探究模拟微重力条件下不同剂量C离子辐射对雄性动物生殖器官的急性影响,以期了解空间环境辐射所致机体生殖系统的损伤。采用小鼠尾部悬吊模型地面模拟微重力状态1周后,利用重离子加速器提供的C离子辐照处理,检测了生殖器官脏器系数及精子密度、组织形态变化、DNA损伤以及细胞凋亡各项指标。结果表明,微重力和C离子辐射均能引起睾丸损伤,且1 Gy单纯辐照组中损伤最为严重。此外发现,模拟微重力能够在一定程度上降低辐射诱导的损伤,其内在机制有待于进一步的研究。
In this paper it was investigated that the effect of modeled microgravity on the acute injury induced by low doses of carbon ions in the male reproductive organs of mice,assessing the risk associated with the space environments.In our study,outbred Kunming mice were stimulated in microgravity by tail suspension,and then were irradiated with the low doses of carbon ions diliuered by HIRFL,and measured the testis and epididymis coefficient,sperm number of epididymis,histological alterations,DNA strand breaks and cell apoptosis.The results demonstrated that carbon ions and stimulated microgravity could induce the damage in the present study.Moreover,most serious injury all occurred in the irradiation group.In addition,it was also found that the damage of the carbon ion irradiation combined microgravity group were lower than those of the irradiation group,while the related mechanism needs the further investigation.
参考文献
| [1] | 戢玉环,李呼伦,王丹丹,等.航天医学与医学工程,2007,20(5):327. |
| [2] | Sharma G S, Sarkar S, Periyakaruppan A, et al. Mol Cell Biochem, 2008, 313(1-2): 71. |
| [3] | 李文建,党秉荣,王转子,等.原子核物理评论,20lO,27(2):206. |
| [4] | Pathak P, Dey S K, Sarma A, et al. Mutation Research, 2007, 632: 58. |
| [5] | Liu Yang, Long Jing, Zhang Luwei, et al. Advances in Space Research, 2010, in press. |
| [6] | 龙静,张红,刘阳,等.核技术,2008,31(6):445. |
| [7] | Sandler H. NASA-TM-88314, 1988, 1-100. |
| [8] | 陈杰,马进,丁兆平,等.空间科学学报,1993,13(2):159. |
| [9] | Hartmann A, Schumacher M, Plappert-Helbig U, et al. Mutagenesis, 2004, 19 51. |
| [10] | Sharma C S, Sarkar S, Periyakaruppan A, et al. Mol Cell Biochem, 2008, 313 71. |
| [11] | Zhang H, Zheng R L, Wang R Y, etal. Mutation Research, 1998, 398 27. |
| [12] | 周艺,朱宝安,郭爱娟,等.航天医学与医学工程,2008,21(6):461. |
| [13] | Tou J, Ronca A, Grindelan K, et al. Biology of Reproduction, 2002, 67: 1681. |
| [14] | Zhang H, Xie Y, Zhou Q M, et al. Advances in Space Research, 2006, 38: 1148. |
| [15] | 赵卫平,张红,王燕玲,等.辐射研究与辐射工艺学报,2008,26(6):343. |
| [16] | Canova S, Fiorasi F, Mognato M, et al. Radiat Res, 2005, 163(2) 191. |
| [17] | 马晓环,魏力军,郑红霞,等.现代生物医学进展,2008,8(12):2204. |
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