采用溶胶凝胶法在58S生物玻璃的基础上用氧化锌取代3mol%的氧化钙制备了含锌的生物玻璃粉体(58S3Z),对合成的粉体采用有机泡沫浸渍法在700℃及1200℃制备出58S3Z-700℃、58S3Z-1200℃玻璃及玻璃陶瓷多孔支架.在所得支架表面涂覆PLGA及PBS薄膜制备出58S3Z-1200℃-PLGA及58S3Z-1200℃-PBS复合支架.对其形貌、孔隙率、力学性能、体外降解性及细胞相容性进行了系统研究.复合后多孔支架仍然保持三维连通的多孔结构,孔隙率与复合前(86.9%±0.8%(58S3Z-700℃),80.1%±0.6%(58S3Z-1200℃))相比稍有下降,分别为75.9%土0.6%(58S3Z-1200℃-PLGA)和77.9%士0.9%(58S3Z-1200℃-PBS).但复合多孔支架显示出较高的抗压强度,分别达到1509.4kPa±162.8kPa(PLGA)和901.6 kPa±94.5kPa(PBS),与玻璃和玻璃陶瓷支架(258.4 kPa±23.6kPa)相比具有较大的提高.体外降解实验表明58S3Z-1200℃-PLGA、58S3Z-1200℃-PBS复合多孔支架可降解,经过28天的浸泡其失重率分别达到13.3%和2.1%.体外研究结果表明:58S3Z玻璃陶瓷支架复合PBS或PLGA后支持成骨细胞黏附、铺展和生长.这种新型的复合支架具有三维的网状多孔结构,良好的力学性能、降解性和细胞相容性,有望成为一种较理想的骨组织工程支架.
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