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异相形核是促使蛋白质结晶最常见的途径,该途径可以降低形核势垒,比均质形核更容易实现蛋白质结晶.随着结构生物学对蛋白质结构解析需求的迅速增长,目前异相形核已经成为蛋白质结晶方法学研究领域中的热点.综述了利用材料界面诱导蛋白质晶体异相形核的研究进展,并探讨了其发展前景.

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