摘要：以乳酸（D，L-LA）和L-酪氨酸（Tyr）为原料[n（D，L-LA）／n（Tyr）-95／5]，采用梯度升温法，通过直接熔融缩聚合成了系列聚（乳酸-酪氨酸）共聚物（PLA-CO-Tyr）。最佳工艺条件为压力0．095MPa，催化剂Sn（（21）。用量为0．4％（质量分数），聚合温度170℃，反应10h。用特性粘度测试、FT-IR、^1H-NMR、GPC、XRD、DSC等对其进行表征，结果表明，此方法操作简单且成本低廉，系列共聚物与PLA相比，分子链中引入了活性基团，具有较小的Tk，结晶度有所降低，并且通过控制酪氨酸的加入量可以调节聚合物的结晶度。该聚合物分子量能满足用作药物缓释试剂的要求。
The poly（lactic acid-coTL-tyrosine） copolymers （PLA-co-Tyr） were synthesized via directly melt polycondensation with lactic acid （D,L-LA） and L-tyrosine （Tyr） as raw material using linear heating method. The best synthesis conditions were pressure 0.095 MPa, catalyst dosage 0.4% （mass fraction）, polymerization tem- perature of 170℃ and polymerization time 10h. The copolymers were characterized by viscosity-average molecular weight, FT-IR, 1H-NMR, GPC, XRD and DSC. The results demonstrate that the new method with easier steps is cheaper. Compared with PLA, it has lower Tg and by controlling the amount of the tyrosine, the crys- tallinity of the copolymer can be adjusted. The copolymers could meet the demand of drug delivery carrier mate- rial.
参考文献
| [1] | Zhao YM;Wang ZY;Yang F .Characterization of poly(D,L-lactic acid) synthesized by direct melt polymerization and its application in Chinese traditional medicine compound prescription microspheres[J].Journal of Applied Polymer Science,2005(1):195-200. |
| [2] | Li, J;Zhu, BQ;Shao, YY;Liu, XR;Yang, XL;Yu, Q .Construction of anticoagulant poly (lactic acid) films via surface covalent graft of heparin-carrying microcapsules[J].Colloids and Surfaces, B. Biointerfaces,2009(1):15-19. |
| [3] | Sawyer DJ. .Bioprocessing - No longer a field of dreams[J].Macromolecular symposia,2003(0):271-281. |
| [4] | Janorkar AV;Metters AT;Hirt DE .Modification of poly(lactic acid) films: Enhanced wettability from surface-confined photografting and increased degradation rate due to an artifact of the photografting process[J].Macromolecules,2004(24):9151-9159. |
| [5] | Abe H;Tetsuka H;Doi Y .[J].Polymer Preprints(Japan),2005,5(02):5243-5247. |
| [6] | Yang Y N;Cai J;Zhuang X L et al.[J].Polymer,2010,51(12):2676-2682. |
| [7] | 董锐,郑雪琴,唐兰勤.聚乳酸-氨基酸共聚物的合成及表征[J].当代化工,2009(06):559-562. |
| [8] | Wang Z Y et al.[J].Iranian Polymer Journal,2008,17(10):791-798. |
| [9] | Zhou SB.;Deng XM.;Li XH.;Jia WX.;Liu L. .Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems[J].Journal of Applied Polymer Science,2004(3):1848-1856. |
| [10] | Wang ZY;Zhao YM;Wang F .Syntheses of poly(lactic acid)-poly(ethylene glycol) serial biodegradable polymer materials via direct melt polycondensation and their characterization[J].Journal of Applied Polymer Science,2006(1):577-587. |
| [11] | Liu Y.;Yuan ML.;Deng XM. .Study on biodegradable polymers: synthesis and characterization of poly(DL-lactic acid-co-L-lysine) random copolymer[J].European Polymer Journal,2003(5):977-983. |
| [12] | 雷自强,刘杰,王海江,路德待.酪氨酸-乳酸-乙醇酸共聚物的合成与表征[J].西北师范大学学报（自然科学版）,2010(04):70-73. |
| [13] | Wang ZY;Zhao YM;Wang F;Wang J .Syntheses of poly(lactic acid-co-glycolic acid) serial biodegradable polymer materials via direct melt polycondensation and their characterization[J].Journal of Applied Polymer Science,2006(1):244-252. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%