以乙酰乙酸乙酯和尿素为原料,用对甲苯磺酸作催化剂合成6-甲基尿嘧啶,探讨了不同相转移催化剂、带水剂、相转移催化剂用量及脱水缩合时间等因素对反应产物产率的影响。得出最佳工艺条件为：19．8mL乙酰乙酸乙酯、10g尿素,对甲苯磺酸1．2g,150mL石油醚作带水剂,0．3g聚乙二醇200作相转移催化剂,回流脱水缩合8h,产率可达78%。
6-meyhyl uracil was synthesized from ethyl acetoacetate and urea with p-toluenesulfonic acid as cata-lyst. The effects of phase transfer catalysts, water-carrying agents, amount of phase transfer catalyst and reaction time on yield of 6-meyhyl uracil were studied. The optimum conditions were as follows:fixed ratio of raw materials n(urea) ∶ n(ethylacetoacetate) =0. 167mol ∶0. 157mol =1. 06 ∶1,the amount of p-toluenesulfonic acid 1. 2g;150 mL petroleum ether as water-carrying agent;0. 3 g polyethylene glycol 200 as phase transfer catalyst;reaction time 8h;and reaction temperature 72℃,the yield of 6-meyhyl uracil was 78%.
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