支架内再狭窄多年来一直是制约冠心病介入治疗远期疗效的瓶颈,药物洗脱支架的出现为解决这一问题提供了有效手段,而药物洗脱支架制备的关键在于载药层的制备.针对载药层制备技术,包括支架的预处理、载药材料的选择、载药层的制备工艺以及载药层药物的释放机制进行了回顾与综合评述,并指出了药物洗脱支架栽药层材料及其制备技术的发展方向.
参考文献
| [1] | Landau C;Lange R A;Hilis L D .Percutaneous transluminal coronary angioplasty[J].New England Journal of Medicine,1994,330(14):981. |
| [2] | Mintz G S;Popma J J;Pichard A D et al.Arterial remodeling after coronary angioplasty:a serial intravascular ultrasound study[J].Circulation,1996,94(01):35. |
| [3] | Hoffmann R;Mintz G S;Dussaillant G R et al.Patterns and mechanisms of in-stent restenosis.A serial intravascular ultrasound study[J].Circulation,1996,94(06):1247. |
| [4] | Schwartz R S;Edelman E R;Carter A et al.Preclinical evaluation of drug-eluting stents for peripheral applications[J].Circulation,2004,110:2498. |
| [5] | Tepe G;Schmehl J;Wendel HP;Schaffner S;Heller S;Gianotti M;Claussen CD;Duda SH .Reduced thrombogenicity of nitinol stents - In vitro evaluation of different surface modifications and coatings[J].Biomaterials,2006(4):643-650. |
| [6] | 肖梅,毛福明,凌一鸣.低温等离子体对血管内金属支架的表面改性[J].真空科学与技术学报,2003(03):182-186. |
| [7] | Finkelstein A;Mcclean D;Kar S et al.Local drug delivery via a coronary stent with programmable release pharmacokinetics[J].Circulation,2003,107:777. |
| [8] | Winslow RD;Sharma SK;Kim MC .Restenosis and drug-eluting stents.[J].The Mount Sinai journal of medicine,2005(2):81-89. |
| [9] | Ong AT;Serruys PW .Technology Insight: an overview of research in drug-eluting stents.[J].Nature clinical practice. Cardiovascular medicine,2005(12):647-658. |
| [10] | Regar E;Sianos G;Serruys P W .Stent development and local drug delivery[J].British Medical Bulletin,2001,59:227. |
| [11] | Wieneke H;Sawitowski T;Wnendt S et al.Keramische nanobesehichtung von koronaren stents zur reduktion der neointimalen proliferation[J].Catheterization and Cardiovascular Interventions,2003,60:399. |
| [12] | Morice MC;Serruys PW;Sousa JE;Fajadet J;Ban Hayashi E;Perin M;Colombo A;Schuler G;Barragan P;Guagliumi G;Molnar F;Falotico R .A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization.[J].The New England journal of medicine,2002(23):1773-1780. |
| [13] | Kamath KR;Barry JJ;Miller KM .The Taxus drug-eluting stent: a new paradigm in controlled drug delivery.[J].Advanced drug delivery reviews,2006(3):412-436. |
| [14] | Sousa J E;Serruys P W;Costa M A .New frontiers in cardiology Drug-eluting stents:part 1[J].Circulation,2003,107:2274. |
| [15] | Vogt F;Stein A;Rettemeier G et al.Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent[J].European Heart Journal,2004,25:1330. |
| [16] | Thierry B;Merhi Y;Silver J;Tabrizian M .Biodegradable membrane-covered stent from chitosan-based polymers.[J].Journal of biomedical materials research, Part A,2005(3):556-566. |
| [17] | Chen MC;Liang HF;Chiu YL;Chang Y;Wei HJ;Sung HW .A novel drug-eluting stent spray-coated with multi-layers of collagen and sirolimus[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2005(1):178-189. |
| [18] | Farb A;Heller PF;Shroff S;Cheng L;Kolodgie FD;Carter AJ;Scott DS;Froehlich J;Virmani R .Pathological analysis of local delivery of paclitaxel via a polymer-coated stent.[J].Circulation: An Official Journal of the American Heart Association,2001(4):473-479. |
| [19] | 酱振军;曾敏;谢志勇 等.一种具有防再狭窄涂层的血管支架[P].CN 001372076,2002-07-31. |
| [20] | Acharya G;Park K .Mechanisms of controlled drug release from drug-eluting stents.[J].Advanced drug delivery reviews,2006(3):387-401. |
| [21] | Domb A J .Eleetropolymerizable monomers and polymeric coating on implantable devices[P].WO 0139813,2001-06-07. |
| [22] | Thierry B;Winnik F M;Merhi Y et al.Bioactive coatings of endovascular stents based on polyelectrolyte multilayers[J].Biomacromolecules,2003,4(06):1564. |
| [23] | Heldman AW;Cheng L;Jenkins GM;Heller PF;Kim DW;Ware M Jr;Nater C;Hruban RH;Rezai B;Abella BS;Bunge KE;Kinsella JL;Sollott SJ;Lakatta EG;Brinker JA;Hunter WL;Froehlich JP .Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis.[J].Circulation: An Official Journal of the American Heart Association,2001(18):2289-2295. |
| [24] | Bartorelli AL;Trabattoni D;Fabbiocchi F;Montorsi P;de Martini S;Calligaris G;Teruzzi G;Galli S;Ravagnani P .Synergy of passive coating and targeted drug delivery: the tacrolimus-eluting Janus CarboStent.[J].Journal of interventional cardiology,2003(6):499-505. |
| [25] | Whelan D M;Giessen W J V D;Krabbendam S C et al.Biocompatibility of phosphorylcholine coated stents in normal porcine coronary arteried[J].Heart Drug,2000,83:338. |
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