采用微弧氧化法在医用钛表面制备羟基磷灰石(HA)/壳聚糖(CS)涂层.通过扫描电镜(SEM)、X射线衍射(XRD)仪、红外光谱(FTIR)仪分析涂层的形貌和物相,评价HA/CS涂层对成骨细胞的毒性及其在动物体内的生物活性,分析微弧氧化法制备钛基HA/CS涂层的特征及其在骨修复中应用的可能性.结果表明:微弧氧化法可在钛表面生成HA/CS涂层,厚度40±2 μm、粗糙度3.3±0.1 μm、孔隙率(30±2)％,孔隙近圆形、直径几微米到20 μm,结合强度20.5±1.1 MPa;涂层中HA与CS之间没有形成化学键,晶体HA占10％,平均粒径37 nm,非晶体HA占90％;钛基HA/CS涂层材料对成骨细胞增殖具有促进作用,无细胞毒性,在动物体内能够诱导骨小梁形成,具有高的生物活性.微弧氧化法制备的高生物活性钛基HA/CS涂层材料,在骨修复方面具有良好的应用前景.
参考文献
| [1] | Hacking SA;Tanzer M;Harvey EJ;Krygier JJ;Bobyn JD .Relative contributions of chemistry and topography to the osseointegration of hydroxyapatite coatings.[J].Clinical Orthopaedics and Related Research,2002(405):24-38. |
| [2] | Zhang Yuanyuan;Tao Jie;Pang Yingchun et al.[J].Rare Metal Materials and Engineering(稀有金属材料与工程),2006,35(03):459. |
| [3] | Xu Xiaoyan;Liu Taotao;Zheng Jun et al.[J].Materials Review(材料导报),2012,26(08):102. |
| [4] | Shao Zhongcai;Jiang Haitao;Wang Shuang .[J].Rare Metal Materials and Engineering(稀有金属材料与工程),2012,41(z2):586. |
| [5] | Chesnutt B M;Yuan Y;Buddington K et al.[J].Tissue Engineering Part A,2009,15(09):2571. |
| [6] | Pang X;Zhitomirsky I .[J].Materials Characterization,2007,58(04):339. |
| [7] | Redepenning J;Venkataraman G;Chen J et al.[J].Journal of Biomedical Materials Research,2003,66A(02):411. |
| [8] | Wang J;van Apeldoorn A;de Groot K .Electrolytic deposition of calcium phosphate/chitosan coating on titanium alloy: growth kinetics and influence of current density, acetic acid, and chitosan.[J].Journal of biomedical materials research, Part A,2006(3):503-511. |
| [9] | Chen J;Shi Y;Wang L et al.[J].Materials Letters,2006,60(20):2538. |
| [10] | Liu Rongfang;Xiao Xiufeng;Xu Daoxuan .[J].Journal of the Chinese Ceramic Society(硅酸盐学报),2003,31(06):615. |
| [11] | Li Xiaofeng;Zhao Jinmin;Su Wei et al.[J].Journal of Clinical Rehabilitative Tissue Engineering Research(中国组织工程研究与临床康复),2011,15(06):990. |
| [12] | Wang Jiang;LiYubao;Zuo Yi et al.[J].Journal of Functional Materials(功能材料),2008,39(10):171. |
| [13] | Khairouna I;Driessens F C M;Boltonga M G et al.[J].BIOMATERIALS,1999,20(04):393. |
| [14] | Akay G;Birch MA;Bokhari MA .Microcellular polyHIPE polymer supports osteoblast growth and bone formation in vitro.[J].Biomaterials,2004(18):3991-4000. |
| [15] | Garcia T;Roman-Roman S;Jackson A et al.[J].BONE,2002,31(01):205. |
| [16] | Ishaug S L;Crane G M;Miller M J et al.[J].Journal of Biomedical Materials Research,1997,36(01):17. |
| [17] | Roodman G D .[J].Endocrine Reviews,1996,17(04):308. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%