在AZ81镁合金表面制备了抗腐蚀和药物释放复合涂层,并对其耐蚀性、药物释放性能及生物相容性进行研究.DSC和红外光谱数据表明,紫杉醇均匀分散在PLGA体系中.药物释放数据表明30d后,药物释放率在80％左右.SEM、电化学阻抗、极化及镁离子释放数据表明,PLLA涂层通过有效填充微弧氧化膜表面的微孔与裂缝提高了镁合金的耐腐蚀性.血液和细胞实验表明涂层镁合金血液相容性良好,无细胞毒性.
参考文献
| [1] | 胡涛,于振涛,周廉,介万奇,周景昱,王海昌.医用316L不锈钢支架表面磁性膜对血管内皮化的影响[J].稀有金属材料与工程,2009(09):1552-1555. |
| [2] | 马波,王克光,李争显,周廉,程何祥.钛表面沉积Fe-Pd磁性薄膜的研究[J].稀有金属材料与工程,2005(08):1341-1344. |
| [3] | 逯平,方铭中,曹路,许鑫华.不同镁合金支架材料MAO/PLLA复合膜研究[J].稀有金属材料与工程,2011(12):2232-2235. |
| [4] | O'Brien B;Carroll W .The evolution of cardiovascular stent materials and surfaces in response to clinical drivers: a review.[J].Acta biomaterialia,2009(4):945-958. |
| [5] | Kukreja N;Onuma Y;Daemen J;Serruys PW .The future of drug-eluting stents.[J].Pharmacological research: The official journal of The Italian Pharmacological Society,2008(3):171-180. |
| [6] | Farb A;Heller PF;Shroff S;Cheng L;Kolodgie FD;Carter AJ;Scott DS;Froehlich J;Virmani R .Pathological analysis of local delivery of paclitaxel via a polymer-coated stent.[J].Circulation: An Official Journal of the American Heart Association,2001(4):473-479. |
| [7] | 黄晶晶,任伊宾,张炳春,杨柯.镁及镁合金的生物相容性研究[J].稀有金属材料与工程,2007(06):1102-1105. |
| [8] | Serre CM;Papillard M;Chavassieux P;Voegel JC;Boivin G .Influence of magnesium substitution on a collagen-apatite biomaterial on the production of a calcifying matrix by human osteoblasts.[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(4):626-633. |
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