聚乙烯醇(PVA)是一种水溶性高分子聚合物,常用于眼用制剂、口服制剂、注射剂、微胶囊剂、透皮贴剂、缓释微球及纳米粒等药物载体材料的制备.介绍了水溶性聚乙烯醇材料的特性及型号,以及永溶性PVA作为药物载体材料在制剂及其它药学方面的应用,展望了PVA材料在药物载体材料方面的应用,指出了今后的发展方向和趋势.
参考文献
| [1] | 杨亚楠,尹静波,刘芳.高分子材料在药物控制释放方面的应用[J].吉林工学院学报(自然科学版),2001(03):38-40. |
| [2] | 郑玉炎;汪如明 .白芨胶的制备及临床应用研究[J].福建中医药,1992,23(03):50. |
| [3] | 周建标;蒋子月;郑学洪 .托吡卡胺纸柄眼药膜的制备[J].药学实践杂志,1997,15(01):14. |
| [4] | 宋沧桑,刘小丰,任晓明,王虹.氟康唑眼药膜的研制及体外释放特性[J].中国新药杂志,2003(01):42-44. |
| [5] | Smith T J;Pearson P A;Blandford D L et al.Intravitreal sustained-release ganciclovir[J].Archives of Ophthalmology,1992,110(02):255. |
| [6] | 何文,何平平,张倩.羧甲基壳聚糖/聚乙烯醇甲硝唑水凝胶片在Beagle犬体内的药动学[J].中国医院药学杂志,2008(16):1341-1344. |
| [7] | 张庆云,宋月英,刘璐,朱辉.胸腺五肽-聚乳酸-羟基乙酸微球的制备及释药性能[J].中国组织工程研究与临床康复,2009(21):4055-4058. |
| [8] | Cerchiara T;Luppi B;Bigucci F;Orienti I;Zecchi V .Substituted polyvinylalcohol as a drug carrier for beta-carotene.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2003(3):401-405. |
| [9] | 叶劲,熊昌源,杨仁轩,李其兰,白书臣.鱼腥草注射液-聚乙烯醇凝胶缓释抗菌防治骨关节感染的实验研究[J].中医正骨,2005(01):3-6. |
| [10] | Peppas N A;Robert E .Proposed method of intracordal injection and gelation of poly(vinyl alcohol)solution in vocal cords:Polymer considerations[J].Biomaterials,1980,1(03):158. |
| [11] | Yun J;Kim H .Preparation of poly(vinyl alcohol)/poly(acrylic acid)microcapsules and microspheres and their pH-responsive release behavior[J].Journal of Industrial and Engineering Chemistry,2009,10(02):305. |
| [12] | 高虹,陈明,郑津辉.医用脲酶菌的分离与选育[J].天津师范大学学报(自然科学版),2003(03):24-26. |
| [13] | Davaran S;Rashidi MR;Khandaghi R;Hashemi M .Development of a novel prolonged-release nicotine transdermal patch.[J].Pharmacological research: The official journal of The Italian Pharmacological Society,2005(3):233-237. |
| [14] | Orienti I;Pietra A D;Luppi B et al.Crosslinked polyvinylalcohol hydrogels as vehicles for hydrophilic drugs[M].Department Pharm Sci,2000,19(02):421. |
| [15] | 鲍玉琳,张书平,刘文启,苗云海,费洪柱,丁继芬.口腔药膜的研制与应用[J].医学信息,2002(04):234. |
| [16] | 方宏清 .多肽类药物制剂研究进展[J].药学进展,1998,21(01):16. |
| [17] | 李药兰,黄才欢,岑颖洲,许少玉,徐石海.茶多酚缓释微囊的制备研究[J].中药材,2000(05):281-284. |
| [18] | Sahoo SK.;Panyam J.;Prabha S.;Labhasetwar V. .Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2002(1):105-114. |
| [19] | Hu FQ;Hong Y;Yuan H .Preparation and characterization of solid lipid nanoparticles containing peptide.[J].International Journal of Pharmaceutics,2004(1/2):29-35. |
| [20] | Ryoichi M;Ritsuko H;Yoshiteru T .Development of oral controlled release preparations,a PVA swelling controlled release system(SCRS)[J].Journal of Controlled Release,2000,63(03):297. |
| [21] | Ryoichi M;Ritsuko H;Yoshiteru T .Development of oral controlled release preparations,a PVA swelling controlled release system(SCRS).Ⅱ.In vitro and in vivo evaluation[J].Journal of Controlled Release,2000,68(01):115. |
| [22] | Oha K S;Sung K H;Young W C et al.Hydrogen-bonded polymer gel and its application as a temperature-sensitive drug delivery system[J].BIOMATERIALS,2004,25:2393. |
| [23] | Sunitha K;Kumar P R;Sridhar S .Synthesis and characterization of PVA/PVP blend membranes for the dehydration of acetone by pervaporation[J].Journal of Polymer Materials,2008,25(02):245. |
| [24] | Heath P;Wanida C;Timothy G et al.Structural and magnetic properties of nanoscale iron oxide particles synthesized in the presence of dextran or polyvinyl alcohol[J].Journal of Magnetism and Magnetic Materials,2001,225(01):41. |
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