聚乙二醇为分散剂制备纳米生物活性玻璃粉体

硅酸盐通报 , 2010, 29(2): 257-261.

聚乙二醇为分散剂制备纳米生物活性玻璃粉体

张娟娟 ^1, , 陈晓峰 ^2, , 林才 ^3, , 雷波 ^4, , 李玉莉 ^5,

1.华南理工大学生物医学工程研究院,广州,510640;教育部特种功能材料重点实验室,广州,510640

2.华南理工大学生物医学工程研究院,广州,510640;教育部特种功能材料重点实验室,广州,510640

3.华南理工大学生物医学工程研究院,广州,510640;温州医学院附属第一医院,温州,325027

4.华南理工大学生物医学工程研究院,广州,510640;教育部特种功能材料重点实验室,广州,510640

5.华南理工大学生物医学工程研究院,广州,510640;教育部特种功能材料重点实验室,广州,510640

基金项目: 浙江省自然科学基金(Y407241) 国家自然科学基金(50672028) 国家自然科学基金重点项目(50830101;50732003)

关键词：纳米粒子 , 生物活性玻璃 , 聚乙二醇 , 冷冻干燥

Preparation of Nanoscale Bioactive Glasses by Addition of PEG as Surface Dispersion Agent

采用溶胶-凝胶共沉淀方法结合冷冻干燥技术制备颗粒尺寸在纳米级的生物活性玻璃(NBG),研究了加入分散剂聚乙二醇(PEG-10000)对玻璃颗粒的分散性能、微观形貌和生物活性的影响.结果表明:没有加入PEG制得的纳米生物活性玻璃颗粒呈现不规则形态,粒径小于50 nm.加有PEG的玻璃颗粒形状趋于规则的球形,分散性大大提高,颗粒粒径在40～100 nm,而且加入PEG的浓度越高,制备的颗粒粒径越小.通过比较纳米级的生物活性玻璃与溶胶-凝胶生物活性玻璃在模拟人体体液(SBF)中的表面矿化研究,发现纳米生物活性玻璃比溶胶-凝胶生物活性玻璃有更高的生物活性.

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