分别以氨基聚乙二醇(PEG-NH2)和氨基聚乙二醇单甲醚(MPEG-NH2)为大分子引发剂,制备了三嵌段(ABA)和两嵌段(AB)的聚L-丙氨酸-聚乙二醇嵌段共聚物;利用圆二色光谱(CD)研究了共聚物在溶液中的二级结构及其影响因素.结果表明,在水溶液中嵌段共聚物主链主要以α-螺旋构象存在;在一定范围内,α-螺旋含量随共聚物溶液浓度的增大而增大,随溶液离子强度的增大而降低;相同条件下,AB型共聚物在溶液中的α-螺旋含量比ABA型共聚物高.
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