根据海藻酸钠作为药物载体材料的改性方法不同,分析了近几年国内外的研究成果,主要阐述了海藻酸钠的共混改性和化学改性及各自的载药性能,分析了改性材料在药物载体领域的应用上存在的优势与不足,并展望了海藻酸钠的改性方法及应用.
参考文献
| [1] | Ji-Sheng Yang;Ying-Jian Xie;Wen He .Research progress on chemical modification of alginate: A review[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(1):33-39. |
| [2] | 张连飞,宋淑亮,梁浩,吉爱国.海藻酸钠接枝聚合物研究进展[J].中国生化药物杂志,2009(04):281-284. |
| [3] | Matricardi P;Meo CD;Coviello T;Alhaique F .Recent advances and perspectives on coated alginate microspheres for modified drug delivery.[J].Expert opinion on drug delivery,2008(4):417-425. |
| [4] | Yun Sik Nam;Min Soo Bae;Sungwon Kim .Mechanism of Albumin Release from Alginate and Chitosan Beads Fabricated in Dual Layers[J].Macromolecular Research,2011(5):476-482. |
| [5] | 刘源岗,王士斌,王莹.海藻酸钙-聚精氨酸聚电解质微胶囊强度性能研究[J].功能材料,2009(01):119-122. |
| [6] | Leick, S.;Kemper, A.;Rehage, H. .Alginate/poly-l-lysine capsules: Mechanical properties and drug release characteristics[J].Soft matter,2011(14):6684-6694. |
| [7] | 王健,邱丽媛,张文君,段翠密,郝彤,林秋霞,王常勇.多聚鸟氨酸海藻酸钡微囊物理性能和生物相容性研究[J].中国康复理论与实践,2010(06):522-524,封3. |
| [8] | Tam SK;Bilodeau S;Dusseault J;Langlois G;Halle JP;Yahia LH .Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules.[J].Acta biomaterialia,2011(4):1683-1692. |
| [9] | Zhang YJ;Wei Q;Yi CB;Hu CY;Zhao WF;Zhao CS .Preparation of Polyethersulfone-Alginate Microcapsules for Controlled Release[J].Journal of Applied Polymer Science,2009(2):651-657. |
| [10] | Marcia Regina de Moura;Fauze Ahmad Aouada;Silvia Luciana Favaro;Eduardo Radovanovic;Adley Forti Rubira;Edvani C. Muniz .Release of BSA from porous matrices constituted of alginate-Ca2± andPNIPAAm-interpenetrated networks[J].Materials science & engineering, C. Biomimetic and supramolecular systems,2009(8):2319-2325. |
| [11] | 郝晓丽 .海藻酸钙冻干膜及海藻酸钙基互穿网络膜材料的制备与性能研究[D].青岛大学,2010. |
| [12] | 英晓光,张凤菊,张立广,成国祥.互穿网络改性的蛋白质印迹海藻酸钙微球的制备与表征[J].天津大学学报,2011(02):134-140. |
| [13] | Yang SJ;Lin FH;Tsai HM;Lin CF;Chin HC;Wong JM;Shieh MJ .Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms.[J].Biomaterials,2011(8):2174-2182. |
| [14] | Finotelli P V;Da Silva D;Sola-Penna M et al.Microcapsules of alginate/chitosan containing magnetic nanoparticles for conrolled release of insulin[J].Colloids and Surfaces B:Biointerfaces,2010,81(01):206. |
| [15] | 宋策,张阳德,于丽,陈璐,于洪梅.乳糖化修饰海藻酸钠-多聚赖氨酸纳米粒的制备及其肝靶向性研究[J].中国现代医学杂志,2008(22):3269-3272. |
| [16] | Josef E;Zilberman M;Bianco Peled H .Composite alginate hydrogels: An innovative approach for the controlled release of hydrophobic drugs.[J].Acta biomaterialia,2010(12):4642-4649. |
| [17] | Li, Y.;MacIel, D.;Tomás, H.;Rodrigues, J.;Ma, H.;Shi, X. .PH sensitive Laponite/alginate hybrid hydrogels: Swelling behaviour and release mechanism[J].Soft matter,2011(13):6231-6238. |
| [18] | Karewicz A;Zasada K;Szczubialka K;Zapotoczny S;Lach R;Nowakowska M ."Smart" alginate-hydroxypropylcellulose microbeads for controlled release of heparin.[J].International Journal of Pharmaceutics,2010(1/2):163-169. |
| [19] | Qun Wang;Xianwen Hu;Yumin Du .Alginate/starch blend fibers and their properties for drug controlled release[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2010(3):842-847. |
| [20] | Lin, N.;Huang, J.;Chang, P.R.;Feng, L.;Yu, J. .Effect of polysaccharide nanocrystals on structure, properties, and drug release kinetics of alginate-based microspheres[J].Colloids and Surfaces, B. Biointerfaces,2011(2):270-279. |
| [21] | Zhang J;Wang Q;Wang A .In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug-controlled release matrices.[J].Acta biomaterialia,2010(2):445-454. |
