为提高复合材料的力学性能和生物活性以聚己内酯(PCL)、壳聚糖(CS)、羟基磷灰石(HA)为原料,用Hakke流变仪挤出成型制备了不同HA含量的HA/PCL-CS复合材料,并对其进行了拉伸性能的测试,考察了复合材料浸渍于模拟体液(SBF)中的生物活性及其在生理盐水中的降解性能,用X射线衍射(XRD)、傅里叶变换红外光谱(FTIR)、扫描电镜(SEM)、接触角测试仪对材料进行了表征.结果表明:复合材料的拉伸强度和断裂伸长率随HA含量的增加而降低,而杨氏模量随HA含量的增加而升高;亲水性能随着HA含量的增加而提高;HA/PCL-CS复合材料在模拟体液(SBF)中浸渍14 d后,在表面形成一层弱结晶的碳磷灰石(CHA)覆盖层,显示出良好的生物活性;PCL的分子量随着降解时间的延长而降低,溶液pH值和质量损失率却增大;浸渍28 d后,溶液pH值达到9.54,失重率达到5.86%,显示出良好的生物可降解性.
参考文献
| [1] | 卢志华,孙康宁,李爱民.羟基磷灰石复合材料的研究现状与发展趋势[J].材料导报,2003,17(S1):197-199.Lu Zhihua,Sun Kangning,Li Aimin.Hydroxyapatite composites:Current status and future directions[J].Materials Review,2003,17(S1):197-199. |
| [2] | 沈烈,乔飞,张宇强,等.碳纤维增强羟基磷灰石/聚乳酸复合生物材料的力学性能和体外降解性能[J].复合材料学报,2007,24(5):61-65.Shan Lie,Qiao Fei,Zhang Yuqiang,et al.Mechanical properties and degradation properties in vitro of carbon fiber reinforced hydroxyapatite/polylactide composite[J].Acta Materiae Compositae Sinica,2007,24(5):61-65. |
| [3] | 李世普.生物医用材料导论[M].武汉:武汉工业大学出版社,2000:84.Li Shipu.Introduction of biomedical materials[M].Wuhan:Wuhan University Press,2008:84. |
| [4] | Ducheyne P,Qiu Q.Bioactive ceramics:The effect of surface reactivity on bone formation and bone cell function[J].Biomaterials,1999,20(23/24):2287-2304. |
| [5] | 杨辉,张林,张宏,等.丝素蛋白/羟基磷灰石复合材料的制备及性能表征[J].复合材料学报,2007,24(3):141-146.Yang Hui,Zhang Lin,Zhang Hong,et al.Preparation and characterization of the silk fibroin/hydroxyapatite composite[J].Acta Materiae Compositae Sinica,2007,24(8):141-146. |
| [6] | 吕彩霞,姚子华.纳米羟基磷灰石/壳聚糖-硫酸软骨素复合材料的制备及其性能研究[J].复合材料学报,2007,24(1):110-115.Lu Caixia,Yao Zihua.Preparation and characterization of nano-hydroxyapatite/chitozan-chondroitin sulfate composite materials[J].Acta Materiae Compositae Sinica,2007,24(1):110-115. |
| [7] | 王振林,闫玉华,万涛.羟基磷灰石/胶原类骨仿生复合材料的制备及表征[J].复合材料学报,2005,22(2):83-86.Wang Zhenlin,Yan Yuhua,Wan Tao.Preparation and characterization of hydroxyapatite/collagen bone-like biomimetic composite[J].Acta Materiae Compositae Sinica,2005,22(2):83-86. |
| [8] | 张翔,李玉宝,左奕,等.加工工艺对n-HA/PA66复合材料结晶行为和力学性能的影响[J].复合材料学报,2007,24(3):72-77.Zhang Xiang,Li Yubao,Zuo Yi,et al.Effects of processing conditions on crystallinization behavior and mechanical properties of n-HA/PA66 composites[J].Acta Materiae Compositae Sinica,2007,24(3):72-77. |
| [9] | 罗平辉,赵玉涛,戴起勋,等.羟基磷灰石/聚合物可降解生物复合材料的研究进展[J].材料导报,2006,20(S2):357-361.Luo Pinghui,Zhao Yutao,Dai Qixun,et al.The research progress of biodegradable hydroxyapatite/polymer biocomposite materials[J].Materials Review,2006,20(S2):357-361. |
| [10] | 廖凯荣,卢泽俭,薄颖慧.聚乳酸/羟基磷灰石复合材料的研究Ⅱ:聚乳酸/羟基磷灰石复合材料的取向模压增强[J].中山大学学报:自然科学版,2000,39(6):59-63.Liao Kairong,Lu Zejian,Bo Yinghni.Studies of polylactide/hydroxylapatite composites Ⅱ:Enhancement of poly(DL-lactide)/hydroxylapatite composites by oriented compression molding[J].Acta Scientiarum Naturalium Universitatis Sunyatseni:Natural Science Edition,2000,39(6):59-63. |
