欢迎登录材料期刊网

材料期刊网

高级检索

为合成新的铂配合物顺式-没食子酸-氨,2-甲基吡啶合铂(Ⅱ),以氯亚铂酸钾为起始原料,先后与碘化钾、2-甲基吡啶、氨水、硝酸银和没食子酸反应合成目标化合物.采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构,利用MTT体外检测法进行了初步的体外活性评价.结果显示合成的化合物结构与理论值一致,具有一定的体外肿瘤生长抑制活性.

参考文献

[1] Holford J;Beale P J;Boxall F E et al.Mechanisms of drug resistance to the platinum complex ZD0473 in ovarian cancer cell lines[J].European Journal of Cancer,2000,36(15):1984-1990.
[2] Kim YS;Song R;Chung HC;Jun MJ;Sohn YS .Coordination modes vs. antitumor activity: synthesis and antitumor activity of novel platinum(II) complexes of N-substituted amino dicarboxylic acids[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2004(1):98-104.
[3] Furin A;Guiotto A;Baccichetti F;Pasut G;Deuschel C;Bertani R;Veronese FM .Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates.[J].European Journal of Medicinal Chemistry: Chimie Therapeutique,2003(7/8):739-749.
[4] Moradell S.;Lorenzo J.;Rovira A.;Robillard MS.;Aviles FX.;Moreno V. de Llorens R.;Martinez MA.;Reedijk J.;Llobet A. .Platinum complexes of diaminocarboxylic acids and their ethyl ester derivatives: the effect of the chelate ring size on antitumor activity and interactions with GMP and DNA[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2003(4):493-502.
[5] Galanski M;Slaby S;Jakupec M A et al.Synthesis,characterization,and in vitro antitumor activity of osteotropic diam(m)ineplatinum(Ⅱ) complexes bearing a N,N-bis(phosphonomethyl) glycine ligand[J].Journal of Medicinal Chemistry,2003,46(23):4946-4951.
[6] Mikata Y;Shinohara Y;Yoneda K;Nakamura Y;Brudzinska I;Tanase T;Kitayama T;Takagi R;Okamoto T;Kinoshita I;Doe M;Orvig C;Yano S .Unprecedented sugar-dependent in vivo antitumor activity of carbohydrate-pendant cis-diamminedichloroplatinum(II) complexes.[J].Bioorganic and Medicinal Chemistry Letters,2001(23):3045-3047.
[7] Criado J J;Dominguez M F;Medarde M et al.Structural characterization,kinetic studies,and in vitro biological activity of new cis-diamminebis-cholyl-glycinate(O,O')-Pt(Ⅱ) and cis-diamminebis-ursodeoxycholate(O,O')-Pt(Ⅱ)complexes[J].Bioconjugate Chemistry,2000,11(02):167-174.
[8] Kushev D;Gorneva G;Enchev V;Naydenova E;Popova J;Taxirov S .Synthesis, cytotoxicity, antibacterial and antitumor activity of platinum(II) complexes of 3-aminocyclohexanespiro-5-hydantoin[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2002(3/4):203-211.
[9] Bakalova A;Buyukliev R;Tcholakova I;Momekov G;Konstantinov S;Karaivanova M .Synthesis, physicochemical investigation and cytotoxic activity of new Pt(II) complexes with hydantoin ligands.[J].European Journal of Medicinal Chemistry: Chimie Therapeutique,2003(6):627-632.
[10] 王联红,刘芸,袁阜平,尤启冬,苟少华.1R,35-1,2,2-三甲基-1,3-环戊二胺为配体的铂(Ⅱ)配合物的合成、表征和抗肿瘤活性[J].无机化学学报,2004(07):775-780.
[11] Kim YS;Kim KM;Song R;Jun MJ;Sohn YS .Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates[J].Journal of Inorganic Biochemistry: An Interdisciplinary Journal,2001(3):157-163.
[12] 李沐涵,殷美琦,冯靖涵,王明艳.没食子酸抗肿瘤作用研究进展[J].中医药信息,2011(01):109-111.
[13] 何文飞,何大维,马超,赵丹,张永波,卞则栋.没食子酸抑制人神经母细胞瘤增殖作用的实验研究[J].第三军医大学学报,2011(02):107-110.
[14] 郑曙明,黄建军,吴青,沙莎.复方五倍子有效成分的分离鉴定及抑菌活性研究[J].水生生物学报,2010(01):57-64.
[15] 汤为学;骆云鹏;王瑞雪 .人实体瘤抗癌药物敏感试验MTT法的建立[J].重庆医科大学学报,1992,20(02):40-42.
[16] 贾木欣,曲雯雯,陈光巨,刘若庄.铂类抗肿瘤药物ZD0473与双链及单链DNA作用差异的理论研究[J].高等学校化学学报,2004(08):1481-1484.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
文章评分
  • 您的评分:
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%