| [22] | Wang, Qin;Xie, Xiaoling;Zhang, Xiaowei;Zhang, Junping;Wang, Aiqin .Preparation and swelling properties of pH-sensitive composite hydrogel beads based on chitosan-g-poly (acrylic acid)/vermiculite and sodium alginate for diclofenac controlled release[J].International Journal of Biological Macromolecules: Structure, Function and Interactions,2010(3):356-362. |
| [23] | Bolong Yao;Caihua Ni;Cheng Xiong;Changping Zhu;Bo Huang .Hydrophobic modification of sodium alginate and its application in drug controlled release[J].Bioprocess and biosystems engineering,2010(4):457-463. |
| [24] | 马福文,靳勇,张文芳,周绍兵,倪才华.星型聚乳酸对海藻酸钠的疏水改性及释药性能研究[J].药学学报,2010(11):1447-1451. |
| [25] | Li Q;Liu C G;Huang Z H et al.Preparation and characterization of nanoparticles based on hydrophobic alginate derivative as carriers for sustained release of vitamin D[J].Journal of Agricultural and Food Chemistry,2011,59(05):1962. |
| [26] | 熊诚 .海藻酸钠的疏水改性及其在药物控释中的应用[D].江南大学,2008. |
| [27] | 王宏丽,张利,左奕,邹琴,周松,李玉宝.海藻酸钠的疏水改性及其对药物的缓释[J].功能材料,2010(09):1568-1570,1574. |
| [28] | Nuran Isiklan;Murat Inal;Fatma Kursun .pH responsive itaconic acid grafted alginate microspheres for the controlled release of nifedipine[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(3):933-943. |
| [29] | Lin, H.-R.;Ou, L.-H.;Lin, Y.-J.;Ling, M.-H. .Hollow, pH-sensitive calcium-alginate/poly(acrylic acid) hydrogel beads as drug carriers for vancomycin release[J].Journal of Applied Polymer Science,2010(4):1878-1886. |
| [30] | 陆遥遥,吴季怀,林建明,黄妙良,李兆乾,冷晴.反应条件对海藻酸钠/聚N-异丙基丙烯酰胺水凝胶温度及pH敏感性能的影响研究[J].材料导报,2010(10):99-104. |
| [31] | Davidovich Pinhas M;Bianco Peled H .Physical and structural characteristics of acrylated poly(ethylene glycol)-alginate conjugates.[J].Acta biomaterialia,2011(7):2817-2825. |
| [32] | 祝侣,朱平,江冬雨,张传杰.丙烯酰胺接枝海藻酸纤维的耐碱性研究[J].合成纤维工业,2010(03):29-32. |
| [33] | Sanchita Mandal;Sanat Kumar Basu;Biswanath Sa .Ca~(2+) ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2010(3):867-873. |
| [34] | Chou A I;Nicoll S B .Characterization of photocrosslinked alginate hydrogels for nucleus pulposus cell encapsulation[J].Journal of Biomedical Materials Research Part A,2009,91A(01):187. |
| [35] | Ho YC;Mi FL;Sung HW .Heparin-functionalized chitosan-alginate scaffolds for controlled release of growth factor.[J].International Journal of Pharmaceutics,2009(1/2):69-75. |
| [36] | Davidovich Pinhas M;Bianco Peled H .Alginate-PEGAc: a new mucoadhesive polymer.[J].Acta biomaterialia,2011(2):625-633. |
| [37] | 孙淑萍,李高,沈灵佳,刘红,周利娟.萘普生海藻酸钙凝胶微丸的制备及体外释药[J].中国医院药学杂志,2007(04):485-487. |
| [38] | 高健.交联海藻酸钠微囊的制备及其在药物缓释中的应用[J].连云港师范高等专科学校学报,2010(02):93-95. |
| [39] | Chan AW;Neufeld RJ .Tuneable semi-synthetic network alginate for absorptive encapsulation and controlled release of protein therapeutics.[J].Biomaterials,2010(34):9040-9047. |
| [40] | Lu, LB;Zhang, P;Cao, Y;Lin, Q;Pang, SJ;Wang, HM .Study on Partially Oxidized Sodium Alginate with Potassium Permanganate as the Oxidant[J].Journal of Applied Polymer Science,2009(6):3585-3589. |
| [41] | Laura Pescosolido;Teresa Piro;Tina Vermonden .Biodegradable IPNs based on oxidized alginate and dextran-HEMA for controlled release of proteins[J].Carbohydrate Polymers: Scientific and Technological Aspects of Industrially Important Polysaccharides,2011(1):208-213. |
| [42] | Gao C;Liu M;Chen S;Jin S;Chen J .Preparation of oxidized sodium alginate-graft-poly((2-dimethylamino) ethyl methacrylate) gel beads and in vitro controlled release behavior of BSA.[J].International Journal of Pharmaceutics,2009(1/2):16-24. |
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