C. Nanomaterials and interfaces,2013(27):13914-13927. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%