采用微弧氧化技术在钛合金表面制备钛酸钡(BaTiO3)膜；分析极化处理后的BaTiO3膜表面生物活性,并探讨其诱导羟基磷灰石形成的机理.结果表明,BaTiO3膜极化后,在模拟体液中呈现出优于BaTiO3陶瓷块体的磷灰石诱导能力,其诱导磷灰石的能力与其表面的极性、粗糙多孔的表面形态、高的比表面积以及纳米晶特征有关;微弧氧化合成BaTiO3膜的细胞毒性小于等于l级,表示其具有好的生物相容性,且高电压制备的BaTiO3膜细胞增殖率比低电压制备的高.
参考文献
| [1] | ZHANG Xiaoguang,ZHANG Yang,Preparation of titanium implant surface bioactive membrane,Journal of Clinical Rehabilitative Tissue Engineering Research,13(38),7489(2009)(张晓光,张扬,钛合金种植体表面制各的生物活性膜,中国组织工程研究与临床康复,13(38),7489(2009)) |
| [2] | YAN Jie,CAO Cong,DONG Yuqi,Methods and efficacy of surface bioactivity modification for titanium and titanium alloy,Journal of Clinical Rehabilitative Tissue Engineering Research,15(21),3921(2011)(严杰,曹聪,董宇启,钛及钛合金表面生物活性改性及效果评价,中国组织工程研究与临床康复,15(21),3921 (2011)) |
| [3] | L.H.Li,Y.M.Kong,H.W.Kim,Y.W.Kim,H.Kim,S.J.Heo,J.Y.Koak,Improved biological performance of Ti implants due to surface modification by micro-arc oxidation,Biomaterials,25(14),2867(2004) |
| [4] | L.Le Guéhennec,A.Soueidan,P.Layrolle,Y.Amouriq,Surface treatments of titanium dental implants for rapid osseointegration,Dental Materials,23(7),844(2007) |
| [5] | WANG Min,GUO Huiyong,HUANG Wenbo,LI Wenfang,ZHANG Guoge,Preparation of BaTiO3 Dielectric Film via MicroArc Oxidation and Surface Morphology of the Product,Journal of South China University of Technology(Natural Science Edition),39(11),109(2011)(王敏,郭会勇,黄文波,李文芳,张果戈,BaTiO3介电薄膜的微弧氧化制备及表面形貌,华南理工大学学报(自然科学版),39(11),109(2011)) |
| [6] | CHEN Lijin,CHEN Zhiqing,ZHANG Min,Piezoelectric ceramicA novel material for bone replacement,Journal of Biomedical Engineering,32(4),526(2001)(陈立今,陈治清,张敏,一种新型的骨修复材料_压电陶瓷,生物医学工程学杂志,32(4),526(2001)) |
| [7] | ZHU Yongfeng,WANG Liqiang,YANG Ping,QI Juning,LV Weijie,ZHANG Huo,Orthopaedic Biomechanics Meterials and Clinical Study,8(8),25(2011)(朱永锋,王立强,杨平,覃继宁,吕维洁,张获,β钛合金研究进展及其在骨科中的应用前景,生物骨科材料与临床研究,8(8),25(2011)) |
| [8] | WANG Xinhua,ZHAO Xiaoyun,Preparation of barium titanate films and its structural characterization and adhesive strength,Piezoelectrics & Acoustooptics,33(1),556(2011)(王新华,赵晓云,钛酸钡膜的制备、结构及结合强度,压电与声光,33(1),556(2011)) |
| [9] | T.Kokubo,H.Kushitani,S.Sakka,T.Kitsugi,T.Yamamuro,Solutionable to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W,Journal of Biomedical Materials Research,24(6),721 (1990) |
| [10] | SUN Shenglin,LU Yupeng,Research and Drawbacks of the Simulated Body Fluid Immersion Method in Evaluating the Biomaterials,Materials Review,25(19),96(2011)(孙圣淋,吕宇鹏,模拟体液浸泡法评价生物材料的研究与问题,材料导报,25(19),96(2011)) |
| [11] | ISO 10993-12:1996 Biological evalution of medical devices-Part 12:Sample preparation and reference materials. |
| [12] | R.R.Richardson,J.A.Miller,W.M.Reichert,Polyimides as biomaterials preliminary biocompatibility testing,Biomaterials,14(9):627(1993) |
| [13] | YAO Kangde,YIN Yuji,Biomaterials for Tissue Engineedng (Beijing,Chemical Industry Press,2003) p.87(姚康德,尹玉姬,组织工程相关生物材料(北京,化学工业出版社,2003)p.87) |
| [14] | L.L.Hench,J.Wilson.An Introduction to Bioceramics (Singapore,World Scientific Publishing Co Pte Ltd,1993) p.181 |
| [15] | L.Long,C.Y.Liu,F.Y.Zhang,L.Gao,B.Feng,Bioactivity ofmicro/nanostrutural layers on titanium surfaces,Journal of Biomedical Engineering,27(2),320(2010)(李龙,刘超宇,张富渊,高玲,冯波,钛表面微/纳米结构层的生物活性,生物医学工程杂志,27(2),320(2010)) |
| [16] | A.A.Campbell,G.E.Fryxell,J.C.Linehan,G.L.Graft,Surfaceinduced mineralization:a new method for producing calcium phosphate coatings,Journal of Biomedical Materials Research,32(1),111(1996) |
| [17] | J.P.Zhong,D.C.Greenspan,J.W.Feng.A microstructural examination of apaptite induced bioglass in vitro,Journal of Materials Science-Materials in Medicine,13(3),321(2002) |
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