原位共沉淀法制备载药Fe3O4/壳聚糖磁性复合微球及其体外药物释放行为

复合材料学报, 2014, 31(1): 158-165.

原位共沉淀法制备载药Fe3O4/壳聚糖磁性复合微球及其体外药物释放行为

王旭东 ^1, , 吴鹏 ^2, , 金淑萍 ^3, , 禹兴海 ^4, , 岳国仁 ^5, , 陈进 ^6,

1.兰州第53中学,兰州,730000

2.肃南县马蹄学校,甘肃肃南,734028

3.河西学院化学化工学院,甘肃省高校河西走廊特色资源利用重点实验室,甘肃张掖734000

4.河西学院化学化工学院,甘肃省高校河西走廊特色资源利用重点实验室,甘肃张掖734000

5.河西学院化学化工学院,甘肃省高校河西走廊特色资源利用重点实验室,甘肃张掖734000

6.河西学院化学化工学院,甘肃省高校河西走廊特色资源利用重点实验室,甘肃张掖734000

关键词：磁性复合微球 , Fe3O4 , 壳聚糖 , 构象 , 药物缓释 , 靶向药物

Preparation of Fe3O4/chitosan magnetic composite particle loading drug by co-precipitation in situ and its release behavior in vitro

Keywords： magnetic composite particle , Fe3O4 , chitosan , conformational , drug controlled release , targeting drugs delivery

以核黄素为药物模型,采用原位共沉淀法制备了一种载药Fe3O4/壳聚糖复合微球.傅里叶变换红外光谱(FTIR)、透射电子显微镜(TEM)、场发射扫描电子显微镜(FESEM)和振动磁强计(VSM)表征了复合微球的化学组成、外观形貌以及磁性能.结果表明,制备的载药Fe3O4/壳聚糖复合微球平均粒径约为40 nm且粒径均匀,平均磁响应时间为52 s,饱和磁化强度为3.313 2 A·m2·kg-1.采用紫外/可见(UV/Vis)分光光度计考察了复合微球的药物包封率、载药量(质量分数),并对微球在模拟胃液、模拟肠液、生理盐水、葡萄糖溶液和二次蒸馏水中的释药行为进行跟踪.结果表明,微球的载药量可达9.9％,药物包封率为70.8％,实验条件下在模拟肠液中具有显著的缓释效果,释放10h药物累积释放16.06％,60 h达52.18％.

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