采用注射成型法制备了羟基磷灰石/聚酰胺6(HA/PA6)多孔支架,用SEM、XRD、DSC等手段表征了支架的组成结构和形貌,检测了其力学性能.研究表明,调节羟基磷灰石(HA)含量、偶氮二甲酰胺(AC)用量和预塑量能有效控制支架的力学性能、孔径大小和孔隙率.HA/PA6支架的孔径在100~500μm左右,孔隙率达到甚至超过65%,压缩模量和压缩强度达到或超过人体骨小梁,并接近人体松质骨的压缩性能,基本能够同时满足支架对力学性能和孔结构的要求.与多孔支架的常规制备方法比较,提供了一种快速便利的制备多孔支架的技术方法.
参考文献
[1] | Boyana B D;Hummert T W;Dean D D et al.[J].Biomaterials,1996,17:137-146. |
[2] | Yu Haiying;Matthew H W;Wooley P H et al.[J].JBiomed Mater Res B:Appl Biomater,2008,3:541-547. |
[3] | Karageorgiou V;Kaplan D .Porosity of 3D biornaterial scaffolds and osteogenesis[J].Biomaterials,2005(27):5474-5491. |
[4] | Rezwan K;Chen QZ;Blaker JJ;Boccaccini AR .Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering.[J].Biomaterials,2006(18):3413-3431. |
[5] | Bledzki AK;Faruk O .Effects of the chemical foaming agents, injection parameters, and melt-flow index on the microstructure and mechanical properties of microcellular injection-molded wood-fiber/polypropylene composites[J].Journal of Applied Polymer Science,2005(3):1090-1096. |
[6] | Guo Mingeheng;Heuzey M C;Carreau P J .[J].Polymer Engineering and Science,2007,47:1070-1081. |
[7] | Yuan Mingjun;Turng L S .[J].Polymer,2005,46:7273-7292. |
[8] | Chandra A;Gong Shaoqin;Yuan Mingjun et al.[J].Polymer Engineering and Science,2005,45:52-61. |
[9] | Gomes ME;Ribeiro AS;Malafaya PB;Reis RL;Cunha AM .A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour.[J].Biomaterials,2001(9):883-889. |
[10] | Wei Jie;Li Yubao .[J].European Polymer Journal,2004,40:509-515. |
[11] | Lin A S P;Barrows T H;Cartmell S H et al.[J].Biomaterials,2003,24:481-489. |
[12] | Zhang Xiang;Li Yubaoi;Zuo Yi et al.[J].Composites Part A:Applied Science and Manufacturing,2007,38:843-848. |
[13] | Yuan Mingjun;Trung L S .[J].Polymer Engineering and Science,2006,53:904-918. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%