利用可降解聚合物微球的相互粘结制备了一种新型的组织工程支架材料,可用于软骨和软骨下骨损伤的修复.采用光学显微镜、扫描电镜对支架的表面形貌、内部结构进行了表征,同时研究了支架材料的力学性能.此外还研究了微球的粒径对支架材料孔隙率的影响.结果显示,该材料在结构上分为乳酸-羟基乙酸共聚物(PLGA)层和PLGA/生物活性玻璃(BG)层;材料的孔隙三维连通、分布均匀;采用粒径为150～200 μm微球所制备的支架孔隙率为(53.37±4.39)%,在10%的应变下材料压缩强度便已达到了0.9 MPa,显示了较强的力学性能;随着微球粒径的变小,材料孔隙率逐渐增大.这种微球支架在骨-软骨组织缺损修复方面有着很大的研究价值和应用价值.
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