聚磷酸钙(Calcium polyphosphate,CPP)具有优异的生物相容性、生物活性、良好的骨传导性和可生物降解性,其钙磷比为0.5,是具有聚合重复单元的陶瓷基新型无机聚合生物材料,与骨组织有相似的化学成分.另外CPP降解后所释放的钙离子和磷酸根离子参与体内钙磷代谢,被重新沉积到骨组织中,可以加速骨组织矿化促进形成新骨,所以CPP作为一种新型的骨组织替代生物材料已成为研究的热点.详细介绍了CPP及其复合材料的制备、力学性能及生物学性能,对CPP的进一步研究和开发将赋予其更广阔的应用前景.
Calcium polyphosphate(CPP) has excellent biocompatibility, bioactivity, good bone conduction and biodegradability,and its calcium and phosphorus ratio is 0. 5, so CPP is a new ceramic inorganic polymer matrix bio-logical material with polymerizing repeated units, which has similar chemical composition with bone tissue. In addi-tion, the calcium and phosphate ions released from the degradation of CPP will participate calcium and phosphorus me-tabolism in the body, be re-deposited into bone tissue, accelerate the mineralization of bone tissue and promote the for-mation of new bone. Thereby CPP as a new type of biological material substituted for bone tissue has become a re-search hotspot. This paper clearly introduced the preparation, mechanical and biological properties of CPP and its composite materials. With further research and development, CPP will be given a wider application.
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