在生物相容性微球交联聚乙烯醇（CPVA）微球表面实施甲基丙烯酸（MAA）的接枝聚合,制备了高接枝度（30g/100g）的接枝微球CPVA-g-PMAA。研究了接枝微球CPVA-g-PMAA对肌酐分子的吸附性能,分析了吸附机理。结果表明,在较大的pH范围内,CPVA-g-PMAA的Zeta电位为绝对值较大的负值。在强静电相互作用和氢键相互作用的协同下,CPVA-g-PMAA对肌酐分子表现出很强的吸附能力。随介质pH的增高,吸附容量先增大后减小,pH=8.0时,吸附容量最大（40mg/g）;温度升高,吸附容量减小;CPVA-g-PMAA的接枝度增大,吸附容量升高。
Crosslinked polyvinyl alcohol(CPVA) microspheres are a class of polymer microspheres with biocompatibility.The surface-initiated graft polymerization of methacrylic acid(MAA) was performed,resulting in the grafted microspheres CPVA-g-PMAA with a high grafting degree(30g/100g).In this work,the adsorption behavior of the grafted microspheres CPVA-g-PMAA for creatinine was mainly investigated and the adsorption mechanism was explored.The experimental results show that in a wider pH range,the Zeta potential of the microspheres CPVA-g-PMAA is a negative value with a larger absolute value.By the driving of strong electrostatic interaction as well as by the synergism of hydrogen bond interaction,the grafted microspheres CPVA-g-PMAA display very strong adsorption ability for creatinine molecule.The adsorption capacity of the microspheres CPVA-g-PMAA for creatinine first increases and turns in decline with the increase of pH,and there is a maximum adsorption capacity of 40mg/g as pH=8.0.The adsorption capacity of the microspheres CPVA-g-PMAA for creatinine decreases with the increase of the temperature.The greater the grafting degree of the microspheres CPVA-g-PMAA is,the higher the adsorption capacity for creatinine is.
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