为了增强海藻酸钠凝胶的稳定性以及对药物的缓释效果,将海藻酸钠用聚乙二醇(PEG200)交联,在水溶液中用对甲苯磺酸催化、经过酯化反应合成了共价交联的海藻酸钠凝胶;通过红外光谱、热重分析和X-射线分析对产物进行了表征.与钙离子交联的海藻酸钠凝胶相比,共价交联海藻酸凝胶在仿生体液中结构稳定,在模拟体液中完全降解时间持续到60天.凝胶对牛血清白蛋白的载药率达到11.5％,显示出明显的缓释效应和pH响应性能,具有作为pH控释和缓释药物载体的应用前景.
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