| [11] | 杨安乐,孙康,吴人洁.聚己内醇的合成改性和应用进展[J].高分子通报,2000(2):52-57.Yang Anle,Sun Kang,Wu Renjie.Synthesis,modification and applications of poly (ε-caprolactone)[J].Chinese Polymer Bulletin,2000(2):52-57. |
| [12] | Hutmacher W,Schantz T,Zein I,et al.Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling[J].Journal of Biomedical Materials Research,2001,55(2):203-216. |
| [13] | Aihemat Yusupu,Wang Zhenbin,Zhu Liang.Application of biodegradable polycaprolactone in medicine[J].Biomedical Engineering Foreign Medical Sciences,2005,28(1):19-22. |
| [14] | Lowry K J,Hamson K R,Bear L,et al.Polycaprolactone/ glass bioabsorbable implant in a rabbit humerus fracture model[J].J Biomed Mater Res,1997,36(4):536-541. |
| [15] | 许树文,吴清基,梁金茹,等.甲壳素纺织品[M].上海:东华大学出版社,2002:21-23.Xu Shuwen,Wu Qingji,Liang Jinrn,et al.Chitin textile[M].Shanghai:Donghua University Press,2002:21-23. |
| [16] | 丁珊,李立华,周长忍.PLA/液晶复合膜的制备及其性能研究[J].生物医学工程学杂志,2002,19(3):383-385.Ding Shan,Li Lihua,Zhou Changren.Study on preparation and property of PLA/liquid crystal composite membranes[J].Journal of Biomedical Engineering,2002,19(3):383-385. |
| [17] | Ma P.Scaffolds for tissue fabrication[J].Materials Today,2004,7(5):30-40. |
| [18] | Frank A,Rath S K,Boey F,et al.Study of the initial stages of drug release from a degradable matrix of poly(D,L-lactide-co-glycolide)[J].Biomaterials,2004,25(5):813-821. |
| [19] | Cuneyt Tas A.Synthesis of biomimetic Ca hydroxyapatite powders at 37℃ in synthetic body fluids[J].Biomaterials,2000,21(14):1429-1438. |
| [20] | 宋存先,王彭延,孙洪范,等.聚己内酯在体内的降解、吸收和排泄[J].生物医学工程学杂志,2000,17(1):25-28.Song Cunxian,Wang Pengyan,Sun Hongfan,et al.The in vivo degradation,adsorption and excretion of poly (ε-caprolactone)[J].Journal of Biomedical Engineering,2000,17(1):25-28. |
| [21] | Nie Kangming,Pang Wenmin,Wang Yusong,et al.Spectral study on intermolecular coupling interaction and relation to microstructure in polyester/inorganic hybrid materials[J].Spectroscopy and Spectral Analysis,2005,25(4):537-540. |
| [22] | 王德平,于睿,黄文.生理模拟液中的磷酸钙微晶玻璃的表面变化[J].硅酸盐学报,2004,32(11):1441-1444.Wang Deping,Yu Rui,Huang Wen.Surface change of calcium phosphate glass ceramics in simulated body fluid[J].Journal of The Chinese Ceramic Society,2004,32(11):1441-1444. |
| [23] | 刘羽,钟康年,胡文云.溶胶-凝胶法合成条件与羟基磷灰石特征的关系[J].材料科学与工程,1997,15(1):63-65.Liu Yu,Zhong Kangnian,Hu Wenyun.Influences of synthetic conditions on the characteristics of hydroxyl apatite synthesised by sol-gel method[J].Materials Science and Engineering,1997,15(1):63-65. |
| [24] | 徐艺展,何丹,肖秀峰,等.羟基磷灰石/聚己内酯生物复合材料的制备及其生物活性[J].华东理工大学学报:自然科学版,2006,32(6):709-713.Xu Yizhan,He Dan,Xiao Xiufeng,et al.Preparation and bioactivity of hydroxyapatite/polycaprolacton composites[J].Journal of East China University of Science and Technology,Natural Science Edition,2006,32(6):709-713. |
| [25] | Cloing P G,Zhoung W G.The synthesis of biodegradable polymers with functional side chains[J].J Polym Sci Polym Chem,1991,24(8):17360-17365. |
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