将β-环糊精、环氧氯丙烷和氯化胆碱经一步缩聚反应制得阳离子环糊精聚合物（CPβCD）,采用反相悬浮法制备壳聚糖微球（CS）,再以环氧氯丙烷为交联剂制备具有CPβCD和CS双重特性的壳聚糖固载阳离子环糊精聚合物微球（CS/CPβCD）,用核磁共振（1H-NMR）,红外光谱（FT-IR）,扫描电镜（SEM）和X射线衍射（XRD）对产物进行表征,以酮洛芬为模型药物,研究了CS/CPβCD微球的载药性能。结果表明,CS/CPβCD微球对酮洛芬的最大载药量为849.4 mg/g,吸附规律符合Freundlich等温方程,载药CS/CPβCD微球具有缓释性能,并且在模拟肠液中的缓释效果优于模拟胃液,为CS/CPβCD作为药物缓释载体提供了依据。
Cationicβ-cyclodextrin polymer（CPβCD） was synthesized by a one-step condensation ofβ-cyclodextrin,epoxychoropropane,and choline chloride.The as-prepared CPβCD was then cross-linked with chitosan microspheres prepared via an inverse phase suspension method using epichlorohydrin as the cross-linking agent to obtain chitosan bearing cationicβ-cyclodextrin polymer（CS/CPβCD）.The structures of the products were characterized by1Hnucle- ar magnetic resonance spectrum（1H-NMR）,Fourier transform infrared spectrum（FT-IR）,X-ray diffraction（XRD） and scanning electron microscope（SEM）.Drug performance was studied using ketoprofen as a model drug.The ex- perimental results indicated that the maximum drug-loading capacity of CS/CPβCD to ketoprofen was 849.4 mg/g,the adsorption equilibrium was fitted to Freundlich equation.The release of ketoprofen from CS/CPβCD microspheres was pH-sensitive.Fast release occurred in simulated gastric fiuid（pH1.2）,while the release was slow in simulated intestinal fluid（pH 7.4）.The research provides the basis of drug-loading performances of CS/CPβCD.
参考文献
| [1] | 曹佐英,张启修,魏琦峰.微波辐射下交联壳聚糖树脂固载化β-环糊精[J].高分子材料科学与工程,2003(03):204-207. |
| [2] | 黄岚,辛剑宇,张楠,李建树.阳离子β-环糊精聚合物复合胰岛素的海藻酸钠/壳聚糖载药微球[J].中国组织工程研究与临床康复,2009(08):1481-1485. |
| [3] | 胡智文,郑世睿,万军民,高磊,温会涛,陈文兴.纤维素纤维接枝β-环糊精预聚体的制备及包结性能[J].高分子材料科学与工程,2008(01):39-43. |
| [4] | M. Prabaharan;R. Jayakumar .Chitosan-graft-β-cyclodextrin scaffolds with controlled drug release capability for tissue engineering applications[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2009(4):320-325. |
| [5] | Prabaharan M;Mano JF .Hydroxypropyl chitosan bearing beta-cyclodextrin cavities: Synthesis and slow release of its inclusion complex with a model hydrophobic drug[J].Macromolecular bioscience,2005(10):965-973. |
- 下载量()
- 访问量()
- 您的评分：
-
10%
-
20%
-
30%
-
40%
-
50%