利用N-异丙基丙烯酰胺(NIPA)以及N-乙基丙烯酰胺(EA)两种单体合成了温敏型线性共聚物P(NIPA-co-EA),并用核磁共振氢谱、红外光谱以及凝胶渗透色谱(GPC)对该聚合物的结构进行了表征.采用浊度观察法和分光光度法两种方法分别对聚合物的LCST值进行了测试研究,探讨了通过调节两种单体的组分比例来调控体系的LCST值,并讨论了外添加剂NaCl以及BSA对线性聚合物P(NIPA-co-EA)LCST的影响.结果表明,随着EA单体摩尔配比的增大,对应共聚物的LCST值也相应增大,且在32～41.6℃之间可调.向P(NIPA-co-EA)水溶液中加入NaC1,当NaCl的量由0.9％(质量分数)增加到2％(质量分数)时,共聚物的LCST值从34.3℃降为31.6℃；加入BSA,线性共聚物的LCST随BSA浓度的增加而增加,且当EA10水溶液中加入20mg/mLBSA时,线性共聚物P(NIPA-co-EA)的LCST可高达38.9℃.
参考文献
| [1] | Zakir M.O.Rzaev;Sevil Dincer;Erhan Piskin .Functional copolymers of N-isopropylacrylamide for bioengineering applications[J].Progress in Polymer Science,2007(5):534-595. |
| [2] | 李智慧,刘文涛,李中原,张鸿儒,杨明成,何素芹,朱诚身.PNIPA/PEG多孔智能水凝胶的辐射合成与性能研究[J].功能材料,2009(12):2047-2049,2057. |
| [3] | Comolli N;Neuhuber B;Fischer I .In vitro analysis of PNIPAAm-PEG, a novel, injectable scaffold for spinal cord repair.[J].Acta biomaterialia,2009(4):1046-1055. |
| [4] | Reddy, TT;Takahara, A .Simultaneous and sequential micro-porous semi-interpenetrating polymer network hydrogel films for drug delivery and wound dressing applications[J].Polymer: The International Journal for the Science and Technology of Polymers,2009(15):3537-3546. |
| [5] | Liu L;Sheardown H .Glucose permeable poly (dimethyl siloxane) poly (N-isopropyl acrylamide) interpenetrating networks as ophthalmic biomaterials.[J].Biomaterials,2005(3):233-244. |
| [6] | Li P;Xie R;Jiang J et al.Thermo-responsive gating membranes with controllable length and density of poly (N-isopropylacrylamide) chains grafted by ATRP method[J].Journal of Membrane Science,2009,337(1-2):310-317. |
| [7] | Soo Young Park;Sun Hang Cho;Soon Hong Yuk;Mu Shik Jhon .Characterization of temperature-induced phase transition of polymer complex composed of poly-(N,N-dimethylamino)ethyl methacrylate and poly(ethylacrylamide) by ~1H-NMR relaxation time measurement[J].European Polymer Journal,2001(9):1785-1790. |
| [8] | Lowe JS.;Parsonage JR.;Snowden MJ.;Chowdhry BZ. .The preparation and physico-chemical properties of poly(N-ethylacrylamide) microgels[J].Polymer: The International Journal for the Science and Technology of Polymers,1998(5):1207-1212. |
| [9] | Weijun Ye;Joseph M.DeSimone .Emulsion Polymerization of N-Ethylacrylamide in Supercritical Carbon Dioxide[J].Macromolecules,2005(6):2180-2190. |
| [10] | Wensheng Cai;Ram B. Gupta .Poly(N-ethylacrylamide) Hydrogels for Lignin Separation[J].Industrial & Engineering Chemistry Research,2001(15):3406-3412. |
| [11] | Xue W.;Huglin MB.;Jones TGJ. .Parameters affecting the lower critical solution temperature of linear and crosslinked poly(N-ethylacrylamide) in aqueous media[J].Macromolecular chemistry and physics,2003(16):1956-1965. |
| [12] | Housni A;Narain R .Aqueous solution behavior of p(N-isopropyl acrylamide) in the presence of water-soluble macromolecular species[J].European Polymer Journal,2007(10):4344-4354. |
| [13] | Alem, H;Jonas, AM;Demoustier-Champagne, S .Poly(N-isopropylacrylamide) grafted into nanopores: Thermo-responsive behaviour in the presence of different salts[J].Polymer Degradation and Stability,2010(3):327-331. |
| [14] | Bunsow J;Johannsminn D .Electrochemically produced responsive hydrogel films: Influence of added salt on thickness and morphology[J].Journal of Colloid and Interface Science,2008(1):61-65. |
| [15] | Fundueanu G;Constantin M;Ascenzi P .Preparation and characterization of pH- and temperature-sensitive pullulan microspheres for controlled release of drugs.[J].Biomaterials,2008(18):2767-2775. |
| [16] | H. Y. Liu;X. X. Zhu .Lower critical solution temperatures of N-substituted acrylamide copolymers in aqueous solutions[J].Polymer: The International Journal for the Science and Technology of Polymers,1999(25):6985-6990. |
| [17] | Idziak I.;Lessard D.;Gravel D.;Zhu X.X.;Avoce D. .Thermosensitivity of aqueous solutions of poly(N,N-diethylacrylamide)[J].Macromolecules,1999(4):1260-1263. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%